A Protein Lost, a Diagnosis Gained: A Review of SMARCB1-Deficient Sinonasal Carcinomas

In recent years, improved molecular techniques have allowed for extensive reclassification of sinonasal tumors, particularly those previously diagnosed as sinonasal undifferentiated carcinomas. SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily B, member 1-deficient sinonasal carcinoma is one such recently described entity defined by loss of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily B, member 1 (INI1) protein expression by immunohistochemistry. This review characterizes the clinical, histologic, molecular, and immunohistochemical features of this novel entity with an emphasis on its differential diagnosis.
Source: Pathology Case Reviews - Category: Pathology Tags: Review Source Type: research