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A Comprehensive Review on Chemistry and Biology of Tafamidis in Transthyretin Amyloidosis
Mini Rev Med Chem. 2023 Oct 11. doi: 10.2174/0113895575241556231003055323. Online ahead of print.ABSTRACTTransthyretin amyloid cardiomyopathy and Transthyretin amyloid peripheral neuropathy are progressive disease conditions caused by Transthyretin amyloidosis (ATTR) fibril infiltration in the tissue. Transthyretin (TTR) protein misfolding and amyloid fibril deposits are pathological biomarkers of ATTR-related disorders. There are various treatment strategies targeting different stages in pathophysiology. One such strategy is TTR tetramer stabilization. Recently, a new TTR tetramer stabilizer, tafamidis, has been introduce...
Source: Mini Reviews in Medicinal Chemistry - October 13, 2023 Category: Chemistry Authors: Monali B Patil Piyush Ghode Prashant Joshi Source Type: research

Purinergic Signaling and its Role in the Stem Cell Differentiation
Mini Rev Med Chem. 2023 Oct 11. doi: 10.2174/0113895575261206231003151416. Online ahead of print.ABSTRACTPurinergic signaling is a mechanism in which extracellular purines and pyrimidines interact with specialized cell surface receptors known as purinergic receptors. These receptors are divided into two families of P1 and P2 receptors, each responding to different nucleosides and nucleotides. P1 receptors are activated by adenosine, while P2 receptors are activated by pyrimidine and purines. P2X receptors are ligand-gated ion channels, including seven subunits (P2X1-7). However, P2Y receptors are the G-protein coupled rece...
Source: Mini Reviews in Medicinal Chemistry - October 13, 2023 Category: Chemistry Authors: Sumera Zaib None Areeba Imtiaz Khan Source Type: research

Natural and Synthetic Phosphodiesterase Inhibitors in 2023: an Update on the Impact on Neurological and Psychiatric Conditions
Mini Rev Med Chem. 2023 Oct 4. doi: 10.2174/0113895575267412230926055026. Online ahead of print.ABSTRACTThis Perspective provides an updated overview on the involvement of phosphodiesterase (PDE) isoforms and of the corresponding inhibitors in neurological disorders, including dementia, Parkinson's disease, multiple sclerosis, neuropsychiatric conditions and cerebral ischemia. Particular attention has been dedicated to natural and semi-synthetic compounds. Translation into the clinic of preclinical results, toxicity profile and bioavailability represent the challenging aspects in the development of PDE inhibitors. With the...
Source: Mini Reviews in Medicinal Chemistry - October 11, 2023 Category: Chemistry Source Type: research

HDAC9 as a Privileged Target: Reviewing its Role in Different Diseases and Structure-activity Relationships (SARs) of its Inhibitors
Mini Rev Med Chem. 2023 Oct 5. doi: 10.2174/0113895575267301230919165827. Online ahead of print.ABSTRACTHDAC9 is a histone deacetylase enzyme belonging to the class IIa of HDACs which catalyses histone deacetylation. HDAC9 inhibit cell proliferation by repairing DNA, arresting the cell cycle, inducing apoptosis, and altering genetic expression. HDAC9 plays a significant part in human physiological system and are involved in various type of diseases like cancer, diabetes, atherosclerosis and CVD, autoimmune response, inflammatory disease, osteoporosis and liver fibrosis. This review discusses the role of HDAC9 in different ...
Source: Mini Reviews in Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Totan Das Samima Khatun Tarun Jha Shovanlal Gayen Source Type: research

Recent Advances in Nanobiotechnology for the Treatment of Non-Hodgkin's Lymphoma
Mini Rev Med Chem. 2023 Sep 15. doi: 10.2174/1389557523666230915103121. Online ahead of print.ABSTRACTLymphoma is the eighth most common type of cancer worldwide. Currently, lymphoma is mainly classified into two main groups: Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL), with NHL accounting for 80% to 90% of the cases. NHL is primarily divided into B, T, and natural killer (NK) cell lymphoma. Nanotechnology is developing rapidly and has made significant contributions to the field of medicine. This review summarizes the advancements of nanobiotechnology in recent years and its applications in the treatment of NH...
Source: Mini Reviews in Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Shuxian Liu Minghao Xu Lei Zhong Xiangmin Tong Suying Qian Source Type: research