Hormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions
It is now recognized that multivalent interactions of transcriptional proteins can mediate protein recruitment on enhancers. However, the precise regulation of these interactions remains unclear. By studying androgen-responsive enhancers, Chen et al. show that an optimal level of multivalent interactions of androgen receptor is required for enhancer assembly and activation. (Source: Molecular Cell)
Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Lizhen Chen, Zhao Zhang, Qinyu Han, Barun K. Maity, Leticia Rodrigues, Emily Zboril, Rashmi Adhikari, Su-Hyuk Ko, Xin Li, Shawn R. Yoshida, Pengya Xue, Emilie Smith, Kexin Xu, Qianben Wang, Tim Hui-Ming Huang, Shasha Chong, Zhijie Liu Tags: Article Source Type: research
Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping
Zhang et al. combined a proteome-wide screen with machine learning to identify thousands of short linear motifs (degrons) in human proteins that are associated with sequence-dependent protein degradation. They went on to map critical residues, identify interacting ligases, and validate binding for a divers e collection of internal degrons. (Source: Molecular Cell)
Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Zhiqian Zhang, Brandon Sie, Aiquan Chang, Yumei Leng, Christopher Nardone, Richard T. Timms, Stephen J. Elledge Tags: Resource Source Type: research
Regulation of nucleo-cytosolic 26S proteasome translocation by aromatic amino acids via mTOR is essential for cell survival under stress
Livneh et al. show that cellular stress, such as amino acid starvation, leads to translocation of the proteasome from the nucleus to the cytosol, where it stimulates proteolysis. The migration is inhibited by Tyr, Trp, and Phe—newly identified mTOR agonists acting via Sestrin3—leading to cell death. (Source: Molecular Cell)
Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Ido Livneh, Victoria Cohen-Kaplan, Bertrand Fabre, Ifat Abramovitch, Chen Lulu, Nishanth Belugali Nataraj, Ikrame Lazar, Tamar Ziv, Yosef Yarden, Yaniv Zohar, Eyal Gottlieb, Aaron Ciechanover Tags: Article Source Type: research
Implications of a multiscale structure of the yeast nuclear pore complex
Akey et al. report a multiscale structure of the isolated yeast NPC that provides a framework to piece together the roles of nucleoporins in assembly and transport while providing insights into the evolution of critical sub-assemblies. (Source: Molecular Cell)
Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Christopher W. Akey, Ignacia Echeverria, Christna Ouch, Ilona Nudelman, Yi Shi, Junjie Wang, Brian T. Chait, Andrej Sali, Javier Fernandez-Martinez, Michael P. Rout Tags: Article Source Type: research
Alu transposable elements rewire enhancer-promoter network through RNA pairing
A recent study by Liang et al.1 reveals that interacting enhancer RNAs (eRNAs) and promoter-transcribed upstream antisense RNAs (uaRNAs) can identify enhancer-promoter interactions. Complementary sequences within the interacting eRNAs and uaRNAs, predominantly Alu sequences, confer the specificity for eRNA-uaRNA pairing and hence enhancer-promoter recognition. (Source: Molecular Cell)
Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Xingzhao Wen, Sheng Zhong Tags: Spotlight Source Type: research
Fellowship of two rings: Unprecedented insights into the structure of the yeast nuclear pore complex
Akey et al.1 use complementary experimental approaches and AI-based structure prediction to reveal new details of the structure of the yeast nuclear pore complex, providing key insights into evolution, assembly, and nucleocytoplasmic transport mechanisms. (Source: Molecular Cell)
Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Anita H. Corbett, Milo B. Fasken Tags: Preview Source Type: research
Meet the authors: Amy Lee, Shaoni Mukhopadhyay, and Maria Amodeo
We talk to corresponding author Amy Lee and co-authors Shaoni Mukhopadhyay and Maria Amodeo about their scientific journey, research interests, and some behind-the-scenes details of their paper “eIF3d controls the persistent integrated stress response” (this issue of Molecular Cell). (Source: Molecular Cell)
Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Amy Lee, Shaoni Mukhopadhyay, Maria Amodeo Tags: Q & A Source Type: research
Sustainability and molecular biology: An interview with Dr. Andrea Bodnar
Here, Molecular Cell has a discussion with Dr. Andrea Bodnar about GMGI and its various efforts to minimize harm through research and implementing sustainable practices and efforts made at the institutional level to train budding scientists with diverse scientific skills and eco-conscious mindsets. (Source: Molecular Cell)
Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Andrea Bodnar Tags: Q & A Source Type: research
Sustainability and molecular biology: An interview with Dr. Dustin King
Dr. Dustin King spoke with Molecular Cell about his research interests in understanding how bacteria use protein carboxylation to sense greenhouse gases like carbon dioxide, his philosophy towards sustainability, and his hopes for a more sustainable future. (Source: Molecular Cell)
Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Dustin King Tags: Q & A Source Type: research
Sustainability and molecular biology: An interview with Prof. Niels Mailand and Ann Schirin Mirsanaye
Prof. Niels Mailand and Ann Schirin Mirsanaye share with Molecular Cell some of their thoughts on making molecular biology more sustainable, outline their first-hand experiences of having their lab LEAF (Laboratory Efficiency Assessment Framework) certified, and impart some advice to our readers who are considering doing the same. (Source: Molecular Cell)
Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Niels Mailand, Ann Schirin Mirsanaye Tags: Q & A Source Type: research
Sustainability and molecular biology: An interview with Martin Farley
Molecular Cell has a conversation with Martin Farley about LEAF, the program he developed to run molecular biology laboratories in a sustainable way; the obstacles to making molecular biology sustainable; programs available to scientists; and caution to be exercised when taking steps towards sustainability. (Source: Molecular Cell)
Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Martin Farley Tags: Q & A Source Type: research
Sustainability & molecular biology
If you have ever visited the Cell Press Sustainability Hub, you will notice contributions from journals such as One Earth, Cell Reports Sustainability, Trends in Ecology and Evolution, Current Biology, and many others. But you would not have seen any contributions from Molecular Cell. In this issue, we present four Q&As, which we hope will inspire our readers to consider how molecular biology can have both positive and negative impacts on the environment and how subtle shifts in lab practices or new research directions can help. (Source: Molecular Cell)
Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Brian Plosky Tags: Editorial Source Type: research
The cell-cycle choreography of H3 variants shapes the genome
While the canonical core histones comprise typical nucleosomes, histone variants provide unique features linked to a variety of chromatin and DNA transactions. Delaney, Weiss, and Almouzni review the importance of the dynamics of histone H3 variants and how mutations of these variants or perturbations in their dynamics can impact genome integrity and disease. (Source: Molecular Cell)
Source: Molecular Cell - September 20, 2023 Category: Cytology Authors: Kamila Delaney, Nicole Weiss, Genevi ève Almouzni Tags: Review Source Type: research
Completing genome replication outside of S phase
Some loci in the human genome cannot be fully replicated during S phase and complete DNA replication in G2 or early mitosis, a feature that is exacerbated by oncogene activation and other drivers of replication stress. Here, we discuss the strategies used by cells to complete genome duplication outside of S phase. (Source: Molecular Cell)
Source: Molecular Cell - September 15, 2023 Category: Cytology Authors: Rahul Bhowmick, Ian D. Hickson, Ying Liu Tags: Review Source Type: research
Mitochondrial degradation: Mitophagy and beyond
Mitochondria play many important roles in cellular homeostasis, ranging from metabolic regulation to cell signaling. When mitochondria no longer meet cellular needs, they are degraded or removed. In this review, Uoselis et al. cover the many and varied pathways that cells use to rid themselves of unwanted mitochondria. (Source: Molecular Cell)
Source: Molecular Cell - September 13, 2023 Category: Cytology Authors: Louise Uoselis, Thanh Ngoc Nguyen, Michael Lazarou Tags: Review Source Type: research
