The effects of ANRIL polymorphisms on colorectal cancer, tumor stage, and tumor grade among Iranian population
CONCLUSION: The ANRIL rs1333040 polymorphism was associated with a higher risk of CRC and higher TNM stages. ANRIL rs10757274 polymorphism was associated with the well-differentiated tumor in CRC.PMID:38578390 | DOI:10.1007/s11033-024-09420-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Mina Asadi-Tarani Ahmadreza Darashti Mohammadsaeid Javadi Mahnaz Rezaei Mohsen Saravani Saeedeh Salimi Source Type: research
Anti-cancer effects of alpha lipoic acid, cisplatin and paclitaxel combination in the OVCAR-3 ovarian adenocarcinoma cell line
CONCLUSIONS: This study is the first one to investigate the combined treatment of ALA, Cisplatin, Paclitaxel on OVCAR-3. While ALA alone was not effective, combined therapy with ALA, has been found to reduce cell invasion, especially wound healing in the first 24 h, along with tumor cell adhesion.PMID:38578399 | DOI:10.1007/s11033-024-09422-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Hatice Şiyzen Çoban Nazl ı Çil Elif Önder G ülçin Abban Mete Source Type: research
Intertwined relationship of dynamin-related protein 1, mitochondrial metabolism and circadian rhythm
Mol Biol Rep. 2024 Apr 5;51(1):488. doi: 10.1007/s11033-024-09430-8.ABSTRACTIn recent years, mitochondria have gained significant interest in the field of biomedical research due to their impact on human health and ageing. As mitochondrial dynamics are strongly controlled by clock genes, misalignment of the circadian rhythm leads to adverse metabolic health effects. In this review, by exploring various aspects of research and potential links, we hope to update the current understanding of the intricate relationship between DRP1-mediated mitochondrial dynamics and changes in circadian rhythmicity leading to health issues. T...
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Indrani Paramasivan Latha Laxmi Anica Tholath Job Venkatraman Manickam Ramasamy Tamizhselvi Source Type: research
Vitamin D receptor gene BsmI (rs1544410) polymorphism: role in multiple sclerosis and genotype-phenotype correlations
CONCLUSIONS: Our results suggest potential genotype-phenotype correlations for the rs1544410 VDR gene polymorphism in the disease course of MS. Future research on a larger scale is needed to confirm these findings.PMID:38578462 | DOI:10.1007/s11033-024-09369-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Maha Jamoussi Faten Alaya Hela Jamoussi Ghada Baraket Afef Achouri Mariem Ben Mahmoud Saloua Fray Nadia Ben Ali Taieb Messaoud Amel Hannachi Salhi Mohamed Fredj Source Type: research
Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells
CONCLUSIONS: Our findings indicate that N. sativa oil has a dose-dependent effect on cytotoxicity and the expression of apoptotic, heat shock proteins, and matrix metalloproteinases genes in breast and gastric cancer.PMID:38578469 | DOI:10.1007/s11033-024-09453-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: İrfan Çınar Bet ül Gıdık Ebubekir Dirican Source Type: research
Successful application of modified crude DNA extraction from muscle tissues for various types of PCR amplifications
CONCLUSIONS: The developed protocol provides sufficient amount of crude DNA from muscle tissues of different species for PCR amplifications to identify species-of-origin via different techniques coupled with PCR. The simplicity and robustness of this protocol make nucleic acid amplification assays more accessible and affordable to researchers and authorities for both laboratory and point-of-care tests.PMID:38578476 | DOI:10.1007/s11033-024-09356-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Sana Jafar Salman Jamil Muhammad Sheraz Yasin Asif Naseem Muhammad Yasir Zahoor Wasim Shehzad Muhammad Imran Source Type: research
Characterization and expression analysis of GLABRA3 (GL3) genes in cotton: insights into trichome development and hormonal regulation
CONCLUSIONS: In summary, this study lays the foundation for subsequent functional validation of GL3 genes by identifying hormonal regulation patterns and probable sites of action in cotton trichome formation and fiber development. The results stipulate a rationale to elucidate the roles and regulatory mechanisms of GL3 genes in the intricate process of cotton fibre and trichome development.PMID:38578511 | DOI:10.1007/s11033-024-09412-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Naisi Wu Benyi Lu YaSir Muhammad Yaofen Cao Junkang Rong Source Type: research
Harnessing potential of avian eggshell membrane derived collagen hydrolysate for bone tissue regeneration
CONCLUSIONS: The maximum ratio of Col-h/PVA that produced well defined hydrogels was 50:50. Though all the hydrogel matrices alluded towards their competitive attributes and applicability towards restorative bone repair, the hydrogel with 40:60 ratios showed better mechanical strength and cell proliferation than its counterparts. The prominent E. coli growth inhibition by the hydrogel matrices was also observed, along with excellent biocompatibility with MG-63 osteoblasts. The findings indicate strongly the promising application of avian eggshell-derived Col-h in supporting bone regeneration.PMID:38578512 | DOI:10.1007/s11...
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Aakriti Aggarwal Debasish Nath Asish Pal Mahesh Kumar Sah Source Type: research
Association of indoleamine 2,3 dioxygenase, brain derived neurotrophic factor and cellular senescence in type 2 diabetes mellitus with depression: a clinical approach
CONCLUSION: Indoleamine 2,3 dioxygenase, Brain derived neurotrophic factor and cellular senescence may play a role in the progression of the disease. The aforementioned discoveries offer significant contributions to our understanding of the molecular mechanisms that underlie T2DM with depression, potentially aiding in the advancement of prediction and diagnostic methods for this particular ailment.PMID:38578530 | DOI:10.1007/s11033-024-09435-3 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Prasanth Subramanian Venkataraman Prabhu Mohanraj Nehru Rajapriya Palanirasu Rajiv Janardhanan Source Type: research
STING pathway as a cancer immunotherapy: Progress and challenges in activating anti-tumor immunity
Mol Biol Rep. 2024 Apr 5;51(1):487. doi: 10.1007/s11033-024-09418-4.ABSTRACTThe stimulator of the interferon genes (STING) signaling pathway plays a crucial role in innate immunity by detecting cytoplasmic DNA and initiating antiviral host defense mechanisms. The STING cascade is triggered when the enzyme cyclic GMP-AMP synthase (cGAS) binds cytosolic DNA and synthesizes the secondary messenger cGAMP. cGAMP activates the endoplasmic reticulum adaptor STING, leading to the activation of kinases TBK1 and IRF3 that induce interferon production. Secreted interferons establish an antiviral state in infected and adjacent cells. ...
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Mohammad Mahdi Mokhtari Tabar Mahnaz Fathi Fatemeh Kazemi Ghazal Bazregari Abdolmajid Ghasemian Source Type: research
Selection of suitable reference genes for normalization of RT-qPCR in three tissues of Northern bobwhite (Colinus virginianus) infected with eyeworm (Oxyspirura petrowi)
CONCLUSION: Based on the geometric mean of all three analyses, our results indicate that the combination of RPL32 and HMBS for the liver, HMBS and SDHA for the spleen, and YWHAZ and HMBS for caecal tonsils might be used as reference genes for normalization in gene expression investigations on Northern bobwhites.PMID:38578540 | DOI:10.1007/s11033-024-09401-z (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Aravindan Kalyanasundaram Brett J Henry Cassandra Henry Jeremiah Leach Ronald J Kendall Source Type: research
The advent of RNA-based therapeutics for metabolic syndrome and associated conditions: a comprehensive review of the literature
Mol Biol Rep. 2024 Apr 5;51(1):493. doi: 10.1007/s11033-024-09457-x.ABSTRACTMetabolic syndrome (MetS) is a prevalent and intricate health condition affecting a significant global population, characterized by a cluster of metabolic and hormonal disorders disrupting lipid and glucose metabolism pathways. Clinical manifestations encompass obesity, dyslipidemia, insulin resistance, and hypertension, contributing to heightened risks of diabetes and cardiovascular diseases. Existing medications often fall short in addressing the syndrome's multifaceted nature, leading to suboptimal treatment outcomes and potential long-term heal...
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Helen Ye Rim Huang Sarah Badar Mohammad Said Siddiqah Shah Hareesha Rishab Bharadwaj Krishna Ramamoorthy Maen Monketh Alrawashdeh Faaraea Haroon Jawad Basit Sajeel Saeed Narjiss Aji Gary Tse Priyanka Roy Mainak Bardhan Source Type: research
Short-term regulation of TSFM level does not alter amyloidogenesis and mitochondrial function in type-specific cells
CONCLUSIONS: Collectively, short-term regulation of TSFM level in cultured cells does not cause a significant change in proteins involved in APP processing, levels in ROS and ATP associated with mitochondrial function. Whereas our study could contribute to comprehend certain clinical features of TSFM mutations, the roles of TSFM in cardiomyopathy and cancer development might deserve further investigation.PMID:38578353 | DOI:10.1007/s11033-024-09426-4 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Xiao-Yun Li Gui-Feng Zhou Xiong-Yong Xie Ya-Lan Pu Xue -Chen Chen-Lu Li Jie Yang Lu Wang Guo-Jun Chen Source Type: research
Bovine lactoferrin inhibits inflammatory response and apoptosis in lipopolysaccharide-induced acute lung injury by targeting the PPAR- γ pathway
CONCLUSION: This study has suggested that the PPAR-γ pathway is the critical target of bLF in anti-inflammatory reactions and apoptosis of ALI, which provides a direction for further research.PMID:38578368 | DOI:10.1007/s11033-024-09436-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Yantao Li Junhu Li Yan Dong Can Wang Zhigang Cai Source Type: research
Variability in genome size of Trigonella foenum-graecum, Trigonella corniculata and Trigonella caerulea as estimated by flow cytometry indicates complex evolutionary history of fenugreek
CONCLUSIONS: The differences observed in the genome sizes of the three species provide conclusive evidence of their genetic divergence. Additionally, the information about the genome size would provide an impetus to the structural and functional genomics-based research in this crop.PMID:38578370 | DOI:10.1007/s11033-024-09417-5 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Sheel Yadav Ratna Kumari Parimalan Rangan Ambika Baldev Gaikwad Source Type: research
