p-Smad3 differentially regulates the cytological behavior of osteoclasts before and after osteoblasts maturation

CONCLUSIONS: As pre-osteoblasts undergo maturation, p-Smad3 mediated a paracrine effect that transitions osteoclast cellular behaviors from inducing differentiation and stimulating bone formation to promoting apoptosis and coupling angiogenesis.PMID:38632128 | DOI:10.1007/s11033-024-09400-0

Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Jiapeng Ye Zhen Hua Jirimutu Xiao Yang Shao Shaoshuo Li Heng Yin Mao Wu Yi Rong Bowen Hong Yang Guo Yong Ma Jianwei Wang Source Type: research