An arresten-derived anti-angiogenic peptide triggers apoptotic cell death in endothelial cells
CONCLUSIONS: It might be suggested that Ars induced apoptosis in endothelial cells through the mitochondrial pathway and had no effect on the cell cycle. Besides, Ars induced apoptosis significantly in vivo. However, further studies are required to confirm the detailed molecular mechanism of Ars, this peptide has the potential to be optimized for clinical translations.PMID:38622345 | DOI:10.1007/s11033-024-09448-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Reyhane Chamani Omid Saberi Fatemeh Fathinejad Source Type: research
Hypoxia preconditioning increases Notch1 activity by regulating DNA methylation in vitro and in vivo
CONCLUSION: HPC may confer neuroprotection by activating the Notch1 signaling pathway and regulating its methylation level, resulting in the regeneration of hippocampal neurons.PMID:38622406 | DOI:10.1007/s11033-024-09308-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Zhehan Chang Qi Liu Peijia Fan Wenqiang Xu Yabin Xie Kerui Gong Chunyang Zhang Zhijun Zhao Kai Sun Guo Shao Source Type: research
Phenotypic and genetic characterization of a lipolytic Ralstonia mannitolilytica isolate from petroleum-contaminated soil in Iraq
CONCLUSION: Our findings highlight the potential of Ralstonia mannitolilytica as a promising candidate for lipase production and contribute to our understanding of its genetic diversity and biotechnological applications in hydrocarbon degradation and industrial processes.PMID:38622444 | DOI:10.1007/s11033-024-09468-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Ruaa Saed Abdulkareem Hadeel Kareem Musafer Aqeel Mohammed Majeed Al-Ezee Source Type: research
KASP: a high-throughput genotyping system and its applications in major crop plants for biotic and abiotic stress tolerance
Mol Biol Rep. 2024 Apr 15;51(1):508. doi: 10.1007/s11033-024-09455-z.ABSTRACTAdvances in plant molecular breeding have resulted in the development of new varieties with superior traits, thus improving the crop germplasm. Breeders can screen a large number of accessions without rigorous and time-consuming phenotyping by marker-assisted selection (MAS). Molecular markers are one of the most imperative tools in plant breeding programmes for MAS to develop new cultivars possessing multiple superior traits. Single nucleotide polymorphisms (SNPs) are ideal for MAS due to their low cost, low genotyping error rates, and reproducib...
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Bhawna Dipta Salej Sood Vikas Mangal Vinay Bhardwaj Ajay Kumar Thakur Vinod Kumar Brajesh Singh Source Type: research
The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na < sup > + < /sup > /K < sup > + < /sup > -ATPase
CONCLUSION: These results indicate that the Akt/mTOR/S6K signalling pathway may be involved in the IGF-1 regulating cardiac Na+/K+-ATPase expression and activity.PMID:38622478 | DOI:10.1007/s11033-024-09451-3 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Katarina Banjac Milan Obradovic Sonja Zafirovic Magbubah Essack Zoran Gluvic Milos Sunderic Olgica Nedic Esma R Isenovic Source Type: research
Delving the vitamin D receptor variation and expression profiles in the context of type 2 diabetes among families
CONCLUSION: A linkage was found among the FDRs with probands. Variation in the gene VDR at loci rs731236 and rs2228570 was associated with familial T2D. However further research is required to explore more genetic factors that could influence T2D risks in families.PMID:38622480 | DOI:10.1007/s11033-024-09387-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Asia Parveen Andleeb Batool Abdul Wajid Maryam Mukhtar Khajid Ullah Khan Aqsa Zahid Anjum Jabeen Kashif Iqbal Sahibzada Source Type: research
The evaluation of miR-1181 and miR-4314 as serum microRNA biomarkers for epithelial ovarian cancer diagnosis and prognosis
CONCLUSION: The current study proposed that serum miR-1181 and miR-4314 could discriminate the EOC patients from healthy controls. In addition, both miR-1181 and miR-4314 may be predictive biomarkers for ovarian cancer prognosis. Further studies are needed to confirm the findings of the present study.PMID:38622482 | DOI:10.1007/s11033-024-09464-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Yagmur Minareci Naziye Ak Hamdullah Sozen Ozgur A Tosun Canan Kucukgergin Fatih Aydin İlknur Bingul M Yavuz Salihoglu Samet Topuz Source Type: research
Advancements in understanding bacterial enteritis pathogenesis through organoids
Mol Biol Rep. 2024 Apr 15;51(1):512. doi: 10.1007/s11033-024-09495-5.ABSTRACTBacterial enteritis has a substantial role in contributing to a large portion of the global disease burden and serves as a major cause of newborn mortality. Despite advancements gained from current animal and cell models in improving our understanding of pathogens, their widespread application is hindered by apparent drawbacks. Therefore, more precise models are imperatively required to develop more accurate studies on host-pathogen interactions and drug discovery. Since the emergence of intestinal organoids, massive studies utilizing organoids ha...
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Zhengyang Wu Hongyuan Liu Xianli Wang Source Type: research
A comparative study on the detection of Mycobacterium leprae DNA in urine samples of leprosy patients using Rlep-PCR with other conventional samples
CONCLUSION: The PCR positivity using Rlep gene target (129 bp) was highest in all clinical samples among the study groups, across all types of leprosy. Untreated tuberculoid and PNL leprosy patients showed the highest PCR positivity in urine samples, indicating its potential as a non-invasive diagnostic tool for leprosy and even for contact screening.PMID:38616219 | DOI:10.1007/s11033-024-09470-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 14, 2024 Category: Molecular Biology Authors: Diana David Madhusmita Das Harish Mani Chandra Source Type: research
"Decoding inflammation: glycoprotein a repetition predominant, microRNA-142-3-p, and metastasis associated lung adenocarcinoma transcript 1: as novel inflammatory biomarkers of inflammatory bowel disease"
CONCLUSIONS: Dysregulation of GARP, MALAT1, and miR-142-3p likely contributes to inflammation in IBD by reducing TGF-β. MALAT1 is linked to smoking and age-related changes. These genes have potential as diagnostic markers or therapeutic targets for personalized IBD treatment.PMID:38598005 | DOI:10.1007/s11033-024-09475-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 10, 2024 Category: Molecular Biology Authors: Mohammad Reza Lahimchi Mousa Mohammadnia-Afrouzi Rasoul Baharlou Dariush Haghmorad Seyed Hassan Abedi Delaram Arjmandi Masoomeh Hosseini Bahman Yousefi Source Type: research
Current research on the interaction between Helicobacter pylori and macrophages
Mol Biol Rep. 2024 Apr 10;51(1):497. doi: 10.1007/s11033-024-09395-8.ABSTRACTHelicobacter pylori (H. pylori) is a gram-negative bacteria with a worldwide infection rate of 50%, known to induce gastritis, ulcers and gastric cancer. The interplay between H. pylori and immune cells within the gastric mucosa is pivotal in the pathogenesis of H. pylori-related disease. Following H. pylori infection, there is an observed increase in gastric mucosal macrophages, which are associated with the progression of gastritis. H. pylori elicits macrophage polarization, releases cytokines, reactive oxygen species (ROS) and nitric oxide (NO)...
Source: Molecular Biology Reports - April 10, 2024 Category: Molecular Biology Authors: Yan-Fei Wei Si-An Xie Shu-Tian Zhang Source Type: research
BRAF and RET polymorphism association with thyroid cancer risk, a preliminary study from Khyber Pakhtunkhwa population
CONCLUSION: In conclusion, this study emphasizes the significant association between BRAF polymorphism and thyroid cancer risk, while RET polymorphism showed a less pronounced impact. Further validation using larger and specific datasets is essential to establish conclusive results.PMID:38598020 | DOI:10.1007/s11033-024-09480-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 10, 2024 Category: Molecular Biology Authors: Maryam Batool Najeeb Ullah Khan Hamza Khan Mikhlid H Almutairi Ijaz Ali Brian D Adams Source Type: research
Identification of a novel intronic variant of ATP6V0A2 in a Han-Chinese family with cutis laxa
CONCLUSIONS: In this study, it was identified that ATP6V0A2 gene c. 117 + 5G > T may be the cause of the disease. The non-canonical splicing variants of ATP6V0A2 gene were rarely reported in the past, and this variant expanded the variants spectrum of the gene. The functional study of minigene assay plays a certain role in improving the level of evidence for the pathogenicity of splicing variants, which lays a foundation for prenatal counseling and follow-up gene therapy.PMID:38598037 | DOI:10.1007/s11033-024-09446-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 10, 2024 Category: Molecular Biology Authors: Ying Zhang Mei Sun Na Li Yiran Zhao Fang Zhang Jianbo Shu Yang Liu Chunquan Cai Source Type: research
Silver nanoparticle-induced in vitro flowering in Dendrocalamus strictus (Roxb.) nees and genetic fidelity assessment of regenerants using molecular markers
CONCLUSIONS: It can be inferred that the incorporation of AgNPs during the shoot proliferation phase has the potential to stimulate in vitro flowering in D. strictus. This finding could provide valuable insights into innovative strategies for enhancing crop productivity and genetic manipulation for accelerated breeding and agricultural advancement.PMID:38598057 | DOI:10.1007/s11033-024-09472-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 10, 2024 Category: Molecular Biology Authors: Bharat Singh Rajput M Manokari Nitin J Solanki Dulam Sandhya Mohammad Faisal Abdulrahman A Alatar Mahipal S Shekhawat Source Type: research
Aerobic physical training reduces severe asthma phenotype involving kinins pathway
CONCLUSION: These findings indicate that APT inhibits the severe asthma phenotype by targeting kinin signaling.PMID:38598121 | DOI:10.1007/s11033-024-09474-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 10, 2024 Category: Molecular Biology Authors: Maysa Alves Rodrigues Brandao-Rangel Renilson Moraes-Ferreira Anamei Silva-Reis Victor Hugo Souza-Palmeira Francine Maria Almeida Fabiana Regina da Silva Olimpio Carlos Rocha Oliveira Nilsa Regina Damaceno-Rodrigues Jo ão Bosco Pesquero Leonardo Martin F Source Type: research
