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The Critical Function of microRNAs in Developing Resistance against 5-Fluorouracil in Cancer Cells
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825144150. Online ahead of print.ABSTRACTAlthough there have been significant advancements in cancer treatment, resistance and recurrence in patients make it one of the leading causes of death worldwide. 5-fluorouracil (5-FU), an antimetabolite agent, is widely used in treating a broad range of human malignancies. The cytotoxic effects of 5-FU are mediated by the inhibition of thymidylate synthase (TYMS/TS), resulting in the suppression of essential biosynthetic activity, as well as the misincorporation of its metabolites into RNA and DNA. Despite its huge benefi...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Farhad Sheikhnia Hossein Maghsoudi Maryam Majidinia Source Type: research

DNA Methyltransferase 3A: a Significant Target for the Discovery of Inhibitors as Potent Anticancer Drugs
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825100246. Online ahead of print.ABSTRACTDNA methyltransferase (DNMT) is a conserved family of Cytosine methylases, which plays a crucial role in the regulation of Epigenetics. They have been considered promising therapeutic targets for cancer. Among the DNMT family, mutations in the DNMT3A subtype are particularly important in hematologic malignancies. The development of specific DNMT3A subtype inhibitors to validate the therapeutic potential of DNMT3A in certain diseases is a significant task. In this review, we summarized the small molecule inhibitors of DNMT3...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Qixun Feng Honggao Duan Xinglong Zhou Yuning Wang Jinda Zhang Haoge Zhang Guoliang Chen Xuefei Bao Source Type: research

Research Progress of Tamarixetin and its glycosides
Mini Rev Med Chem. 2023 Aug 28. doi: 10.2174/1389557523666230828123425. Online ahead of print.ABSTRACTTamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, anti-inflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis. At the same time, research shows that tamarixetin is safe to use because it has little self-toxicity. In this paper, 181 articles on tamarixetin published from 1...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Cunbing Li Mengxin Tao Tingting Li Xiaofen Huang Hong Sui Xueyan Fu Source Type: research

The Critical Function of microRNAs in Developing Resistance against 5-Fluorouracil in Cancer Cells
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825144150. Online ahead of print.ABSTRACTAlthough there have been significant advancements in cancer treatment, resistance and recurrence in patients make it one of the leading causes of death worldwide. 5-fluorouracil (5-FU), an antimetabolite agent, is widely used in treating a broad range of human malignancies. The cytotoxic effects of 5-FU are mediated by the inhibition of thymidylate synthase (TYMS/TS), resulting in the suppression of essential biosynthetic activity, as well as the misincorporation of its metabolites into RNA and DNA. Despite its huge benefi...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Farhad Sheikhnia Hossein Maghsoudi Maryam Majidinia Source Type: research

DNA Methyltransferase 3A: a Significant Target for the Discovery of Inhibitors as Potent Anticancer Drugs
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825100246. Online ahead of print.ABSTRACTDNA methyltransferase (DNMT) is a conserved family of Cytosine methylases, which plays a crucial role in the regulation of Epigenetics. They have been considered promising therapeutic targets for cancer. Among the DNMT family, mutations in the DNMT3A subtype are particularly important in hematologic malignancies. The development of specific DNMT3A subtype inhibitors to validate the therapeutic potential of DNMT3A in certain diseases is a significant task. In this review, we summarized the small molecule inhibitors of DNMT3...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Qixun Feng Honggao Duan Xinglong Zhou Yuning Wang Jinda Zhang Haoge Zhang Guoliang Chen Xuefei Bao Source Type: research

Research Progress of Tamarixetin and its glycosides
Mini Rev Med Chem. 2023 Aug 28. doi: 10.2174/1389557523666230828123425. Online ahead of print.ABSTRACTTamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, anti-inflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis. At the same time, research shows that tamarixetin is safe to use because it has little self-toxicity. In this paper, 181 articles on tamarixetin published from 1...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Cunbing Li Mengxin Tao Tingting Li Xiaofen Huang Hong Sui Xueyan Fu Source Type: research

The Critical Function of microRNAs in Developing Resistance against 5-Fluorouracil in Cancer Cells
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825144150. Online ahead of print.ABSTRACTAlthough there have been significant advancements in cancer treatment, resistance and recurrence in patients make it one of the leading causes of death worldwide. 5-fluorouracil (5-FU), an antimetabolite agent, is widely used in treating a broad range of human malignancies. The cytotoxic effects of 5-FU are mediated by the inhibition of thymidylate synthase (TYMS/TS), resulting in the suppression of essential biosynthetic activity, as well as the misincorporation of its metabolites into RNA and DNA. Despite its huge benefi...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Farhad Sheikhnia Hossein Maghsoudi Maryam Majidinia Source Type: research

DNA Methyltransferase 3A: a Significant Target for the Discovery of Inhibitors as Potent Anticancer Drugs
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825100246. Online ahead of print.ABSTRACTDNA methyltransferase (DNMT) is a conserved family of Cytosine methylases, which plays a crucial role in the regulation of Epigenetics. They have been considered promising therapeutic targets for cancer. Among the DNMT family, mutations in the DNMT3A subtype are particularly important in hematologic malignancies. The development of specific DNMT3A subtype inhibitors to validate the therapeutic potential of DNMT3A in certain diseases is a significant task. In this review, we summarized the small molecule inhibitors of DNMT3...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Qixun Feng Honggao Duan Xinglong Zhou Yuning Wang Jinda Zhang Haoge Zhang Guoliang Chen Xuefei Bao Source Type: research

Research Progress of Tamarixetin and its glycosides
Mini Rev Med Chem. 2023 Aug 28. doi: 10.2174/1389557523666230828123425. Online ahead of print.ABSTRACTTamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, anti-inflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis. At the same time, research shows that tamarixetin is safe to use because it has little self-toxicity. In this paper, 181 articles on tamarixetin published from 1...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Cunbing Li Mengxin Tao Tingting Li Xiaofen Huang Hong Sui Xueyan Fu Source Type: research

The Critical Function of microRNAs in Developing Resistance against 5-Fluorouracil in Cancer Cells
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825144150. Online ahead of print.ABSTRACTAlthough there have been significant advancements in cancer treatment, resistance and recurrence in patients make it one of the leading causes of death worldwide. 5-fluorouracil (5-FU), an antimetabolite agent, is widely used in treating a broad range of human malignancies. The cytotoxic effects of 5-FU are mediated by the inhibition of thymidylate synthase (TYMS/TS), resulting in the suppression of essential biosynthetic activity, as well as the misincorporation of its metabolites into RNA and DNA. Despite its huge benefi...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Farhad Sheikhnia Hossein Maghsoudi Maryam Majidinia Source Type: research

DNA Methyltransferase 3A: a Significant Target for the Discovery of Inhibitors as Potent Anticancer Drugs
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825100246. Online ahead of print.ABSTRACTDNA methyltransferase (DNMT) is a conserved family of Cytosine methylases, which plays a crucial role in the regulation of Epigenetics. They have been considered promising therapeutic targets for cancer. Among the DNMT family, mutations in the DNMT3A subtype are particularly important in hematologic malignancies. The development of specific DNMT3A subtype inhibitors to validate the therapeutic potential of DNMT3A in certain diseases is a significant task. In this review, we summarized the small molecule inhibitors of DNMT3...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Qixun Feng Honggao Duan Xinglong Zhou Yuning Wang Jinda Zhang Haoge Zhang Guoliang Chen Xuefei Bao Source Type: research

Research Progress of Tamarixetin and its glycosides
Mini Rev Med Chem. 2023 Aug 28. doi: 10.2174/1389557523666230828123425. Online ahead of print.ABSTRACTTamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, anti-inflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis. At the same time, research shows that tamarixetin is safe to use because it has little self-toxicity. In this paper, 181 articles on tamarixetin published from 1...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Cunbing Li Mengxin Tao Tingting Li Xiaofen Huang Hong Sui Xueyan Fu Source Type: research

The Critical Function of microRNAs in Developing Resistance against 5-Fluorouracil in Cancer Cells
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825144150. Online ahead of print.ABSTRACTAlthough there have been significant advancements in cancer treatment, resistance and recurrence in patients make it one of the leading causes of death worldwide. 5-fluorouracil (5-FU), an antimetabolite agent, is widely used in treating a broad range of human malignancies. The cytotoxic effects of 5-FU are mediated by the inhibition of thymidylate synthase (TYMS/TS), resulting in the suppression of essential biosynthetic activity, as well as the misincorporation of its metabolites into RNA and DNA. Despite its huge benefi...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Farhad Sheikhnia Hossein Maghsoudi Maryam Majidinia Source Type: research

DNA Methyltransferase 3A: a Significant Target for the Discovery of Inhibitors as Potent Anticancer Drugs
Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825100246. Online ahead of print.ABSTRACTDNA methyltransferase (DNMT) is a conserved family of Cytosine methylases, which plays a crucial role in the regulation of Epigenetics. They have been considered promising therapeutic targets for cancer. Among the DNMT family, mutations in the DNMT3A subtype are particularly important in hematologic malignancies. The development of specific DNMT3A subtype inhibitors to validate the therapeutic potential of DNMT3A in certain diseases is a significant task. In this review, we summarized the small molecule inhibitors of DNMT3...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Qixun Feng Honggao Duan Xinglong Zhou Yuning Wang Jinda Zhang Haoge Zhang Guoliang Chen Xuefei Bao Source Type: research

Research Progress of Tamarixetin and its glycosides
Mini Rev Med Chem. 2023 Aug 28. doi: 10.2174/1389557523666230828123425. Online ahead of print.ABSTRACTTamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, anti-inflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis. At the same time, research shows that tamarixetin is safe to use because it has little self-toxicity. In this paper, 181 articles on tamarixetin published from 1...
Source: Mini Reviews in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Cunbing Li Mengxin Tao Tingting Li Xiaofen Huang Hong Sui Xueyan Fu Source Type: research