Flaxseed Mucilage (IQP-LU-104) Reduces Body Weight in Overweight and Moderately Obese Individuals in a 12-week, Three-arm, Double-blind, Randomized and Placebo-controlled Clinical Study
Introduction: The aim of this study was to evaluate the benefit and tolerability of two dosages of a proprietary flaxseed mucilage (IQP-LU-104) in reducing body weight in overweight and moderately obese individuals.
Methods: In a double-blind, randomized, placebo-controlled, bi-center trial, 108 participants (Body Mass Index (BMI) 25 to (Source: Obesity Facts)
Source: Obesity Facts - February 7, 2022 Category: Eating Disorders & Weight Management Source Type: research
Lean Mass Loss and Altered Muscular Aerobic Capacity after Bariatric Surgery
Conclusions: Although bariatric surgery has numerous beneficial effects, absolute VO2peak does not improve and the weight loss-induced LM reduction is associated to an altered muscular aerobic capacity, as reflected by an early VT triggering early exercise hyperventilation.Obes Facts (Source: Obesity Facts)
Source: Obesity Facts - January 27, 2022 Category: Eating Disorders & Weight Management Source Type: research
Effect of BMI on the thermogenic response to cold exposure and associated changes in metabolism and browning markers in adult humans
Introduction. Brown adipose tissue (BAT) serves to produce heat by non-shivering thermogenesis. Activation of BAT increases energy expenditure and is seen as a putative strategy to treat obesity. There is conflicting data on the capacity for cold induced thermogenesis in individuals with higher BMI.
Methods. To investigate the effect of BMI on cold-induced stimulation of energy expenditure, changes in the metabolic profile, and the expression of browning markers in subcutaneous white adipose tissue (scWAT), healthy adults (N=173, 50.9 % females) with a median age of 26.0 [Interquartile range (IQR): 23.0;28.0] years and a ...
Source: Obesity Facts - January 26, 2022 Category: Eating Disorders & Weight Management Source Type: research
Impacts of COVID-19 Lockdown on Food Ordering Patterns among Youths in China: The COVID-19 Impact on Lifestyle Change Survey
Conclusion: The participating youths ’ food ordering patterns had significantly changed during the COVID-19 lockdown, with heterogeneities observed to different extents between sexes and across educational levels. Our findings would inform policy makers and health professionals of these changes in time, for better policy making and p ublic health practice.Obes Facts (Source: Obesity Facts)
Source: Obesity Facts - January 26, 2022 Category: Eating Disorders & Weight Management Source Type: research
Erratum
Obes Facts (Source: Obesity Facts)
Source: Obesity Facts - January 25, 2022 Category: Eating Disorders & Weight Management Source Type: research
The effect of an education module to reduce weight bias among medical centers employees: A randomized controlled trial
Conclusions: A single exposure to an online education module on weight bias and knowledge about obesity may confer only a modest short-term improvement in medical center employees fat-phobic attitudes toward people with obes ity. Future studies should examine if re-exposure to such intervention could impact weight bias, stigma, and discrimination among medical center staff in the long-term. (Source: Obesity Facts)
Source: Obesity Facts - January 21, 2022 Category: Eating Disorders & Weight Management Source Type: research
MicroRNAs in Obesity-Associated Disorders: The Role of Exercise Training
Obesity is a worldwide epidemic affecting over 13% of the adult population and is defined by an excess of body fat that predisposes comorbidities. It is considered a multifactorial disease in which environmental and genetic factors interact, and it is a risk marker for cardiovascular disease. Lifestyle modifications remain the mainstay of treatment for obesity based on adequate diet and physical exercise. In addition, obesity is related to cardiovascular and skeletal muscle disorders, such as cardiac hypertrophy, microvascular rarefaction, and skeletal muscle atrophy. The discovery of obesity-involved molecular pathways is...
Source: Obesity Facts - January 20, 2022 Category: Eating Disorders & Weight Management Source Type: research
The Spectrum of Genetic Variants Associated with the Development of Monogenic Obesity in Qatar
Conclusion: These findings highlight the importance of implementing routine testing for genetic variants that predispose for MO in Qatar. Clearly, additional studies of this nature on populations not yet examined are required. At the same time, functional investigations, both in vitro and in vivo, are necessary in order to better understand the role of the variants identified in the pathogenesis of obesity. (Source: Obesity Facts)
Source: Obesity Facts - January 13, 2022 Category: Eating Disorders & Weight Management Source Type: research
The Global Spread of Severe Obesity in Toddlers, Children, and Adolescents: A Systematic Review and Meta-Analysis
Conclusion: Severe pediatric obesity is escalating with a marked increase from the 1980s and a slower rate from 2000. (Source: Obesity Facts)
Source: Obesity Facts - January 11, 2022 Category: Eating Disorders & Weight Management Source Type: research
The Global Spread of Severe Obesity in Toddlers, Children and Adolescents –
a Systematic Review & Meta Analysis
Conclusion: Severe pediatric obesity is escalating with a marked increase from the1980’s and a slower rate from 2000. (Source: Obesity Facts)
Source: Obesity Facts - January 11, 2022 Category: Eating Disorders & Weight Management Source Type: research
Preoperative plasma aldosterone predicts complete remission of type 2 diabetes after bariatric surgery
Conclusion: Preoperative plasma aldosterone levels were related to the CR of type 2 diabetes after BS. Measuring plasma aldosterone levels preoperatively is us eful for predicting the CR of type 2 diabetes after BS. (Source: Obesity Facts)
Source: Obesity Facts - January 11, 2022 Category: Eating Disorders & Weight Management Source Type: research
Issue of Waist Circumference for the Diagnosis of Metabolic Syndrome Regarding Arterial Stiffness: Possible Utility of a Body Shape Index in Middle-Aged Nonobese Japanese Urban Residents Receiving Health Screening
Conclusion: Use of ABSI can detect subjects with arterial stiffening, which may lead to efficient stratification of CVD risk. Further studies are needed to confirm whether MetS diagnosis using ABSI predicts CVD morbidity and mortality.Obes Facts (Source: Obesity Facts)
Source: Obesity Facts - January 10, 2022 Category: Eating Disorders & Weight Management Source Type: research
Weight Change Alters the Small RNA Profile of Urinary Extracellular Vesicles in Obesity
Introduction: Various kidney diseases reportedly show different urinary extracellular vesicles (EVs) RNA profiles. Although obesity is one of the main causes of chronic kidney disease, the expression pattern of urinary EVs RNA in obesity is uncertain. Our aim was to sequence the small RNA profiles of urinary EVs in obese patients before and after weight reduction and compared them to those of healthy volunteers (HVs).
Methods: We recruited age-sex matched obese patients and HVs. The small RNA profiles of urinary EVs were analyzed using RNA sequencing. To evaluate the effect of weight reduction, small RNA profiles of urina...
Source: Obesity Facts - January 10, 2022 Category: Eating Disorders & Weight Management Source Type: research
De-novo and depot-specific androgen production in human adipose tissue - a source of hyperandrogenism in women with obesity
Conclusion: The whole steroidogenic machinery of the classical and backdoor pathways of steroidogenesis, and the capacity for androgen biosynthesis, were found in both AT depots and cultured adipocytes. Therefore, we hypothesize that AT is a de novo site of androgen production and the backdoor pathway of steroidogenesis might be a new pathomechanism for hyperandrogenism in women with obesity. (Source: Obesity Facts)
Source: Obesity Facts - January 4, 2022 Category: Eating Disorders & Weight Management Source Type: research
Effect of obesity and roux-en-y gastric surgery on omeprazole pharmacokinetics
Background: The prevalence of obesity is increasing globally.
Objectives: To evaluate whether gastric bypass surgery modifies the bioavailability and pharmacokinetic (PK) parameters of Omeprazole.
Setting: Hospital Cl ínico San Carlos, Madrid, Spain.
Methods: Controlled, open-label, bioavailability clinical trial in patients undergoing Roux-en-Y gastric bypass (RYGB). Healthy patients with obesity (BMI>35) were included and assessed for Omeprazole PK before RYGB and after (1 and 6 months). PK sampling was done at baseline and several times up to 12 h after drug dosing. Pre- and post-surgery parameters were compared usin...
Source: Obesity Facts - January 3, 2022 Category: Eating Disorders & Weight Management Source Type: research
