Completing genome replication outside of S phase

Some loci in the human genome cannot be fully replicated during S phase and complete DNA replication in G2 or early mitosis, a feature that is exacerbated by oncogene activation and other drivers of replication stress. Here, we discuss the strategies used by cells to complete genome duplication outside of S phase.

Source: Molecular Cell - September 15, 2023 Category: Cytology Authors: Rahul Bhowmick, Ian D. Hickson, Ying Liu Tags: Review Source Type: research