Targeting myocardial inflammation: investigating the therapeutic potential of atrial natriuretic peptide in atrial fibrosis
CONCLUSIONS: The study demonstrates ANP's potential in inhibiting myocardial inflammation and reducing atrial fibrosis. Notably, ANP's effect in countering atrial fibrosis seems to be mediated through the suppression of the Ang II-induced PI3K/Akt-Tenascin-C signaling pathway. These insights enhance our understanding of AF pathogenesis and position ANP as a potential therapeutic agent for treating atrial fibrosis.PMID:38622341 | PMC:PMC11018689 | DOI:10.1007/s11033-024-09393-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Nana Zhu Tianlun Li Yili Bai Jiao Sun Jianping Guo Hongtao Yuan Zhaoliang Shan Source Type: research
An arresten-derived anti-angiogenic peptide triggers apoptotic cell death in endothelial cells
CONCLUSIONS: It might be suggested that Ars induced apoptosis in endothelial cells through the mitochondrial pathway and had no effect on the cell cycle. Besides, Ars induced apoptosis significantly in vivo. However, further studies are required to confirm the detailed molecular mechanism of Ars, this peptide has the potential to be optimized for clinical translations.PMID:38622345 | DOI:10.1007/s11033-024-09448-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Reyhane Chamani Omid Saberi Fatemeh Fathinejad Source Type: research
Hypoxia preconditioning increases Notch1 activity by regulating DNA methylation in vitro and in vivo
CONCLUSION: HPC may confer neuroprotection by activating the Notch1 signaling pathway and regulating its methylation level, resulting in the regeneration of hippocampal neurons.PMID:38622406 | DOI:10.1007/s11033-024-09308-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Zhehan Chang Qi Liu Peijia Fan Wenqiang Xu Yabin Xie Kerui Gong Chunyang Zhang Zhijun Zhao Kai Sun Guo Shao Source Type: research
Phenotypic and genetic characterization of a lipolytic Ralstonia mannitolilytica isolate from petroleum-contaminated soil in Iraq
CONCLUSION: Our findings highlight the potential of Ralstonia mannitolilytica as a promising candidate for lipase production and contribute to our understanding of its genetic diversity and biotechnological applications in hydrocarbon degradation and industrial processes.PMID:38622444 | DOI:10.1007/s11033-024-09468-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Ruaa Saed Abdulkareem Hadeel Kareem Musafer Aqeel Mohammed Majeed Al-Ezee Source Type: research
KASP: a high-throughput genotyping system and its applications in major crop plants for biotic and abiotic stress tolerance
Mol Biol Rep. 2024 Apr 15;51(1):508. doi: 10.1007/s11033-024-09455-z.ABSTRACTAdvances in plant molecular breeding have resulted in the development of new varieties with superior traits, thus improving the crop germplasm. Breeders can screen a large number of accessions without rigorous and time-consuming phenotyping by marker-assisted selection (MAS). Molecular markers are one of the most imperative tools in plant breeding programmes for MAS to develop new cultivars possessing multiple superior traits. Single nucleotide polymorphisms (SNPs) are ideal for MAS due to their low cost, low genotyping error rates, and reproducib...
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Bhawna Dipta Salej Sood Vikas Mangal Vinay Bhardwaj Ajay Kumar Thakur Vinod Kumar Brajesh Singh Source Type: research
The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na < sup > + < /sup > /K < sup > + < /sup > -ATPase
CONCLUSION: These results indicate that the Akt/mTOR/S6K signalling pathway may be involved in the IGF-1 regulating cardiac Na+/K+-ATPase expression and activity.PMID:38622478 | DOI:10.1007/s11033-024-09451-3 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Katarina Banjac Milan Obradovic Sonja Zafirovic Magbubah Essack Zoran Gluvic Milos Sunderic Olgica Nedic Esma R Isenovic Source Type: research
Delving the vitamin D receptor variation and expression profiles in the context of type 2 diabetes among families
CONCLUSION: A linkage was found among the FDRs with probands. Variation in the gene VDR at loci rs731236 and rs2228570 was associated with familial T2D. However further research is required to explore more genetic factors that could influence T2D risks in families.PMID:38622480 | DOI:10.1007/s11033-024-09387-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Asia Parveen Andleeb Batool Abdul Wajid Maryam Mukhtar Khajid Ullah Khan Aqsa Zahid Anjum Jabeen Kashif Iqbal Sahibzada Source Type: research
The evaluation of miR-1181 and miR-4314 as serum microRNA biomarkers for epithelial ovarian cancer diagnosis and prognosis
CONCLUSION: The current study proposed that serum miR-1181 and miR-4314 could discriminate the EOC patients from healthy controls. In addition, both miR-1181 and miR-4314 may be predictive biomarkers for ovarian cancer prognosis. Further studies are needed to confirm the findings of the present study.PMID:38622482 | DOI:10.1007/s11033-024-09464-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Yagmur Minareci Naziye Ak Hamdullah Sozen Ozgur A Tosun Canan Kucukgergin Fatih Aydin İlknur Bingul M Yavuz Salihoglu Samet Topuz Source Type: research
Advancements in understanding bacterial enteritis pathogenesis through organoids
Mol Biol Rep. 2024 Apr 15;51(1):512. doi: 10.1007/s11033-024-09495-5.ABSTRACTBacterial enteritis has a substantial role in contributing to a large portion of the global disease burden and serves as a major cause of newborn mortality. Despite advancements gained from current animal and cell models in improving our understanding of pathogens, their widespread application is hindered by apparent drawbacks. Therefore, more precise models are imperatively required to develop more accurate studies on host-pathogen interactions and drug discovery. Since the emergence of intestinal organoids, massive studies utilizing organoids ha...
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Zhengyang Wu Hongyuan Liu Xianli Wang Source Type: research
Next-generation probiotics: the upcoming biotherapeutics
Mol Biol Rep. 2024 Apr 15;51(1):505. doi: 10.1007/s11033-024-09398-5.ABSTRACTRecent and continuing advances in gut microbiome research have pointed out the role of the gut microbiota as an unexplored source of potentially beneficial probiotic microbes. Along the lines of these advances, both public awareness and acceptance of probiotics are increasing. That's why; academic and industrial research is dedicated to identifying and investigating new microbial strains for the development of next-generation probiotics (NGPs). At this time, there is a growing interest in NGPs as biotherapeutics that alter the gut microbiome and a...
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Omnia Momtaz Al-Fakhrany Engy Elekhnawy Source Type: research
Molecular typing and virulence characteristics of Escherichia coli strains isolated from hospital and community acquired urinary tract infections
CONCLUSION: Our findings indicate the presence of a wide variety of virulence factors in E. coli isolates and the possibility of spreading the same clones in different wards of the hospital.PMID:38622237 | DOI:10.1007/s11033-024-09485-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Zahra Naziri Abdollah Derakhshandeh Maryam Hajirajabi Fatemeh Abbasi Maryam Sadat Moezzi Abolfazl Shirmohamadi Sosfad Source Type: research
Cold atmospheric plasma attenuates skin cancer via ROS induced apoptosis
CONCLUSIONS: These evidences suggest the protective effect of CAP in CSCC, and CAP has the potential clinical application of CSCC.PMID:38622261 | DOI:10.1007/s11033-024-09486-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Changqing Liu Jingjing Zha Tao Sun Ling Kong Xinru Zhang Dong Wang Guohua Ni Source Type: research
Targeting phosphodiesterase 4 as a potential therapy for Parkinson's disease: a review
Mol Biol Rep. 2024 Apr 15;51(1):510. doi: 10.1007/s11033-024-09484-8.ABSTRACTPhosphodiesterases (PDEs) have become a promising therapeutic target for various disorders. PDEs are a vast and diversified family of enzymes that degrade cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which have several biochemical and physiological functions. Phosphodiesterase 4 (PDE4) is the most abundant PDE in the central nervous system (CNS) and is extensively expressed in the mammalian brain, where it catalyzes the hydrolysis of intracellular cAMP. An alteration in the balance of PDE4 and cAMP results in th...
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Pooja Devi Nongthombam Reena Haobam Source Type: research
Resveratrol relieves HFD-induced insulin resistance in skeletal muscle tissue through antioxidant capacity enhancement and the Nrf2-Keap1 signaling pathway
CONCLUSIONS: These results suggest that resveratrol is effective in improving the antioxidant defense system of the skeletal muscle in HFD-fed mice, indicating its therapeutic potential to combat diseases associated with insulin resistance and oxidative stress.PMID:38622329 | DOI:10.1007/s11033-024-09434-4 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Maryam Shabani Hossein Hosseini Mohammad Hassan Tajik Reza Meshkani Asie Sadeghi Source Type: research
Targeting myocardial inflammation: investigating the therapeutic potential of atrial natriuretic peptide in atrial fibrosis
CONCLUSIONS: The study demonstrates ANP's potential in inhibiting myocardial inflammation and reducing atrial fibrosis. Notably, ANP's effect in countering atrial fibrosis seems to be mediated through the suppression of the Ang II-induced PI3K/Akt-Tenascin-C signaling pathway. These insights enhance our understanding of AF pathogenesis and position ANP as a potential therapeutic agent for treating atrial fibrosis.PMID:38622341 | DOI:10.1007/s11033-024-09393-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Nana Zhu Tianlun Li Yili Bai Jiao Sun Jianping Guo Hongtao Yuan Zhaoliang Shan Source Type: research
