Alu transposable elements rewire enhancer-promoter network through RNA pairing

A recent study by Liang et  al.1 reveals that interacting enhancer RNAs (eRNAs) and promoter-transcribed upstream antisense RNAs (uaRNAs) can identify enhancer-promoter interactions. Complementary sequences within the interacting eRNAs and uaRNAs, predominantly Alu sequences, confer the specificity for eRNA-uaRNA pairing and hence enhancer-promoter recognition.

Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Xingzhao Wen, Sheng Zhong Tags: Spotlight Source Type: research