Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping

Zhang et  al. combined a proteome-wide screen with machine learning to identify thousands of short linear motifs (degrons) in human proteins that are associated with sequence-dependent protein degradation. They went on to map critical residues, identify interacting ligases, and validate binding for a divers e collection of internal degrons.

Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Zhiqian Zhang, Brandon Sie, Aiquan Chang, Yumei Leng, Christopher Nardone, Richard T. Timms, Stephen J. Elledge Tags: Resource Source Type: research