Immunoexpression of SIRT1, 6, and 7 in oral leukoplakia and oral squamous cell carcinoma
In this study, 82 OLP and 77 OSCC were immunohistochemically examined for SIRT1, 6, and 7. Stained sections were thoroughly scanned and evaluated using a digital image analysis program. The SIRT1, 6, and 7 expressions were detected in the nuclei of epithelial and carcinoma cells in various degrees. Afterward, any correlations among SIRTs, including associations with clinicopathological features and the Kaplan –Meier curves were analyzed. OSCC demonstrated significantly higher SIRT1 expression than OLP, while non-dysplastic lesions showed significantly higher SIRT6 expression than other lesions. A strong correlation was o...
Source: Odontology - May 16, 2023 Category: Dentistry Source Type: research
Push-out bond strength and SEM fractographical analysis of hollow fibre posts used with self-adhesive resin cement: a pilot study
AbstractDetachment is the major cause of failure of endodontic fibre posts. Hollow posts have been recently introduced to overcome such issue. The primary aim of this pilot study was to compare the push-out bond strength of hollow posts and traditional solid posts. Eight round-shaped single-canal premolars extracted for periodontal reason were selected as sample and equally randomized into two groups: (i) traditional solid fibre posts-TECH21xop and ii) hollow fibre posts-TECHOLE. A dual-curing self-adhesive cement (new TECHCEM) was used for posts placement. Six horizontal sections —two from each portion of the root (coro...
Source: Odontology - May 12, 2023 Category: Dentistry Source Type: research
The effect of light compressive and tensile mechanical forces on SOST and POSTN expressions in human periodontal ligament cells: an in vitro study
AbstractPeriodontal ligament (PDL) cells play an important role in mechanosensing and secretion of signaling molecules during bone remodeling. However, the regulatory mechanism is unknown. The aim of the present study is to investigate the expression pattern of periostin and sclerostin in response to orthodontic forces in periodontal ligament cells in vitro. PDL cells were isolated from extracted teeth and treated with compressive forces of 25 Â gr/cm2 or equiaxial tension forces at frequency 1 Â Hz for 0, 24, 48, and 72Â h. qRT-PCR was applied to evaluate the gene expressions. The secretion of sclerostin and periostin was...
Source: Odontology - May 11, 2023 Category: Dentistry Source Type: research
Periodontal diseases in Thai schoolchildren. Clinical and microbiological observations
AbstractThe prevalence of periodontitis among Thai schoolchildren is unknown. In a cross-sectional study, the prevalence and severity of periodontal diseases, in a group of Thai schoolchildren, along with the presence and numbers of bacterial species commonly associated with periodontitis were investigated. A consent form was sent out to 192 schoolchildren in one school (Chanachanupathom School) in Chana, Southern Thailand (in the age range of 12 –18 years) and 119 attended for a clinical and microbiological examination. Clinical recordings included number of teeth present, DMFT, plaque index, bleeding index, clinical a...
Source: Odontology - May 8, 2023 Category: Dentistry Source Type: research
Correction: Physicochemical, mechanical and biological properties of nano-calcium silicate-based cements: a systematic review
(Source: Odontology)
Source: Odontology - May 5, 2023 Category: Dentistry Source Type: research
Fracture behavior of short fiber-reinforced CAD/CAM inlay restorations after cyclic fatigue aging
AbstractThe aim of this study was to assess the fracture behavior of molar teeth restored with MOD inlays made of experimental short fiber-reinforced CAD/CAM composite block (SFRC CAD) before and after cyclic fatigue aging. Standardized MOD cavities were prepared on 60 intact mandibular molars. Three groups of CAD/CAM made inlay restorations (Cerasmart 270, Enamic, and SFRC CAD) were fabricated (n = 20/group). All restorations were luted with self-adhesive dual-cure resin cement (G-Cem One). Half of restored teeth per each group (n = 10) were quasi-statically loaded until fracture without aging. The other half unde...
Source: Odontology - April 25, 2023 Category: Dentistry Source Type: research
Effect of ELVAX polymer subgingival implants with echistatin on extracted and reimplanted rats ’ teeth
AbstractTo investigate the effect of ELVAX polymer subgingival implants incorporated with echistatin peptide on incisor reimplanted tooth in rats. Forty-two male Wistars rats were divided into two groups: echistatin-treated rats (E) and control rats (C). The animals had their right maxillary incisors extracted and treated according to the International Association of Dental Traumatology replantation protocol. The extra-alveolar dry period was 30 and 60 Â min, and the post-surgical experimental periods were 15, 60, and 90Â days. The samples were stained with H&E and analyzed for the presence of an inflammatory response,...
Source: Odontology - April 19, 2023 Category: Dentistry Source Type: research
Clinical, immunological, and microbiological analysis of the association between periodontitis and COVID-19: a case –control study
ConclusionsPeriodontitis was associated with worse COVID-19 outcomes, suggesting the relevance of periodontal care to reduce the burden of overall inflammation. Understanding the crosstalk between SARS-CoV-2 infection and chronic conditions such as periodontitis that can influence disease outcome is important to potentially prevent complications of COVID-19. (Source: Odontology)
Source: Odontology - April 14, 2023 Category: Dentistry Source Type: research
NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome activation via ROS/MAPK/NF- κB signaling in human periodontal ligament cells
AbstractDiabetes mellitus (DM), characterized by production and accumulation of advanced glycation end products (AGEs), induces and promotes chronic inflammation in tissues, including periodontal tissue. Increasing amount of epidemiological and experimental evidence demonstrated that more extensive inflammatory reaction and bone resorption occurred in periodontal tissues in diabetic patients with periodontitis, which is speculated to be related to NLRP3 inflammasome. NLRP10 is the only NOD-like receptor protein lacking leucine-rich repeats, suggesting that NLRP10 may be a regulatory protein. The aim of this study was to in...
Source: Odontology - April 12, 2023 Category: Dentistry Source Type: research
Effect of different surface treatment protocols on the bond strength between lithium disilicate and resin cements
AbstractBecause the use of hydrofluoric acid (HF) poses health risks if handled improperly, many clinicians prefer to have the ceramic restorations pre-etched in dental laboratories. However, during the try-in procedure, the pre-etched glass –ceramic restorations may be contaminated with saliva resulting in reduced bond strength. This in-vitro study aimed to investigate the effect of different surface treatments on the bond strength of lithium disilicate (LD) glass–ceramic restorations (IPS e.max Press, Ivoclar Vivadent) to two resi n cements. One-hundred eighty blocks (4X4X3mm) of LD glass–ceramic were divided into ...
Source: Odontology - April 10, 2023 Category: Dentistry Source Type: research
The effects of different surface treatments applied to milled PMMA denture base material on repair bond strength
This study aims to evaluate the shear bond strength of PMMA repair materials after various surface treatments on CAD/CAM PMMA denture base material. For this purpose, a total of 480 CAD/CAM PMMA denture base test specimens were manufactured. Then all test specimens were divided into 6 groups, and different surface treatments were applied. Group A: sandblasting, Group B: 4% hydro fluoric acid, Group C: tungsten carbide bur, Group D: dichloromethane  + methyl methacrylate mixture, Group E: dichloromethane and methyl methacrylate, Group F: no surface treatment. Each group is then divided into 4 different subcategories; re...
Source: Odontology - April 4, 2023 Category: Dentistry Source Type: research
Curcumin nanoparticles: the topical antimycotic suspension treating oral candidiasis
In conclusion, nanocurcumin has a good antifungal effect as nystatin, however, its therapeutic efficacy takes a longer time to appear than nystatin. The enhanced bioavailability of curcumin at the nanoscale qualifies this nano-herb as a promising alternative therapy for o ral candidiasis, evading nystatin-associated morbidity. (Source: Odontology)
Source: Odontology - March 17, 2023 Category: Dentistry Source Type: research
Adhesive sonic agitation improves bonding durability to class-II cavity preparation
AbstractThe purpose of this study was to evaluate the effect of adhesive sonic agitation on resin –dentin micro-tensile bond strength (µTBS) and interfacial morphology at the gingival wall of class-II cavity preparation. Seventy-two molars with prepared class-II cavities were divided into six groups (n = 12) according to the bonding mode; etch-and-rinse (E&R) or self-etch (SE) and application protocol of the universal adhesive (UA) employed (Clearfil Universal Bond Quick, Kuraray Noritake); following the manufacturer instructions (MI), manual agitation for 20  s (20s), or sonic agitation for 20 s using a modif...
Source: Odontology - March 17, 2023 Category: Dentistry Source Type: research
Compressive strength evaluation of thin occlusal veneers from different CAD/CAM materials, before and after acidic saliva exposure
AbstractIn the present study are depicted valuable observations for practitioners, obtained from an in vitro study which aims to evaluate the compressive strength of occlusal veneers fabricated from 3 type of restorative materials, before and after 1  month of acidic artificial saliva exposure (pH = 2.939). In this context, 90 extracted human molars were prepared to receive computer-aided design/computer-aided manufacturing (CAD/CAM) occlusal veneers. The restorative materials considered in this study were: Cerasmart; Straumann Nice and Tet ric CAD. The occlusal veneers were designed, milled and cemented with an adhes...
Source: Odontology - March 17, 2023 Category: Dentistry Source Type: research
Relationship between age and occlusal force in adults with natural dentition
This study aimed to clarify the relationship between age and occlusal force in adults with natural dentition. A total of 385 adults (180 males and 205 females) with natural dentition participated in this study. Subjects were asked to perform maximum clenching for approximately 3  s, and the occlusal forces on both sides and habitual chewing side were calculated using a dental prescale. Regression analysis was performed by sex with occlusal forces on both sides and habitual chewing side as the dependent variable and age as the independent variable. In addition, all subjects were divided into three groups: young group (20â€...
Source: Odontology - March 17, 2023 Category: Dentistry Source Type: research
