Diversity, Equity and Inclusion in the Laboratory: Strategies to Enhance Inclusive Laboratory Culture
Building a diverse laboratory that is equitable is critical for the retention of talent and the growth of trainees professionally and personally. Here, we outline several strategies including enhancing understanding of cultural competency and humility, establishing laboratory values, and developing equitable laboratory structures to create an inclusive laboratory environment to enable trainees to achieve their highest success. (Source: Molecular Cell)
Source: Molecular Cell - November 2, 2023 Category: Cytology Authors: Andrea G. Marshall, Zer Vue, Heather K. Beasley, Kit Neikirk, Dominique Stephens, Celestine N. Wanjalla, Steven M. Damo, JoAnn Trejo, Piere Rodriguez-Aliaga, Colwyn Ansel Headley, Haysetta Shuler, Kaihua Liu, Nathan Smith, Edgar Garza-Lopez, Taylor Barong Tags: Forum Source Type: research
Disordered protein regions partner up the cBAF remodeler for a chromatin dance
Intrinsically disordered protein regions form condensates and mediate interactions with factors that regulate gene activity. Patil et al.1 decode how such regions within the chromatin remodeler cBAF choreograph self-condensation and non-self interactions with transcriptional regulators, potentially impacting disease. (Source: Molecular Cell)
Source: Molecular Cell - November 2, 2023 Category: Cytology Authors: Maren Heimhalt, Andreas G. Ladurner Tags: Spotlight Source Type: research
A tale of two pathways: Two distinct mechanisms of ADAR1 prevent fatal autoinflammation
In this issue, Hu and Heraud-Farlow et al.1 demonstrate that ADAR1 dsRNA editing and dsRNA binding activities are critical to repress MDA5 and PKR, respectively, and that PKR and MDA5 act in concert to induce fatality in ADAR1 KO mice. (Source: Molecular Cell)
Source: Molecular Cell - November 2, 2023 Category: Cytology Authors: Tyler J. Dorrity, Hachung Chung Tags: Preview Source Type: research
A domain of all trades: The enzymatic versatility of the NiRAN domain
The SARS-CoV-2 NiRAN domain is essential for viral replication. Despite adopting a pseudokinase fold, it catalyzes three distinct biochemical reactions from a single active site. In this issue of Molecular Cell, Small et al.1 elucidate the structural intricacies of the NiRAN domain shedding light on the factors that underlie its remarkable versatility. (Source: Molecular Cell)
Source: Molecular Cell - November 2, 2023 Category: Cytology Authors: Adam Osinski, Vincent S. Tagliabracci Tags: Preview Source Type: research
Meet the authors: Yuzhi Wang, Conner Traugot, and Mingyi Xie
We talk to authors Yuzhi Wang, Conner Traugot, and Mingyi Xie about their paper “N6-methyladenosine in 7SK small nuclear RNA underlies RNA polymerase II transcription regulation” (this issue of Molecular Cell), their path to research science, and the interesting findings that keep bringing them back to the bench. (Source: Molecular Cell)
Source: Molecular Cell - November 2, 2023 Category: Cytology Authors: Mingyi Xie, Yuzhi Wang, Conner Traugot Tags: Q & A Source Type: research
Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain
The NiRAN domain in SARS-CoV-2 has been implicated as the enzyme responsible for capping of viral mRNA and NMPylation of nsp9. Small and colleagues reveal the structural basis of mRNA capping and NMPylation of nsp9 and describe how the NiRAN domain catalyzes such distinct activities in the same active site. (Source: Molecular Cell)
Source: Molecular Cell - October 26, 2023 Category: Cytology Authors: Gabriel I. Small, Olga Fedorova, Paul Dominic B. Olinares, Joshua Chandanani, Anoosha Banerjee, Young Joo Choi, Henrik Molina, Brian T. Chait, Seth A. Darst, Elizabeth A. Campbell Tags: Article Source Type: research
Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly
Keidel et al. present a structural view of the interplay between the cytoplasmic RNA exosome and its cofactor, the Ski238 complex, revealing the connection between the helicase activity of Ski2 and the nuclease activity of Rrp44. (Source: Molecular Cell)
Source: Molecular Cell - October 24, 2023 Category: Cytology Authors: Achim Keidel, Alexander K ögel, Peter Reichelt, Eva Kowalinski, Ingmar B. Schäfer, Elena Conti Tags: Article Source Type: research
Lactate activates the mitochondrial electron transport chain independently of its metabolism
Cai et al. found that lactate serves as a mitochondrial messenger that stimulates the electron transport chain independent of its metabolism. Lactate shifts ATP production from glycolysis to oxidative phosphorylation, allowing cells to conserve glucose while using lactate-derived pyruvate as their prefer ential substrate to support cellular ATP production. (Source: Molecular Cell)
Source: Molecular Cell - October 24, 2023 Category: Cytology Authors: Xin Cai, Charles P. Ng, Olivia Jones, Tak Shun Fung, Keun Woo Ryu, Dayi Li, Craig B. Thompson Tags: Article Source Type: research
Maternally inherited siRNAs initiate piRNA cluster formation
Luo et al. elucidate the mechanism behind the genesis of piRNA clusters, highlighting the role of siRNAs originating from repetitive sequences as initiators in this process. This discovery reveals the unanticipated involvement of siRNAs and offers insights into the origin of piRNA clusters. (Source: Molecular Cell)
Source: Molecular Cell - October 23, 2023 Category: Cytology Authors: Yicheng Luo, Peng He, Nivedita Kanrar, Katalin Fejes Toth, Alexei A. Aravin Tags: Article Source Type: research
Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases
Cui et al. identify hyperoxidized PRDX3 as a marker for ferroptosis both in vitro and in vivo. Applying this marker, they demonstrate that hepatic damage in mouse models of AFLD and NAFLD, the most prevalent chronic liver diseases in humans, is caused by ferroptosis. (Source: Molecular Cell)
Source: Molecular Cell - October 19, 2023 Category: Cytology Authors: Shaojie Cui, Anchal Ghai, Yaqin Deng, Shili Li, Ruihui Zhang, Christopher Egbulefu, Guosheng Liang, Samuel Achilefu, Jin Ye Tags: Short article Source Type: research
Detection of alternative DNA structures and its implications for human disease
Matos-Rodrigues et al. present a historical overview and recent advancements in the study of alternative DNA structures. The authors discuss how new technologies have provided insights into causal relationships between the formation of alternative DNA structures, genome instability, and human disease. (Source: Molecular Cell)
Source: Molecular Cell - October 19, 2023 Category: Cytology Authors: Gabriel Matos-Rodrigues, Julia A. Hisey, Andr é Nussenzweig, Sergei M. Mirkin Tags: Technology review Source Type: research
SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops
A recent Nature paper by Xu et al.1 describes an important link between RNA polymerase II promoter-proximal pausing and genome stability orchestrated by liquid droplet formation to reduce unwanted R-loop accumulation. (Source: Molecular Cell)
Source: Molecular Cell - October 19, 2023 Category: Cytology Authors: Natalia Gromak Tags: Spotlight Source Type: research
Fork restart: unloading FANCD2 to travel ahead
In this issue of Molecular Cell, Brunner et al.6 reveal that eliminating FANCD2 from stalled forks via FBXL12-mediated degradation enables cells to tolerate oncogene-induced replication stress, making FBXL12 a promising target for cancer treatment. (Source: Molecular Cell)
Source: Molecular Cell - October 19, 2023 Category: Cytology Authors: Divya R. Iyer, Alan D. D ’Andrea Tags: Preview Source Type: research
ATR takes a crack at the nuclear envelope
In this issue, Joo et al.1 and Kovacs et al.2 report that the ATR kinase promotes nuclear envelope rupture through the phosphorylation of Lamin A/C, inducing processes such as cGAS-STING pathway activation, micronuclei clearance, and potentially cell death. (Source: Molecular Cell)
Source: Molecular Cell - October 19, 2023 Category: Cytology Authors: Marcus B. Smolka, Jan Lammerding Tags: Preview Source Type: research
The crosstalk between DNA repair and immune responses
In recent years, increasing evidence has highlighted the profound connection between DNA damage repair and the activation of immune responses. We spoke with researchers about their mechanistic interplays and the implications for cancer and other diseases. (Source: Molecular Cell)
Source: Molecular Cell - October 19, 2023 Category: Cytology Authors: Karlene A. Cimprich, Guo-Min Li, Sandra Demaria, Nelson O. Gekara, Shan Zha, Qianming Chen Tags: Voices Source Type: research
