Selection of suitable reference genes for normalization of RT-qPCR in three tissues of Northern bobwhite (Colinus virginianus) infected with eyeworm (Oxyspirura petrowi)
CONCLUSION: Based on the geometric mean of all three analyses, our results indicate that the combination of RPL32 and HMBS for the liver, HMBS and SDHA for the spleen, and YWHAZ and HMBS for caecal tonsils might be used as reference genes for normalization in gene expression investigations on Northern bobwhites.PMID:38578540 | DOI:10.1007/s11033-024-09401-z (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Aravindan Kalyanasundaram Brett J Henry Cassandra Henry Jeremiah Leach Ronald J Kendall Source Type: research
The advent of RNA-based therapeutics for metabolic syndrome and associated conditions: a comprehensive review of the literature
Mol Biol Rep. 2024 Apr 5;51(1):493. doi: 10.1007/s11033-024-09457-x.ABSTRACTMetabolic syndrome (MetS) is a prevalent and intricate health condition affecting a significant global population, characterized by a cluster of metabolic and hormonal disorders disrupting lipid and glucose metabolism pathways. Clinical manifestations encompass obesity, dyslipidemia, insulin resistance, and hypertension, contributing to heightened risks of diabetes and cardiovascular diseases. Existing medications often fall short in addressing the syndrome's multifaceted nature, leading to suboptimal treatment outcomes and potential long-term heal...
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Helen Ye Rim Huang Sarah Badar Mohammad Said Siddiqah Shah Hareesha Rishab Bharadwaj Krishna Ramamoorthy Maen Monketh Alrawashdeh Faaraea Haroon Jawad Basit Sajeel Saeed Narjiss Aji Gary Tse Priyanka Roy Mainak Bardhan Source Type: research
Transcriptional patterns of human retinal pigment epithelial cells under protracted high glucose
CONCLUSION: In this study, multiple genes were identified as crucial in the pathological process of RPE under protracted HG, providing potential candidates for future researches on DR. The current study highlights the importance of RPE in DR pathogenesis.PMID:38573426 | DOI:10.1007/s11033-024-09479-5 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 4, 2024 Category: Molecular Biology Authors: Hao Huang Jingshu Zeng Xielan Kuang Fan He Jianjun Yan Bowen Li Wei Liu Huangxuan Shen Source Type: research
Transcriptional patterns of human retinal pigment epithelial cells under protracted high glucose
CONCLUSION: In this study, multiple genes were identified as crucial in the pathological process of RPE under protracted HG, providing potential candidates for future researches on DR. The current study highlights the importance of RPE in DR pathogenesis.PMID:38573426 | DOI:10.1007/s11033-024-09479-5 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 4, 2024 Category: Molecular Biology Authors: Hao Huang Jingshu Zeng Xielan Kuang Fan He Jianjun Yan Bowen Li Wei Liu Huangxuan Shen Source Type: research
Impacts of β-1, 3-N-acetylglucosaminyltransferases (B3GNTs) in human diseases
Mol Biol Rep. 2024 Mar 29;51(1):476. doi: 10.1007/s11033-024-09405-9.ABSTRACTGlycosylation modification of proteins is a common post-translational modification that exists in various organisms and has rich biological functions. It is usually catalyzed by multiple glycosyltransferases located in the Golgi apparatus. β-1,3-N-acetylglucosaminyltransferases (B3GNTs) are members of the glycosyltransferases and have been found to be involved in the occurrence and development of a variety of diseases including autoimmunity diseases, cancers, neurodevelopment, musculoskeletal system, and metabolic diseases. The functions of B3GNT...
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: Anna Xie Jingjing Wang Yi Liu Guoqing Li Nanyang Yang Source Type: research
Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response
CONCLUSION: The simultaneous treatment of resistant colorectal cancer cells with 5-FU and ATR inhibitor, VE-822, was demonstrated to be effective in reversing drug resistance and potentiating 5-FU mediated anticancer effects via targeting DNA damage.PMID:38553623 | DOI:10.1007/s11033-024-09431-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: Ainaz Mihanfar Faezeh Asghari Maryam Majidinia Source Type: research
Cellular and molecular mechanisms of cell damage and cell death in ischemia-reperfusion injury in organ transplantation
Mol Biol Rep. 2024 Mar 29;51(1):473. doi: 10.1007/s11033-024-09261-7.ABSTRACTIschemia-reperfusion injury (IRI) is a critical pathological condition in which cell death plays a major contributory role, and negatively impacts post-transplant outcomes. At the cellular level, hypoxia due to ischemia disturbs cellular metabolism and decreases cellular bioenergetics through dysfunction of mitochondrial electron transport chain, causing a switch from cellular respiration to anaerobic metabolism, and subsequent cascades of events that lead to increased intracellular concentrations of Na+, H+ and Ca2+ and consequently cellular edem...
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: George J Dugbartey Source Type: research
Differential DNA methylation landscape of miRNAs genes in mice liver fibrosis
CONCLUSION: The DNA of 148 miRNA genes was found to have methylation change in liver fibrosis tissue. These discoveries in miRNA genes are beneficial to future miRNA function research in liver fibrosis.PMID:38553662 | DOI:10.1007/s11033-024-09416-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: Deming Li Wentong Yang Jiaojiao Pang Guoying Yu Source Type: research
Impacts of β-1, 3-N-acetylglucosaminyltransferases (B3GNTs) in human diseases
Mol Biol Rep. 2024 Mar 29;51(1):476. doi: 10.1007/s11033-024-09405-9.ABSTRACTGlycosylation modification of proteins is a common post-translational modification that exists in various organisms and has rich biological functions. It is usually catalyzed by multiple glycosyltransferases located in the Golgi apparatus. β-1,3-N-acetylglucosaminyltransferases (B3GNTs) are members of the glycosyltransferases and have been found to be involved in the occurrence and development of a variety of diseases including autoimmunity diseases, cancers, neurodevelopment, musculoskeletal system, and metabolic diseases. The functions of B3GNT...
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: Anna Xie Jingjing Wang Yi Liu Guoqing Li Nanyang Yang Source Type: research
Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response
CONCLUSION: The simultaneous treatment of resistant colorectal cancer cells with 5-FU and ATR inhibitor, VE-822, was demonstrated to be effective in reversing drug resistance and potentiating 5-FU mediated anticancer effects via targeting DNA damage.PMID:38553623 | DOI:10.1007/s11033-024-09431-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: Ainaz Mihanfar Faezeh Asghari Maryam Majidinia Source Type: research
Cellular and molecular mechanisms of cell damage and cell death in ischemia-reperfusion injury in organ transplantation
Mol Biol Rep. 2024 Mar 29;51(1):473. doi: 10.1007/s11033-024-09261-7.ABSTRACTIschemia-reperfusion injury (IRI) is a critical pathological condition in which cell death plays a major contributory role, and negatively impacts post-transplant outcomes. At the cellular level, hypoxia due to ischemia disturbs cellular metabolism and decreases cellular bioenergetics through dysfunction of mitochondrial electron transport chain, causing a switch from cellular respiration to anaerobic metabolism, and subsequent cascades of events that lead to increased intracellular concentrations of Na+, H+ and Ca2+ and consequently cellular edem...
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: George J Dugbartey Source Type: research
Differential DNA methylation landscape of miRNAs genes in mice liver fibrosis
CONCLUSION: The DNA of 148 miRNA genes was found to have methylation change in liver fibrosis tissue. These discoveries in miRNA genes are beneficial to future miRNA function research in liver fibrosis.PMID:38553662 | DOI:10.1007/s11033-024-09416-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: Deming Li Wentong Yang Jiaojiao Pang Guoying Yu Source Type: research
Impacts of β-1, 3-N-acetylglucosaminyltransferases (B3GNTs) in human diseases
Mol Biol Rep. 2024 Mar 29;51(1):476. doi: 10.1007/s11033-024-09405-9.ABSTRACTGlycosylation modification of proteins is a common post-translational modification that exists in various organisms and has rich biological functions. It is usually catalyzed by multiple glycosyltransferases located in the Golgi apparatus. β-1,3-N-acetylglucosaminyltransferases (B3GNTs) are members of the glycosyltransferases and have been found to be involved in the occurrence and development of a variety of diseases including autoimmunity diseases, cancers, neurodevelopment, musculoskeletal system, and metabolic diseases. The functions of B3GNT...
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: Anna Xie Jingjing Wang Yi Liu Guoqing Li Nanyang Yang Source Type: research
Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response
CONCLUSION: The simultaneous treatment of resistant colorectal cancer cells with 5-FU and ATR inhibitor, VE-822, was demonstrated to be effective in reversing drug resistance and potentiating 5-FU mediated anticancer effects via targeting DNA damage.PMID:38553623 | DOI:10.1007/s11033-024-09431-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: Ainaz Mihanfar Faezeh Asghari Maryam Majidinia Source Type: research
Cellular and molecular mechanisms of cell damage and cell death in ischemia-reperfusion injury in organ transplantation
Mol Biol Rep. 2024 Mar 29;51(1):473. doi: 10.1007/s11033-024-09261-7.ABSTRACTIschemia-reperfusion injury (IRI) is a critical pathological condition in which cell death plays a major contributory role, and negatively impacts post-transplant outcomes. At the cellular level, hypoxia due to ischemia disturbs cellular metabolism and decreases cellular bioenergetics through dysfunction of mitochondrial electron transport chain, causing a switch from cellular respiration to anaerobic metabolism, and subsequent cascades of events that lead to increased intracellular concentrations of Na+, H+ and Ca2+ and consequently cellular edem...
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: George J Dugbartey Source Type: research
