Curcumin reduces myocardial ischemia-reperfusion injury, by increasing endogenous H < sub > 2 < /sub > S levels and further modulating m < sup > 6 < /sup > A
CONCLUSION: CUR attenuates MIRI by regulating the expression of H2S level-regulating enzymes and increasing the endogenous H2S levels. Increased H2S levels could regulate the m6A-related proteins expression and intracellular total RNA m6A levels.PMID:38643323 | DOI:10.1007/s11033-024-09478-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Jiankun Cui Xin Wang Lingling Dong Qinwen Wang Source Type: research
Decoding the molecular phylogenetics of ornamental catfishes (siluriformes) of North East India using DNA barcoding approach
CONCLUSIONS: In this study, the maximum intraspecific genetic distance of 0.03 and the minimum interspecific genetic distance of 0.14 were observed among the species. Therefore, it is evident that there is a barcoding gap among the species, which helped in the correct identification of the species. Thus, DNA barcoding helped complement the phenetic approach and also revealed a different phylogenetic relationship among the catfishes belonging to the Bagridae family.PMID:38637345 | DOI:10.1007/s11033-024-09487-5 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 18, 2024 Category: Molecular Biology Authors: Grishma S Patil Nevil Pinto Rupak Nath Mukunda Goswami Source Type: research
An SNP based genotyping assay for genes associated with drought tolerance in bread wheat
CONCLUSION: These findings propose that TaSnRK2.9 can be effectively employed for improving wheat through marker-assisted selection in wheat breeding efforts.PMID:38637351 | DOI:10.1007/s11033-024-09481-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 18, 2024 Category: Molecular Biology Authors: Abdul Rauf Muhammad Ali Sher Umar Farooq Awais Rasheed Muhammad Sajjad Ruilian Jing Zulqurnain Khan Kotb A Attia Arif Ahmed Mohammed Sajid Fiaz Jing Chen Shoaib Ur Rehman Source Type: research
Protective effects of arbutin against doxorubicin-induced cardiac damage
CONCLUSION: The study suggests that arbutin has the potential to be used to mitigate doxorubicin-induced cardiotoxicity in cancer patients.PMID:38637360 | DOI:10.1007/s11033-024-09488-4 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 18, 2024 Category: Molecular Biology Authors: Oguzhan Birdal Irmak Ferah Okkay Ufuk Okkay Cemil Bayram Behzad Mokthare Muhammed Sait Ertugrul Ahmet Hacimuftuoglu Emrah Aksakal Yavuzer Koza Mehmet Saygi Huseyin Senocak Source Type: research
The RAS oncogene in brain tumors and the involvement of let-7 microRNA
Mol Biol Rep. 2024 Apr 18;51(1):531. doi: 10.1007/s11033-024-09439-z.ABSTRACTRAS oncogenes are master regulator genes in many cancers. In general, RAS-driven cancers have an oncogenic RAS mutation that promotes disease progression (colon, lung, pancreas). In contrast, brain tumors are not necessarily RAS-driven cancers because RAS mutations are rarely observed. In particular, glioblastomas (the most lethal brain tumor) do not appear to have dominant genetic mutations that are suitable for targeted therapy. Standard treatment for most brain tumors continues to focus on maximal surgical resection, radiotherapy and chemothera...
Source: Molecular Biology Reports - April 18, 2024 Category: Molecular Biology Authors: Samantha Messina Source Type: research
Silymarin and MSC-exosomes ameliorate thioacetamide-evoked renal fibrosis by inhibiting TGF- β/SMAD pathway in rats
CONCLUSION: Using in vitro and in vivo experimental approaches, the research discovered a reno-protective role of silymarin and exosomes of BM-MSCs after thioacetamide-induced renal fibrosis in rats, with the advantage of exosomes.PMID:38637422 | PMC:PMC11026270 | DOI:10.1007/s11033-024-09343-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 18, 2024 Category: Molecular Biology Authors: Dina Mohamed Mekawy Dina Sabry Rania Mohamed Sabry Naglaa F Abozeid Source Type: research
SIRT1 and ZNF350 as novel biomarkers for osteoporosis: a bioinformatics analysis and experimental validation
CONCLUSION: SIRT1 and ZNF350 are important transcriptional regulatory factors for the pathogenesis of OP and may be novel biomarkers for OP treatment.PMID:38637425 | DOI:10.1007/s11033-024-09406-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 18, 2024 Category: Molecular Biology Authors: Naiqiang Zhu Jingyi Hou Jingyuan Si Ning Yang Bin Chen Xu Wei Liguo Zhu Source Type: research
Evodiamine potentiates cisplatin-induced cell death and overcomes cisplatin resistance in non-small-cell lung cancer by targeting SOX9- β-catenin axis
CONCLUSION: The combination of evodiamine and cisplatin may be a novel strategy for combating cisplatin resistance in NSCLC.PMID:38630183 | DOI:10.1007/s11033-024-09477-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Munmun Panda Stuti Biswal Bijesh K Biswal Source Type: research
RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular insights into pathogenesis
CONCLUSIONS: These findings suggest RIPK3 may play a protective role against pterygium recurrence through necroptosis.PMID:38630344 | DOI:10.1007/s11033-024-09368-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Mahnaz Divandari Amin Javadifar Arezoo Baradaran Moghadam Ali Akbar Janatabadi Source Type: research
p-Smad3 differentially regulates the cytological behavior of osteoclasts before and after osteoblasts maturation
CONCLUSIONS: As pre-osteoblasts undergo maturation, p-Smad3 mediated a paracrine effect that transitions osteoclast cellular behaviors from inducing differentiation and stimulating bone formation to promoting apoptosis and coupling angiogenesis.PMID:38632128 | DOI:10.1007/s11033-024-09400-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Jiapeng Ye Zhen Hua Jirimutu Xiao Yang Shao Shaoshuo Li Heng Yin Mao Wu Yi Rong Bowen Hong Yang Guo Yong Ma Jianwei Wang Source Type: research
Gene expression profiling of vitamin D metabolism enzymes in leukemia and lymphoma patients: molecular aspect interplay of VDR, CYP2R1, and CYP24A1
CONCLUSION: The study revealed a noteworthy difference in VDR protein levels between men and women. The highest mean CYP24A1 protein levels were observed in the age group > 60 years. This study found a significant, moderately positive correlation between VDR protein levels and CYP24A1 protein levels in the male and vitamin D sufficiency groups. In addition, a significant positive correlation was found between VDR mRNA levels and CYP2R1 mRNA levels, VDR mRNA levels and CYP2R1 mRNA levels, and CYP2R1 mRNA levels and CYP24A1 mRNA levels. However, the expression of these genes does not correlate with the protein levels of i...
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Anggraini Iriani Andhika Rachman Marsya Kaila Fatina Rizka Kurnia Gemilang Andi Trisnandi Media Fitri Isma Nugraha Source Type: research
Evodiamine potentiates cisplatin-induced cell death and overcomes cisplatin resistance in non-small-cell lung cancer by targeting SOX9- β-catenin axis
CONCLUSION: The combination of evodiamine and cisplatin may be a novel strategy for combating cisplatin resistance in NSCLC.PMID:38630183 | DOI:10.1007/s11033-024-09477-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Munmun Panda Stuti Biswal Bijesh K Biswal Source Type: research
RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular insights into pathogenesis
CONCLUSIONS: These findings suggest RIPK3 may play a protective role against pterygium recurrence through necroptosis.PMID:38630344 | DOI:10.1007/s11033-024-09368-x (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Mahnaz Divandari Amin Javadifar Arezoo Baradaran Moghadam Ali Akbar Janatabadi Source Type: research
p-Smad3 differentially regulates the cytological behavior of osteoclasts before and after osteoblasts maturation
CONCLUSIONS: As pre-osteoblasts undergo maturation, p-Smad3 mediated a paracrine effect that transitions osteoclast cellular behaviors from inducing differentiation and stimulating bone formation to promoting apoptosis and coupling angiogenesis.PMID:38632128 | DOI:10.1007/s11033-024-09400-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Jiapeng Ye Zhen Hua Jirimutu Xiao Yang Shao Shaoshuo Li Heng Yin Mao Wu Yi Rong Bowen Hong Yang Guo Yong Ma Jianwei Wang Source Type: research
Gene expression profiling of vitamin D metabolism enzymes in leukemia and lymphoma patients: molecular aspect interplay of VDR, CYP2R1, and CYP24A1
CONCLUSION: The study revealed a noteworthy difference in VDR protein levels between men and women. The highest mean CYP24A1 protein levels were observed in the age group > 60 years. This study found a significant, moderately positive correlation between VDR protein levels and CYP24A1 protein levels in the male and vitamin D sufficiency groups. In addition, a significant positive correlation was found between VDR mRNA levels and CYP2R1 mRNA levels, VDR mRNA levels and CYP2R1 mRNA levels, and CYP2R1 mRNA levels and CYP24A1 mRNA levels. However, the expression of these genes does not correlate with the protein levels of i...
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Anggraini Iriani Andhika Rachman Marsya Kaila Fatina Rizka Kurnia Gemilang Andi Trisnandi Media Fitri Isma Nugraha Source Type: research
