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The Role of Extracellular Vesicles in Efferocytosis
Mini Rev Med Chem. 2023 Oct 5. doi: 10.2174/0113895575247690230926113455. Online ahead of print.ABSTRACTEfferocytosis is the physiological process of phagocytic clearance of apoptotic cells by both professional phagocytic cells, such as macrophages, and non-professional phagocytic cells, such as epithelial cells. This process is crucial for maintaining tissue homeostasis in normal physiology. Any defects in efferocytosis can lead to pathological consequences and result in inflammatory diseases. Extracellular vesicles (EVs), including exosomes, microvesicles (MVs), and apoptotic vesicles (ApoVs), play a crucial role in prop...
Source: Mini Reviews in Medicinal Chemistry - October 20, 2023 Category: Chemistry Authors: Susan Panahi Zohreh Yazdi Mahboubeh Sanchouli Fatemehsadat Sajadi Fateme Motavasselian Hedyeh Maghareh Abed Zahra Beygi Seyed Mohammad Gheibihayat Source Type: research

Roles of lncRNA-MALAT1 in the Progression and Prognosis of Gliomas
Mini Rev Med Chem. 2023 Oct 6. doi: 10.2174/0113895575253875230922055711. Online ahead of print.ABSTRACTLong noncoding RNAs (lncRNAs) represent a large subgroup of RNA transcripts that lack the function of coding proteins and may be essential universal genes involved in carcinogenesis and metastasis. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNAMALAT1) is overexpressed in various human tumors, including gliomas. However, the biological function and molecular mechanism of action of lncRNA-MALAT1 in gliomas have not yet been systematically elucidated. Accumulating evidence suggests that the abnormal e...
Source: Mini Reviews in Medicinal Chemistry - October 20, 2023 Category: Chemistry Authors: Da-Peng Wang Yu-Long Ji Qiao-Li Lv Kai Kang Source Type: research

Mitochondrial Dysfunction and Imeglimin: A New Ray of Hope for the Treatment of Type-2 Diabetes Mellitus
Mini Rev Med Chem. 2023 Oct 10. doi: 10.2174/0113895575260225230921062013. Online ahead of print.ABSTRACTDiabetes is a rapidly growing health challenge and epidemic in many developing countries, including India. India, being the diabetes capital of the world, has the dubious dual distinction of being the leading nations for both undernutrition and overnutrition. Diabetes prevalence has increased in both rural and urban areas, affected the younger population and increased the risk of complications and economic burden. These alarming statistics ring an alarm bell to achieve glycemic targets in the affected population in orde...
Source: Mini Reviews in Medicinal Chemistry - October 20, 2023 Category: Chemistry Authors: Jayshree Swain Pooja Jadhao Surapaneni Lakshmi Sravya Brij Teli Kasukurti Lavanya Jaspreet Singh Abhay Sahoo Srijit Das Source Type: research

Cortisol as a Target for Treating Mental Disorders: A Promising Avenue for Therapy
Mini Rev Med Chem. 2023 Oct 10. doi: 10.2174/0113895575262104230928042150. Online ahead of print.ABSTRACTCortisol, commonly known as the "stress hormone," plays a critical role in the body's response to stress. Elevated cortisol levels have been associated with various mental disorders, including anxiety, depression, and post-traumatic stress disorder. Consequently, researchers have explored cortisol modulation as a promising avenue for treating these conditions. However, the availability of research on cortisol as a therapeutic option for mental disorders is limited, and existing studies employ diverse methodologies and o...
Source: Mini Reviews in Medicinal Chemistry - October 20, 2023 Category: Chemistry Authors: Vijay Patel Aayush Vaishnaw Ekta Shirbhate Rakesh Kore Vaibhav Singh Ravichandran Veerasamy Harish Rajak Source Type: research

Role of Flavonoids in Modulation of Mitochondria Dynamics during Oxidative Stress
CONCLUSION: This review may provide a solid foundation for developing targeted therapeutic interventions utilizing flavonoids, ultimately benefiting individuals afflicted with various disorders.PMID:37861054 | DOI:10.2174/0113895575259219230920093214 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - October 20, 2023 Category: Chemistry Authors: Sachindra Kumar Vishal Chhabra Smita Shenoy Rajni Daksh Velayutham Ravichandiran Ravindra Swamy Nitesh Kumar Source Type: research