Hormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions

It is now recognized that multivalent interactions of transcriptional proteins can mediate protein recruitment on enhancers. However, the precise regulation of these interactions remains unclear. By studying androgen-responsive enhancers, Chen et  al. show that an optimal level of multivalent interactions of androgen receptor is required for enhancer assembly and activation.

Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Lizhen Chen, Zhao Zhang, Qinyu Han, Barun K. Maity, Leticia Rodrigues, Emily Zboril, Rashmi Adhikari, Su-Hyuk Ko, Xin Li, Shawn R. Yoshida, Pengya Xue, Emilie Smith, Kexin Xu, Qianben Wang, Tim Hui-Ming Huang, Shasha Chong, Zhijie Liu Tags: Article Source Type: research