The Evil DExH/D: Chikungunya virus runs but cannot hide from DDX39A
In this issue, Tapescu et al.11 identify DDX39A as a novel antiviral protein that acts on conserved features of alphavirus RNA to limit infection in an IFN-independent manner. (Source: Molecular Cell)
Source: Molecular Cell - November 16, 2023 Category: Cytology Authors: Matthew G. Thompson, Stacy M. Horner Tags: Preview Source Type: research
Too big not to fail: Different paths lead to senescence of enlarged cells
In this issue of Molecular Cell, Crozier et al.,1 Foy et al.,2 Manohar et al.,3 and Wilson et al.4 show how excessive cell growth caused by a temporary G1 arrest leads to permanent cell cycle exit at different stages of the cell cycle. (Source: Molecular Cell)
Source: Molecular Cell - November 16, 2023 Category: Cytology Authors: Arohi Khurana, Yagya Chadha, Kurt M. Schmoller Tags: Preview Source Type: research
Meet the authors: Achim Keidel and Elena Conti
We talk to authors Achim Keidel and Elena Conti about their paper “Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly” (in this issue of Molecular Cell), staying focused on the scientific question while being open to new approaches and their preferred way to celebrate good news. (Source: Molecular Cell)
Source: Molecular Cell - November 16, 2023 Category: Cytology Authors: Achim Keidel, Elena Conti Tags: Q & A Source Type: research
Stress, epigenetics, and aging: Unraveling the intricate crosstalk
Wu et al. unravel the intricate interplay between stress, aging, and the underlying epigenetics. They highlight a wide array of stresses associated with aging and discuss the multitude of epigenetic modifications involved. They also review intervention strategies that alleviate stress and rejuvenate epi genome, offering comprehensive insights into this burgeoning field. (Source: Molecular Cell)
Source: Molecular Cell - November 13, 2023 Category: Cytology Authors: Zeming Wu, Jing Qu, Weiqi Zhang, Guang-Hui Liu Tags: Review Source Type: research
FMRP phosphorylation modulates neuronal translation through YTHDF1
YTHDF1, a main m6A reader protein, exerts stimulation-induced translation modulation function. Zou et al. show that FMRP binds to YTHDF1 and inhibits its condensation with ribosomal proteins. FMRP serine 499 phosphorylation reverses this effect. YTHDF1 inhibition rebalances the hyperactive translation in FMRP-deficient FXS organoid models and rescues the developmental defects. (Source: Molecular Cell)
Source: Molecular Cell - November 9, 2023 Category: Cytology Authors: Zhongyu Zou, Jiangbo Wei, Yantao Chen, Yunhee Kang, Hailing Shi, Fan Yang, Zhuoyue Shi, Shijie Chen, Ying Zhou, Caraline Sepich-Poore, Xiaoxi Zhuang, Xiaoming Zhou, Hualiang Jiang, Zhexing Wen, Peng Jin, Cheng Luo, Chuan He Tags: Article Source Type: research
RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
This study highlights RNA crosslinking damage as a central component of aldehyde-induced stress. (Source: Molecular Cell)
Source: Molecular Cell - November 9, 2023 Category: Cytology Authors: Shubo Zhao, Jacqueline Cordes, Karolina M. Caban, Maximilian J. G ötz, Timur Mackens-Kiani, Anthony J. Veltri, Niladri K. Sinha, Pedro Weickert, Selay Kaya, Graeme Hewitt, Danny D. Nedialkova, Thomas Fröhlich, Roland Beckmann, Allen R. Buskirk, Rachel G Tags: Article Source Type: research
K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution
Reactive aldehydes are produced by cellular metabolism and accumulate in human tissues if aldehyde clearance mechanisms are impaired. Suryo Rahmanto, Blum et al. demonstrate that formaldehyde induces RNA-protein crosslinks (RPCs) that stall the ribosome and inhibit translation in human cells. The resolution of RPCs is regulated by scarcely studied K6-linked ubiquitylation assembled by an evolutionary conserved E3 ligase. (Source: Molecular Cell)
Source: Molecular Cell - November 9, 2023 Category: Cytology Authors: Aldwin Suryo Rahmanto, Christian J. Blum, Claudia Scalera, Jan B. Heidelberger, Mikhail Mesitov, Daniel Horn-Ghetko, Justus F. Gr äf, Ivan Mikicic, Rebecca Hobrecht, Anna Orekhova, Matthias Ostermaier, Stefanie Ebersberger, Martin M. Möckel, Nils Krapot Tags: Article Source Type: research
The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection
The full spectrum of host RNA-binding proteins that control viral infection remains unclear. Tapescu et al. show that DDX39A binds a conserved RNA structure encoded in the genome of alphaviruses inhibiting infection, independent of the canonical interferon pathway. (Source: Molecular Cell)
Source: Molecular Cell - November 9, 2023 Category: Cytology Authors: Iulia Tapescu, Frances Taschuk, Swechha M. Pokharel, Oleksandr Zginnyk, Max Ferretti, Peter F. Bailer, Kanupryia Whig, Emily A. Madden, Mark T. Heise, David C. Schultz, Sara Cherry Tags: Article Source Type: research
Dormant bacterial spores encrypt a long-lasting transcriptional program to be executed during revival
Zhou et al. show how dormant bacterial spores store the transcriptional instructions required for their anticipated revival. They uncover that throughout the dormant period, core RNA polymerase awaits at a designated chromosomal domain, bound to specific regulatory regions, primed to elicit transcription of the downstream genes upon revival. (Source: Molecular Cell)
Source: Molecular Cell - November 9, 2023 Category: Cytology Authors: Bing Zhou, Yifei Xiong, Yuval Nevo, Tamar Kahan, Oren Yakovian, Sima Alon, Saurabh Bhattacharya, Ilan Rosenshine, Lior Sinai, Sigal Ben-Yehuda Tags: Article Source Type: research
Manipulating the 3D organization of the largest synthetic yeast chromosome
Zhang et al. synthesized a 1.45-Mb extensively modified yeast chromosome from scratch. The gene position/expression relationship was probed by turning synIV inside-out, exchanging the positions of centromeres and telomeres, with little impact on the transcriptome. When tethering synIV to the inner nuclear membrane, transcription throughout synIV was reduced. (Source: Molecular Cell)
Source: Molecular Cell - November 8, 2023 Category: Cytology Authors: Weimin Zhang, Luciana Lazar-Stefanita, Hitoyoshi Yamashita, Michael J. Shen, Leslie A. Mitchell, Hikaru Kurasawa, Evgenii Lobzaev, Viola Fanfani, Max A.B. Haase, Xiaoji Sun, Qingwen Jiang, Gregory W. Goldberg, David M. Ichikawa, Stephanie L. Lauer, Laura Tags: Technology Source Type: research
The proteasome component PSMD14 drives myelomagenesis through a histone deubiquitinase activity
This study highlights PSMD14 as a potential therapeutic target for countering multiple myeloma treatment limitations . (Source: Molecular Cell)
Source: Molecular Cell - November 6, 2023 Category: Cytology Authors: Lin He, Chunyu Yu, Sen Qin, Enrun Zheng, Xinhua Liu, Yanhua Liu, Shimiao Yu, Yang Liu, Xuelin Dou, Zesen Shang, Yizhou Wang, Yue Wang, Xuehong Zhou, Boning Liu, Yuping Zhong, Zhiqiang Liu, Jin Lu, Luyang Sun Tags: Article Source Type: research
Transcriptional elongation control in developmental gene expression, aging, and disease
Transcriptional elongation by RNA polymerase II is a crucial regulatory step in gene expression, and its dysregulation is linked to the mechanisms underlying human disease and aging processes. This review provides a comprehensive overview of both the current mechanistic understanding and the known biological relevance of RNA Pol II elongation factors. (Source: Molecular Cell)
Source: Molecular Cell - November 2, 2023 Category: Cytology Authors: Yuki Aoi, Ali Shilatifard Tags: Review Source Type: research
Protection of Extraribosomal RPL13a by GAPDH and Dysregulation by S-Nitrosylation
(Molecular Cell 47, 656 –663; August 24, 2012) (Source: Molecular Cell)
Source: Molecular Cell - November 2, 2023 Category: Cytology Authors: Jie Jia, Abul Arif, Belinda Willard, Jonathan D. Smith, Dennis J. Stuehr, Stanley L. Hazen, Paul L. Fox Tags: Correction Source Type: research
A Kinase-Independent Function of c-Abl in Promoting Proteolytic Destruction of Damaged DNA Binding Proteins
(Molecular Cell 22, 489 –499; May 19, 2006) (Source: Molecular Cell)
Source: Molecular Cell - November 2, 2023 Category: Cytology Authors: Xiaoai Chen, Jianxuan Zhang, Jennifer Lee, Patrick S. Lin, James M. Ford, Ning Zheng, Pengbo Zhou Tags: Editorial note Source Type: research
Human histone H1 variants impact splicing outcome by controlling RNA polymerase II elongation
Pascal et al. characterized genomic binding profiles of six H1 variants by creating cell lines lacking up to five H1 subtypes. Most H1s bind to specific sites, influenced by factors like GC content. H1 histones regulate mRNA splicing by modulating the elongation rate of RNA polymerase II. (Source: Molecular Cell)
Source: Molecular Cell - November 2, 2023 Category: Cytology Authors: Corina Pascal, Jonathan Zonszain, Ofir Hameiri, Chen Gargi-Levi, Galit Lev-Maor, Luna Tammer, Tamar Levy, Anan Tarabeih, Vanessa Rachel Roy, Stav Ben-Salmon, Liraz Elbaz, Mireille Eid, Tamar Hakim, Salima Abu Rabe'a, Nana Shalev, Albert Jordan, Eran Mesho Tags: Article Source Type: research
