De-novo and depot-specific androgen production in human adipose tissue - a source of hyperandrogenism in women with obesity

Conclusion: The whole steroidogenic machinery of the classical and backdoor pathways of steroidogenesis, and the capacity for androgen biosynthesis, were found in both AT depots and cultured adipocytes. Therefore, we hypothesize that AT is a de novo site of androgen production and the backdoor pathway of steroidogenesis might be a new pathomechanism for hyperandrogenism in women with obesity.
Source: Obesity Facts - Category: Eating Disorders & Weight Management Source Type: research