Intra-Ampullary Papillary-Tubular Neoplasm: An Update on the Ampullary Counterparts of Pancreatobiliary Intraductal Neoplasms

Intra-ampullary papillary tubular neoplasms (IAPNs) are papillary or polypoid lesions that originate from and grow predominantly within the ampulla. They are fundamentally “adenoma-carcinoma sequence” and as such represent intra-ampullary counterparts of other tumoral intraepithelial neoplasms of the pancreatobiliary tract, namely, intraductal papillary mucinous neoplasms (of pancreas), intraductal papillary neoplasms (of bile ducts), intraductal tubulopapillary neoplasms (ITPNs) (of bile ducts and pancreas), and intracholecystic papillary tubular neoplasms (of gallbladder). Intra-ampullary papillary tubular neoplasm–associated invasive carcinoma is now recognized as a distinct subset among ampullary cancers in the College of American Pathologists synoptic reporting. Intra-ampullary papillary tubular neoplasms show a spectrum of neoplastic change from low grade to high grade. Most cases, however, are associated with high-grade dysplasia, and a significant proportion (~75%), also with invasive carcinoma (usually small, often
Source: Pathology Case Reviews - Category: Pathology Tags: Case Reviews Source Type: research