Clinicopathologic Features of Secretory Carcinoma of Salivary Gland: An Updated Review
We present a case of secretory carcinoma that was reclassified from cystadenocarcinoma using immunohistochemical and molecular testing and present an updated review of the clinicopathologic features with discussion of differential diagnosis. (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - December 29, 2017 Category: Pathology Tags: Case Reviews Source Type: research
A Protein Lost, a Diagnosis Gained: A Review of SMARCB1-Deficient Sinonasal Carcinomas
In recent years, improved molecular techniques have allowed for extensive reclassification of sinonasal tumors, particularly those previously diagnosed as sinonasal undifferentiated carcinomas. SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily B, member 1-deficient sinonasal carcinoma is one such recently described entity defined by loss of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily B, member 1 (INI1) protein expression by immunohistochemistry. This review characterizes the clinical, histologic, molecular, and immunohistochemical features of thi...
Source: Pathology Case Reviews - December 29, 2017 Category: Pathology Tags: Review Source Type: research
Molecular Testing Uncovers an Adamantinoma-Like Ewing Family of Tumors in the Thyroid: Case Report and Review of Literature
We present a case of a malignant neoplasm of the thyroid showing epithelioid and basaloid nests with metastases to cervical lymph nodes and pancreas. This case was initially classified as a poorly differentiated thyroid carcinoma. Following an extended molecular analysis of the tumor, reverse transcriptase–polymerase chain reaction detected the hallmark EWSR:FLI1 gene fusion. This case was subsequently reclassified as adamantinoma-like EFT. In cases of basaloid or undifferentiated epithelioid tumors, the possibility of adamantinoma-like EFT should be included in a working differential diagnosis. Testing for CD99 and EWSR...
Source: Pathology Case Reviews - December 29, 2017 Category: Pathology Tags: Case Reviews Source Type: research
Noninvasive Follicular Neoplasm of Thyroid With Papillary Like Nuclear Features: A Redefined Indolent Neoplasm of the Thyroid Gland
Follicular variant of papillary thyroid carcinoma (FVPC) represents approximately 30% of all papillary thyroid carcinomas and includes encapsulated, both invasive and noninvasive forms (E-FVPC), and infiltrative FVPCs with different biological behaviors and molecular profiles. The E-FVPC exhibits very low regional recurrence and metastatic potential with a biological behavior similar to that of follicular adenomas.
In 2015, a panel of endocrine pathologists, endocrinologists, surgeons, and patient advocates recommended the revision of the diagnostic terminology for cases of noninvasive E-FVPC to rename them as “noninvas...
Source: Pathology Case Reviews - December 29, 2017 Category: Pathology Tags: Case Reviews Source Type: research
New Names for Old Entities—A Potpouri of Newly Defined Tumors
No abstract available (Source: Pathology Case Reviews)
Source: Pathology Case Reviews - December 29, 2017 Category: Pathology Tags: Editorial Source Type: research
