(+)-Catechin mitigates impairment in insulin secretion and beta cell damage in methylglyoxal-induced pancreatic beta cells
CONCLUSION: This is the first study to examine the impact of a natural compound on methylglyoxal with the insulin-mediated autocrine and paracrine activities of pancreatic beta cells. The results indicate that (+)-Catechin exerts a protective effect against methylglyoxal exposure in pancreatic beta cells and can be considered a potential anti-glycation agent in further investigations on ameliorating diabetic complications.PMID:38520585 | DOI:10.1007/s11033-024-09338-3 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Nair Anaga Krishnan Lekshmy Jayamurthy Purushothaman Source Type: research
Predominance of MGMT promoter methylation among Pakistani glioblastoma patients
CONCLUSION: This is the first comprehensive study highlighting a predominance of MGMT methylation in Pakistani GBM patients. Furthermore, our findings underscore the association of MGMT methylation with improved OS across diverse treatment modalities. Larger studies are imperative to validate our findings for better management of Pakistani GBM patients.PMID:38520591 | DOI:10.1007/s11033-024-09363-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Noor Muhammad Samir Fasih Bilal Malik Shahid Hameed Asif Loya Muhammad Usman Rashid Source Type: research
Conditioned medium of induced pluripotent stem cell derived neuromesodermal progenitors enhances cell migration in vitro
CONCLUSIONS: In vitro data obtained from three distinct cell types suggest a promising role of NMP-CM on cell migration. NMP-CM can be used for wound management in the further future after detailed in vitro and in vivo research.PMID:38520606 | DOI:10.1007/s11033-024-09375-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Ay şegül Doğan Ezgi Bulut Okumu ş Selinay Şenkal Turhan Source Type: research
Development of an allele-specific PCR (AS-PCR) method for identifying high-methyl eugenol-containing purple Tulsi (Ocimum tenuiflorum L.) in market samples
CONCLUSION: The market samples of Tulsi were predominantly derived from purple Tulsi. The AS-PCR method will be helpful for quality control and market surveillance of Tulsi herbal powders.PMID:38520476 | DOI:10.1007/s11033-024-09365-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Raju Balaji Madasamy Parani Source Type: research
Development and characterization of nuclear microsatellite markers for the African walnut Coula edulis Baill (Coulaceae)
CONCLUSIONS: The high polymorphism of the nuclear microsatellite markers developed makes them useful to investigate gene flow and the organization of genetic diversity in C. edulis, and to assess whether particular genetic resources require conservation efforts.PMID:38520482 | DOI:10.1007/s11033-024-09373-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Narcisse Guy Kamdem Saskia Sergeant Camille Vercruysse Vincent Deblauwe Bonaventure Sonk é Olivier J Hardy Source Type: research
Quercetin declines LPS induced inflammation and augments adiponectin expression in 3T3-L1 differentiated adipocytes SIRT-1 dependently
CONCLUSION: This study revealed that QCT treatment reduced crucial pro-inflammatory cytokines levels and increased adiponectin levels following LPS treatment. This finding implies that SIRT-1 may be a crucial factor for the anti-inflammatory activity of QCT.PMID:38520487 | DOI:10.1007/s11033-024-09334-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Zahra Noori Mohammad Sharifi Sanaz Dastghaib Fatemeh Basiri Kejani Fatemeh Roohy Zahra Ansari Mohammad Hasan Maleki Morvarid Siri Sayed Mohammad Shafiee Source Type: research
STAT protein family and cardiovascular diseases: overview of pathological mechanisms and therapeutic implications
Mol Biol Rep. 2024 Mar 23;51(1):440. doi: 10.1007/s11033-024-09371-2.ABSTRACTGlobally, cardiovascular diseases (CVD) are one of the significant causes of death and are considered a major concern of human society. One of the most crucial objectives of scientists is to reveal the mechanisms associated with the pathogenesis of CVD, which has attracted the attention of many scientists. Accumulating evidence showed that the signal transducer and activator of transcription (STAT) signaling pathway is involved in various physiological and pathological processes. According to research on the molecular mechanisms of CVDs, the STAT ...
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Ghader Babaei Samin Sadraei Maral Yarahmadi Samareh Omidvari Aryan Aarabi Masoumeh Rajabibazl Source Type: research
XAF1 overexpression inhibits the malignant progression and cisplatin resistance of NSCLC by activating endoplasmic reticulum stress
CONCLUSION: In conclusion, XAF1 overexpression impeded the advancement of NSCLC and repressed cisplatin resistance of NSCLC cells through inducing ER stress, which indicated that XAF1 might be a novel targeted-therapy for NSCLC.PMID:38520543 | DOI:10.1007/s11033-024-09347-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Bin Chen Yuanjun Cheng Hanqing Wu Jie Yao Source Type: research
Exosomes in renal cell carcinoma: challenges and opportunities
Mol Biol Rep. 2024 Mar 23;51(1):443. doi: 10.1007/s11033-024-09384-x.ABSTRACTRenal cell carcinoma (RCC) is the most common type of kidney cancer that accounts for approximately 2-3% of adult malignancies. Among the primary treatment methods for this type of cancer are surgery and targeted treatment. Still, due to less than optimal effectiveness, there are problems such as advanced distant metastasis, delayed diagnosis, and drug resistance that continue to plague patients. In recent years, therapeutic advances have increased life expectancy and effective treatment in renal cell carcinoma patients. One of these methods is th...
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Mahan Mohammadi Kamran Mansouri Pantea Mohammadi Mehran Pournazari Houshang Najafi Source Type: research
Chemerin promotes invasion of oral squamous cell carcinoma by stimulating IL-6 and TNF- α production via STAT3 activation
CONCLUSION: Our findings indicate that chemerin may play a role in advancing OSCC progression by increasing production of IL-6 and TNF-α, perhaps via a mechanism involving STAT3 signaling.PMID:38520551 | DOI:10.1007/s11033-024-09359-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Zhiyuan Lu Jiayu Liu Quan Wan Yu Wu Wanqiu Wu Yiyang Chen Source Type: research
Evaluation of changes in exhausted T lymphocytes and miRNAs expression in the different trimesters of pregnancy in pregnant women
CONCLUSIONS: Expression pattern of PD-1 and TIM3 in exhausted T lymphocytes is different not only between normal pregnant and RPL women but also in different trimesters of pregnancy. So, our results showed the role of these markers in the modulation lymphocytes activity in different stages of pregnancy.PMID:38520563 | DOI:10.1007/s11033-024-09370-3 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Ali Akbar Shekarchi Leila Hosseini Amin Kamrani Iraj Alipourfard Mohammad Sadegh Soltani-Zangbar Morteza Akbari Leila Roshangar Leili Aghebati-Maleki Forough Chakari-Khiavi Aref Chakari-Khiavi Kimia Motlagh Asghari Shahla Danaii Tannaz Pourlak Javad Ahmad Source Type: research
Synthetic auxin herbicide 2,4-D and its influence on a model BY-2 suspension
This study examined the influence of low 2,4-D concentrations stimulating cell growth in vitro as well as the influence of high herbicide concentrations on the model tobacco BY-2 suspension. The culture took 6 days. Different parameters were evaluated, including the influence of different 2,4-D concentrations on the production of the phytohormone ethylene and its precursor 1-Aminocyclopropane-1-carboxylic acid (ACC) in the tobacco cells. The content of 2,4-D in the cells and the medium was established. The observations of the morphological changes showed that a heavy impregnation of the cell walls taking place depending on...
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Katerina Muselikova Katerina Mouralova Source Type: research
Screening for drought tolerance and genetic diversity of wheat varieties using agronomic and molecular markers
CONCLUSIONS: Taken together, the combination of agronomic and molecular approaches revealed that Karim, Td7, D117 and Utique are the most drought-tolerant wheat varieties. These varieties are particularly promising candidates for genetic improvements and can be utilized as potential genitors for future breeding programs in arid and semi-arid regions.PMID:38520570 | DOI:10.1007/s11033-024-09340-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Asma Guizani Elyes Babay Hend Askri Mariella Finetti Sialer Fatma Gharbi Source Type: research
Role of circular RNA/miRNA axes in the pathophysiology of polycystic ovary syndrome
Mol Biol Rep. 2024 Mar 23;51(1):437. doi: 10.1007/s11033-024-09376-x.ABSTRACTPolycystic ovary syndrome (PCOS) is a disorder resulted from interactions between genetic and environmental factors. Based on the importance of epigenetic factors in the pathoetiology of PCOS, the current review focused on identification of circular RNAs (circRNAs) that are involved in PCOS through acting as molecular sponges for microRNAs (miRNAs). The literature search led to identification of circ_0043533/miR-1179, circ_0030018/miR-136, circ_FURIN/miR-423-5p, circ-FURIN/miR-195-5p, circ_0043532/miR-182, circ_RANBP9/miR-136-5p, circRHBG/miR-515-...
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Mohsen Ahmadi Mohadeseh Fathi Ali Malmir Soudeh Ghafouri-Fard Source Type: research
CTLA-4 expression and polymorphisms in Schizophrenia; a systematic review of literature
This study represents the first systematic review of the literature investigating the impact of CTLA-4 polymorphisms and expression on the development and progression of schizophrenia.Our investigation involved a comprehensive search strategy, using a combination of title, abstract, and MESH terms in four databases, including PubMed, Scopus, Web of Science, and Google Scholar, until August 29th, 2023. The complete texts of the identified records were obtained and rigorously assessed based on predefined exclusion and inclusion criteria. Out of the numerous records, a total of 88 were identified through the databases. 10 stu...
Source: Molecular Biology Reports - March 23, 2024 Category: Molecular Biology Authors: Farzad Fayedeh Sanaz Khorashadizadeh Mohammad Yousefi Sara Abbasifar Nafiseh Erfanian Mitra Rafiee Fahimeh Ghasemi Source Type: research
