Mini Reviews in Medicinal Chemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Comprehensive Review on Recent Strategies for Management of Prostate Cancer: Therapeutic Targets and SAR
This article also emphasized the recent advances in the field of medicinal chemistry of prostate cancer agents.PMID:37694781 | DOI:10.2174/1389557523666230911141339 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Manish Chaudhary Shubham Kumar Paranjeet Kaur Sanjeev Kumar Sahu Amit Mittal Source Type: research

Antimicrobial and cytotoxic naphthoquinones from microbial origin: An updated review
Mini Rev Med Chem. 2023 Sep 11. doi: 10.2174/1389557523666230911141331. Online ahead of print.ABSTRACTNaphthoquinones (NQs) are small molecules bearing two carbonyl groups. They have been the subject of much research due to their significant biological activities such as antiproliferative, antimicrobial, anti-inflammatory, antioxidant, and antimalarial effects. NQs are produced mainly by bacteria, fungi and higher plants. Among them, microorganisms are a treasure of NQs with diverse skeletons and pharmacological properties. The purpose of the present study is to provide a comprehensive update on the structural diversity an...
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Marziyeh Esmaeilzadeh Kashi Mahdiyeh Ghanbari Hasan Badibostan Veronique Seidel Seyed Hamzeh Hosseini Javad Asili Abolfazl Shakeri Amirhossein Sahebkar Source Type: research

The application of MD simulation to lead identification, vaccine design, and structural studies in combat against leishmaniasis - A review
Mini Rev Med Chem. 2023 Sep 1. doi: 10.2174/1389557523666230901105231. Online ahead of print.ABSTRACTDrug discovery, vaccine design, and protein interaction studies are rapidly moving toward the routine use of molecular dynamics simulations (MDS) and related methods. As a result of MDS, it is possible to gain insights into the dynamics and function of identified drug targets, antibody-antigen interactions, potential vaccine candidates, intrinsically disordered proteins, and essential proteins. The MDS appears to be used in all possible ways in combating diseases such as cancer, however, it has not been well documented as t...
Source: Mini Reviews in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: Saravanan Vijayakumar Lukkani Laxman Kumar Subhomoi Borkotoky Ayaluru Murali Source Type: research

The Power of Molecular Dynamics Simulations and Their Applications to Discover Cysteine Protease Inhibitors
Mini Rev Med Chem. 2023 Sep 1. doi: 10.2174/1389557523666230901152257. Online ahead of print.ABSTRACTA large family of enzymes with the function of hydrolyzing peptide bonds, called peptidases or cysteine proteases (CPs), are divided into three categories according to the peptide chain involved. CPs catalyze the hydrolysis of amide, ester, thiol ester, and thioester peptide bonds. They can be divided into several groups, such as papain-like (CA), viral chymotrypsin-like CPs (CB), papain-like endopeptidases of RNA viruses (CC), legumain-type caspases (CD), and showing active residues of His, Glu/Asp, Gln, Cys (CE). The cata...
Source: Mini Reviews in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: Igor Jos é Dos Santos Nascimento Joilly Nilce Santana Gomes J éssika de Oliveira Viana Yvnni Maria Sales de Medeiros E Silva Euz ébio Guimarães Barbosa Ricardo Olimpio de Moura Source Type: research

The application of MD simulation to lead identification, vaccine design, and structural studies in combat against leishmaniasis - A review
Mini Rev Med Chem. 2023 Sep 1. doi: 10.2174/1389557523666230901105231. Online ahead of print.ABSTRACTDrug discovery, vaccine design, and protein interaction studies are rapidly moving toward the routine use of molecular dynamics simulations (MDS) and related methods. As a result of MDS, it is possible to gain insights into the dynamics and function of identified drug targets, antibody-antigen interactions, potential vaccine candidates, intrinsically disordered proteins, and essential proteins. The MDS appears to be used in all possible ways in combating diseases such as cancer, however, it has not been well documented as t...
Source: Mini Reviews in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: Saravanan Vijayakumar Lukkani Laxman Kumar Subhomoi Borkotoky Ayaluru Murali Source Type: research

The Power of Molecular Dynamics Simulations and Their Applications to Discover Cysteine Protease Inhibitors
Mini Rev Med Chem. 2023 Sep 1. doi: 10.2174/1389557523666230901152257. Online ahead of print.ABSTRACTA large family of enzymes with the function of hydrolyzing peptide bonds, called peptidases or cysteine proteases (CPs), are divided into three categories according to the peptide chain involved. CPs catalyze the hydrolysis of amide, ester, thiol ester, and thioester peptide bonds. They can be divided into several groups, such as papain-like (CA), viral chymotrypsin-like CPs (CB), papain-like endopeptidases of RNA viruses (CC), legumain-type caspases (CD), and showing active residues of His, Glu/Asp, Gln, Cys (CE). The cata...
Source: Mini Reviews in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: Igor Jos é Dos Santos Nascimento Joilly Nilce Santana Gomes J éssika de Oliveira Viana Yvnni Maria Sales de Medeiros E Silva Euz ébio Guimarães Barbosa Ricardo Olimpio de Moura Source Type: research

The application of MD simulation to lead identification, vaccine design, and structural studies in combat against leishmaniasis - A review
Mini Rev Med Chem. 2023 Sep 1. doi: 10.2174/1389557523666230901105231. Online ahead of print.ABSTRACTDrug discovery, vaccine design, and protein interaction studies are rapidly moving toward the routine use of molecular dynamics simulations (MDS) and related methods. As a result of MDS, it is possible to gain insights into the dynamics and function of identified drug targets, antibody-antigen interactions, potential vaccine candidates, intrinsically disordered proteins, and essential proteins. The MDS appears to be used in all possible ways in combating diseases such as cancer, however, it has not been well documented as t...
Source: Mini Reviews in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: Saravanan Vijayakumar Lukkani Laxman Kumar Subhomoi Borkotoky Ayaluru Murali Source Type: research

The Power of Molecular Dynamics Simulations and Their Applications to Discover Cysteine Protease Inhibitors
Mini Rev Med Chem. 2023 Sep 1. doi: 10.2174/1389557523666230901152257. Online ahead of print.ABSTRACTA large family of enzymes with the function of hydrolyzing peptide bonds, called peptidases or cysteine proteases (CPs), are divided into three categories according to the peptide chain involved. CPs catalyze the hydrolysis of amide, ester, thiol ester, and thioester peptide bonds. They can be divided into several groups, such as papain-like (CA), viral chymotrypsin-like CPs (CB), papain-like endopeptidases of RNA viruses (CC), legumain-type caspases (CD), and showing active residues of His, Glu/Asp, Gln, Cys (CE). The cata...
Source: Mini Reviews in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: Igor Jos é Dos Santos Nascimento Joilly Nilce Santana Gomes J éssika de Oliveira Viana Yvnni Maria Sales de Medeiros E Silva Euz ébio Guimarães Barbosa Ricardo Olimpio de Moura Source Type: research

Research Progress of Tamarixetin and its glycosides
Mini Rev Med Chem. 2023 Aug 28. doi: 10.2174/1389557523666230828123425. Online ahead of print.ABSTRACTTamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, anti-inflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis. At the same time, research shows that tamarixetin is safe to use because it has little self-toxicity. In this paper, 181 articles on tamarixetin published from 1...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Cunbing Li Mengxin Tao Tingting Li Xiaofen Huang Hong Sui Xueyan Fu Source Type: research

The Critical Function of microRNAs in Developing Resistance against 5-Fluorouracil in Cancer Cells
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825144150. Online ahead of print.ABSTRACTAlthough there have been significant advancements in cancer treatment, resistance and recurrence in patients make it one of the leading causes of death worldwide. 5-fluorouracil (5-FU), an antimetabolite agent, is widely used in treating a broad range of human malignancies. The cytotoxic effects of 5-FU are mediated by the inhibition of thymidylate synthase (TYMS/TS), resulting in the suppression of essential biosynthetic activity, as well as the misincorporation of its metabolites into RNA and DNA. Despite its huge benefi...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Farhad Sheikhnia Hossein Maghsoudi Maryam Majidinia Source Type: research

DNA Methyltransferase 3A: a Significant Target for the Discovery of Inhibitors as Potent Anticancer Drugs
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825100246. Online ahead of print.ABSTRACTDNA methyltransferase (DNMT) is a conserved family of Cytosine methylases, which plays a crucial role in the regulation of Epigenetics. They have been considered promising therapeutic targets for cancer. Among the DNMT family, mutations in the DNMT3A subtype are particularly important in hematologic malignancies. The development of specific DNMT3A subtype inhibitors to validate the therapeutic potential of DNMT3A in certain diseases is a significant task. In this review, we summarized the small molecule inhibitors of DNMT3...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Qixun Feng Honggao Duan Xinglong Zhou Yuning Wang Jinda Zhang Haoge Zhang Guoliang Chen Xuefei Bao Source Type: research

Research Progress of Tamarixetin and its glycosides
Mini Rev Med Chem. 2023 Aug 28. doi: 10.2174/1389557523666230828123425. Online ahead of print.ABSTRACTTamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, anti-inflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis. At the same time, research shows that tamarixetin is safe to use because it has little self-toxicity. In this paper, 181 articles on tamarixetin published from 1...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Cunbing Li Mengxin Tao Tingting Li Xiaofen Huang Hong Sui Xueyan Fu Source Type: research

The Critical Function of microRNAs in Developing Resistance against 5-Fluorouracil in Cancer Cells
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825144150. Online ahead of print.ABSTRACTAlthough there have been significant advancements in cancer treatment, resistance and recurrence in patients make it one of the leading causes of death worldwide. 5-fluorouracil (5-FU), an antimetabolite agent, is widely used in treating a broad range of human malignancies. The cytotoxic effects of 5-FU are mediated by the inhibition of thymidylate synthase (TYMS/TS), resulting in the suppression of essential biosynthetic activity, as well as the misincorporation of its metabolites into RNA and DNA. Despite its huge benefi...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Farhad Sheikhnia Hossein Maghsoudi Maryam Majidinia Source Type: research

DNA Methyltransferase 3A: a Significant Target for the Discovery of Inhibitors as Potent Anticancer Drugs
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825100246. Online ahead of print.ABSTRACTDNA methyltransferase (DNMT) is a conserved family of Cytosine methylases, which plays a crucial role in the regulation of Epigenetics. They have been considered promising therapeutic targets for cancer. Among the DNMT family, mutations in the DNMT3A subtype are particularly important in hematologic malignancies. The development of specific DNMT3A subtype inhibitors to validate the therapeutic potential of DNMT3A in certain diseases is a significant task. In this review, we summarized the small molecule inhibitors of DNMT3...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Qixun Feng Honggao Duan Xinglong Zhou Yuning Wang Jinda Zhang Haoge Zhang Guoliang Chen Xuefei Bao Source Type: research

Research Progress of Tamarixetin and its glycosides
Mini Rev Med Chem. 2023 Aug 28. doi: 10.2174/1389557523666230828123425. Online ahead of print.ABSTRACTTamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, anti-inflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis. At the same time, research shows that tamarixetin is safe to use because it has little self-toxicity. In this paper, 181 articles on tamarixetin published from 1...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Cunbing Li Mengxin Tao Tingting Li Xiaofen Huang Hong Sui Xueyan Fu Source Type: research