Regulation of nucleo-cytosolic 26S proteasome translocation by aromatic amino acids via mTOR is essential for cell survival under stress

Livneh et  al. show that cellular stress, such as amino acid starvation, leads to translocation of the proteasome from the nucleus to the cytosol, where it stimulates proteolysis. The migration is inhibited by Tyr, Trp, and Phe—newly identified mTOR agonists acting via Sestrin3—leading to cell death.

Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Ido Livneh, Victoria Cohen-Kaplan, Bertrand Fabre, Ifat Abramovitch, Chen Lulu, Nishanth Belugali Nataraj, Ikrame Lazar, Tamar Ziv, Yosef Yarden, Yaniv Zohar, Eyal Gottlieb, Aaron Ciechanover Tags: Article Source Type: research