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Ebselen: A Review on its Synthesis, Derivatives, Anticancer Efficacy and Utility in Combating SARS-COV-2
Mini Rev Med Chem. 2023 Sep 14. doi: 10.2174/1389557523666230914103339. Online ahead of print.ABSTRACTEbselen is a selenoorganic chiral compound with antioxidant properties comparable to glutathione peroxidase. It is also known as 2-phenyl-1,2-benzisoselenazol-3(2H)-one. In studies examining its numerous pharmacological activities, including antioxidant, anticancer, antiviral, and anti-Alzheimer's, ebselen has demonstrated promising results. This review's primary objective was to emphasize the numerous synthesis pathways of ebselen and their efficacy in fighting cancer. The data were collected from multiple sources, includ...
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Farak Ali Shahnaz Alom Sheikh Rezzak Ali Biswanarayan Kondoli Prativa Sadhu Chinmoyee Borah Bibhuti Bushan Kakoti Surajit Kumar Ghosh Anshul Shakya Abdul Baquee Ahmed Udaya Pratap Singh Hans Raj Bhatt Source Type: research
The most recent compilation of reactions of enaminone derivatives with various amine derivatives to generate biologically active compounds
Mini Rev Med Chem. 2023 Sep 13. doi: 10.2174/1389557523666230913164038. Online ahead of print.ABSTRACTHeterocyclic derivatives serve as the fundamental components of both natural and synthetic drugs. Enaminones play a crucial role as foundational units in the synthesis of numerous bioactive heterocyclic compounds, including pyrazoles, pyridines, oxazoles, isoxazoles, as well as fused heterocyclic structures like indoles, carbazoles, quinolines, acridines, and phenanthridines. These diverse heterocyclic rings are well-known for their various therapeutic activities, encompassing anticancer, anti-inflammatory, antimicrobial, ...
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Thoraya A Farghaly Amal M Alosaimy Nadia T Al-Qurashi Ghada S Masaret Hanan Gaber Abdulwahab Source Type: research
Drug Delivery System Approaches for Rheumatoid Arthritis Treatment: A Review
In conclusion, nanocarrier-based drug delivery systems have emerged as a promising solution for improving the treatment of rheumatoid arthritis. Further advancements in nanotechnology hold promise for enhancing the efficacy and safety of RA therapies, offering new hope for patients suffering from this debilitating disease.PMID:37711105 | DOI:10.2174/1389557523666230913105803 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Anushka Garhwal Priyadarshi Kendya Sakshi Soni Shivam Kori Vandana Soni Sushil Kumar Kashaw Source Type: research
The Use of Nanocarriers to Enhance the Anti-neuroinflammatory Potential of Dietary Flavonoids in Animal Models of Neurodegenerative Diseases: A Systematic Review
CONCLUSION: Nanoencapsulated flavonoids should, therefore, be considered a novel therapeutic approach for the treatment of NDs.PMID:37691188 | DOI:10.2174/1389557523666230907093441 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Gopalsamy Rajiv Gandhi Varghese Edwin Hillary Kumaraswamy Athesh Maria Let ícia Carvalho da Cruz Ramos Gabriela Peres de Oliveira Krauss Gnanasekaran Jothi Gurunagarajan Sridharan Rengaraju Sivasubramanian Govindasamy Hariharan Alan Bruno Silva Vasconcel Source Type: research
Comprehensive Review on Recent Strategies for Management of Prostate Cancer: Therapeutic Targets and SAR
This article also emphasized the recent advances in the field of medicinal chemistry of prostate cancer agents.PMID:37694781 | DOI:10.2174/1389557523666230911141339 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Manish Chaudhary Shubham Kumar Paranjeet Kaur Sanjeev Kumar Sahu Amit Mittal Source Type: research
Antimicrobial and cytotoxic naphthoquinones from microbial origin: An updated review
Mini Rev Med Chem. 2023 Sep 11. doi: 10.2174/1389557523666230911141331. Online ahead of print.ABSTRACTNaphthoquinones (NQs) are small molecules bearing two carbonyl groups. They have been the subject of much research due to their significant biological activities such as antiproliferative, antimicrobial, anti-inflammatory, antioxidant, and antimalarial effects. NQs are produced mainly by bacteria, fungi and higher plants. Among them, microorganisms are a treasure of NQs with diverse skeletons and pharmacological properties. The purpose of the present study is to provide a comprehensive update on the structural diversity an...
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Marziyeh Esmaeilzadeh Kashi Mahdiyeh Ghanbari Hasan Badibostan Veronique Seidel Seyed Hamzeh Hosseini Javad Asili Abolfazl Shakeri Amirhossein Sahebkar Source Type: research
The Use of Nanocarriers to Enhance the Anti-neuroinflammatory Potential of Dietary Flavonoids in Animal Models of Neurodegenerative Diseases: A Systematic Review
CONCLUSION: Nanoencapsulated flavonoids should, therefore, be considered a novel therapeutic approach for the treatment of NDs.PMID:37691188 | DOI:10.2174/1389557523666230907093441 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Gopalsamy Rajiv Gandhi Varghese Edwin Hillary Kumaraswamy Athesh Maria Let ícia Carvalho da Cruz Ramos Gabriela Peres de Oliveira Krauss Gnanasekaran Jothi Gurunagarajan Sridharan Rengaraju Sivasubramanian Govindasamy Hariharan Alan Bruno Silva Vasconcel Source Type: research
Comprehensive Review on Recent Strategies for Management of Prostate Cancer: Therapeutic Targets and SAR
This article also emphasized the recent advances in the field of medicinal chemistry of prostate cancer agents.PMID:37694781 | DOI:10.2174/1389557523666230911141339 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Manish Chaudhary Shubham Kumar Paranjeet Kaur Sanjeev Kumar Sahu Amit Mittal Source Type: research
Antimicrobial and cytotoxic naphthoquinones from microbial origin: An updated review
Mini Rev Med Chem. 2023 Sep 11. doi: 10.2174/1389557523666230911141331. Online ahead of print.ABSTRACTNaphthoquinones (NQs) are small molecules bearing two carbonyl groups. They have been the subject of much research due to their significant biological activities such as antiproliferative, antimicrobial, anti-inflammatory, antioxidant, and antimalarial effects. NQs are produced mainly by bacteria, fungi and higher plants. Among them, microorganisms are a treasure of NQs with diverse skeletons and pharmacological properties. The purpose of the present study is to provide a comprehensive update on the structural diversity an...
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Marziyeh Esmaeilzadeh Kashi Mahdiyeh Ghanbari Hasan Badibostan Veronique Seidel Seyed Hamzeh Hosseini Javad Asili Abolfazl Shakeri Amirhossein Sahebkar Source Type: research
The Use of Nanocarriers to Enhance the Anti-neuroinflammatory Potential of Dietary Flavonoids in Animal Models of Neurodegenerative Diseases: A Systematic Review
CONCLUSION: Nanoencapsulated flavonoids should, therefore, be considered a novel therapeutic approach for the treatment of NDs.PMID:37691188 | DOI:10.2174/1389557523666230907093441 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Gopalsamy Rajiv Gandhi Varghese Edwin Hillary Kumaraswamy Athesh Maria Let ícia Carvalho da Cruz Ramos Gabriela Peres de Oliveira Krauss Gnanasekaran Jothi Gurunagarajan Sridharan Rengaraju Sivasubramanian Govindasamy Hariharan Alan Bruno Silva Vasconcel Source Type: research
Comprehensive Review on Recent Strategies for Management of Prostate Cancer: Therapeutic Targets and SAR
This article also emphasized the recent advances in the field of medicinal chemistry of prostate cancer agents.PMID:37694781 | DOI:10.2174/1389557523666230911141339 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Manish Chaudhary Shubham Kumar Paranjeet Kaur Sanjeev Kumar Sahu Amit Mittal Source Type: research
Antimicrobial and cytotoxic naphthoquinones from microbial origin: An updated review
Mini Rev Med Chem. 2023 Sep 11. doi: 10.2174/1389557523666230911141331. Online ahead of print.ABSTRACTNaphthoquinones (NQs) are small molecules bearing two carbonyl groups. They have been the subject of much research due to their significant biological activities such as antiproliferative, antimicrobial, anti-inflammatory, antioxidant, and antimalarial effects. NQs are produced mainly by bacteria, fungi and higher plants. Among them, microorganisms are a treasure of NQs with diverse skeletons and pharmacological properties. The purpose of the present study is to provide a comprehensive update on the structural diversity an...
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Marziyeh Esmaeilzadeh Kashi Mahdiyeh Ghanbari Hasan Badibostan Veronique Seidel Seyed Hamzeh Hosseini Javad Asili Abolfazl Shakeri Amirhossein Sahebkar Source Type: research
The Use of Nanocarriers to Enhance the Anti-neuroinflammatory Potential of Dietary Flavonoids in Animal Models of Neurodegenerative Diseases: A Systematic Review
CONCLUSION: Nanoencapsulated flavonoids should, therefore, be considered a novel therapeutic approach for the treatment of NDs.PMID:37691188 | DOI:10.2174/1389557523666230907093441 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Gopalsamy Rajiv Gandhi Varghese Edwin Hillary Kumaraswamy Athesh Maria Let ícia Carvalho da Cruz Ramos Gabriela Peres de Oliveira Krauss Gnanasekaran Jothi Gurunagarajan Sridharan Rengaraju Sivasubramanian Govindasamy Hariharan Alan Bruno Silva Vasconcel Source Type: research
Comprehensive Review on Recent Strategies for Management of Prostate Cancer: Therapeutic Targets and SAR
This article also emphasized the recent advances in the field of medicinal chemistry of prostate cancer agents.PMID:37694781 | DOI:10.2174/1389557523666230911141339 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Manish Chaudhary Shubham Kumar Paranjeet Kaur Sanjeev Kumar Sahu Amit Mittal Source Type: research
Antimicrobial and cytotoxic naphthoquinones from microbial origin: An updated review
Mini Rev Med Chem. 2023 Sep 11. doi: 10.2174/1389557523666230911141331. Online ahead of print.ABSTRACTNaphthoquinones (NQs) are small molecules bearing two carbonyl groups. They have been the subject of much research due to their significant biological activities such as antiproliferative, antimicrobial, anti-inflammatory, antioxidant, and antimalarial effects. NQs are produced mainly by bacteria, fungi and higher plants. Among them, microorganisms are a treasure of NQs with diverse skeletons and pharmacological properties. The purpose of the present study is to provide a comprehensive update on the structural diversity an...
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Marziyeh Esmaeilzadeh Kashi Mahdiyeh Ghanbari Hasan Badibostan Veronique Seidel Seyed Hamzeh Hosseini Javad Asili Abolfazl Shakeri Amirhossein Sahebkar Source Type: research