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Advances in the Synthesis and Bioactivity of Polysaccharide Selenium Nanoparticles: A Review
Mini Rev Med Chem. 2024 Feb 29. doi: 10.2174/0113895575302440240219053006. Online ahead of print.ABSTRACTSelenium, an essential trace element of the human body, is pivotal in human health and disease prevention. Nevertheless, the narrow therapeutic index of selenium, where the toxic and therapeutic doses are close, limits its clinical utility. Significantly, nanoscale selenium synthesized by different methods using polysaccharides as stabilizers has low toxicity properties and exhibits excellent bioactivity. Its biological activities, such as anti-tumor, anti-inflammatory, antioxidant, antibacterial, and immune function en...
Source: Mini Reviews in Medicinal Chemistry - March 1, 2024 Category: Chemistry Authors: Shiying Ye Shaowei Sun Jiye Cai Jinhuan Jiang Source Type: research

Mini-Review on Vitamin D in Pediatric Population and its Role in Respiratory and Atopic Disorders
Mini Rev Med Chem. 2024 Feb 20. doi: 10.2174/0113895575284873240212045431. Online ahead of print.ABSTRACTIn recent years, our comprehension of the function of vitamin D has significantly evolved. The ubiquitous presence of the vitamin D receptor (Vitamin D Receptor- VDR) in the body has led to its redefinition from a steroidal hormone primarily involved in skeletal functions to a hormone with pleiotropic effects, exerting its influence on the circulatory, nervous, and immune systems. This has prompted investigations into its potential use in preventing and treating chronic metabolic disorders, cardiovascular diseases, infe...
Source: Mini Reviews in Medicinal Chemistry - February 28, 2024 Category: Chemistry Authors: Cristiana Indolfi Angela Klain Giulio Dinardo Fabio Decimo Maria Maddalena Marrapodi Amelia Licari Michele Miraglia Del Giudice Source Type: research

The Emergence of N. sativa L. as a Green Antifungal Agent
CONCLUSION: The review provides an in-depth analysis of the antifungal activity of black cumin. This work emphasizes the need to expand studies on this plant to exploit its antifungal properties for biomedical applications.PMID:38409693 | DOI:10.2174/0113895575282914240217060251 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - February 27, 2024 Category: Chemistry Authors: Raghvendra Pandey Brijesh Pandey Atul Bhargava Source Type: research

Dietary Plant Metabolites Induced Epigenetic Modification as a Novel Strategy for the Management of Prostate Cancer
Mini Rev Med Chem. 2024 Feb 21. doi: 10.2174/0113895575283895240207065454. Online ahead of print.ABSTRACTProstate cancer is a widespread malignancy among men, with a substantial global impact on morbidity and mortality. Despite advances in conventional therapies, the need for innovative and less toxic treatments remains a priority. Emerging evidence suggests that dietary plant metabolites possess epigenetic-modifying properties, making them attractive candidates for prostate cancer treatment. The present work reviews the epigenetic effects of dietary plant metabolites in the context of prostate cancer therapy. We first out...
Source: Mini Reviews in Medicinal Chemistry - February 22, 2024 Category: Chemistry Authors: Vaibhav Singh Ekta Shirbhate Rakesh Kore Aditya Mishra Varsha Johariya Ravichandran Veerasamy Amit K Tiwari Harish Rajak Source Type: research