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The Effects of Apigenin in the Treatment of Diabetic Nephropathy: A Systematic Review of Non-clinical Studies
CONCLUSION: The results indicated that the use of apigenin could mitigate diabetes-induced renal adverse effects, mainly through its antioxidant, anti-apoptotic, and anti-inflammatory activities. Since the findings of this study are based on experimental studies, suggesting the use of apigenin (as a nephroprotective agent) against diabetic nephropathy requires further clinical studies.PMID:38282447 | DOI:10.2174/1389557523666230811092423 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - January 29, 2024 Category: Chemistry Authors: Thikra Majid Muhammed Abduladheem Turki Jalil Waam Mohammed Taher Zafar Aminov Fahad Alsaikhan Andr és Alexis Ramírez-Coronel Pushpamala Ramaiah Bagher Farhood Source Type: research

Targeting Ferroptosis: A Novel Strategy for the Treatment of Atherosclerosis
Mini Rev Med Chem. 2024 Jan 26. doi: 10.2174/0113895575273164231130070920. Online ahead of print.ABSTRACTSince ferroptosis was reported in 2012, its application prospects in various diseases have been widely considered, initially as a treatment direction for tumors. Recent studies have shown that ferroptosis is closely related to the occurrence and development of atherosclerosis. The primary mechanism is to affect the occurrence and development of atherosclerosis through intracellular iron homeostasis, ROS and lipid peroxide production and metabolism, and a variety of intracellular signaling pathways. Inhibition of ferropt...
Source: Mini Reviews in Medicinal Chemistry - January 29, 2024 Category: Chemistry Authors: Yifan Zhang Chengshi Jiang Ning Meng Source Type: research

Calcium Modulating Effect of Polycyclic Cages: A Suitable Therapeutic Approach Against Excitotoxic-induced Neurodegeneration
Mini Rev Med Chem. 2024 Jan 24. doi: 10.2174/0113895575273868231128104121. Online ahead of print.ABSTRACTNeurodegenerative disorders pose a significant challenge to global healthcare systems due to their progressive nature and the resulting loss of neuronal cells and functions. Excitotoxicity, characterized by calcium overload, plays a critical role in the pathophysiology of these disorders. In this review article, we explore the involvement of calcium dysregulation in neurodegeneration and neurodegenerative disorders. A promising therapeutic strategy to counter calcium dysregulation involves the use of calcium modulators,...
Source: Mini Reviews in Medicinal Chemistry - January 26, 2024 Category: Chemistry Authors: Ayodeji O Egunlusi Sarel F Malan Vitalii A Palchykov Jacques Joubert Source Type: research

A Review on Chemical Structures and Biological Activities of Dopamine Derivatives from Medicinal Insects
Mini Rev Med Chem. 2024 Jan 23. doi: 10.2174/0113895575273335231128080705. Online ahead of print.ABSTRACTMedicinal insects play an important role in the treatment of refractory diseases due to their unique and rich pharmacological activities. However, compared to plants, microorganisms, and marine organisms, medicinal insects have been largely ignored. Some small molecules isolated from insects are known to have defensive effects, but their majority roles remain unknown. In-depth research on the small molecules of medicinal insects has been conducted in recent years. Then alkaloids, dopamine derivatives, nucleoside derivat...
Source: Mini Reviews in Medicinal Chemistry - January 26, 2024 Category: Chemistry Authors: Wen-Jun Wei Dong-Ge Wang Meng-Shan Ji Tao Guo Source Type: research

SMAC Mimetics for the Treatment of Lung Carcinoma: Present Development and Future Prospects
CONCLUSION: SMAC mimetics acts in a restorative way in the prevention of lung cancer.PMID:38275029 | DOI:10.2174/0113895575269644231120104501 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - January 26, 2024 Category: Chemistry Authors: Ruchi Pandey Priya Bisht Pranay Wal Krishna Murti V Ravichandiran Nitesh Kumar Source Type: research

Roles of Accelerated Molecular Dynamics Simulations in Predictions of Binding Kinetic Parameters
Mini Rev Med Chem. 2024 Jan 23. doi: 10.2174/0113895575252165231122095555. Online ahead of print.ABSTRACTRational predictions on binding kinetics parameters of drugs to targets play significant roles in future drug designs. Full conformational samplings of targets are requisite for accurate predictions of binding kinetic parameters. In this review, we mainly focus on the applications of enhanced sampling technologies in calculations of binding kinetics parameters and residence time of drugs. The methods involved in molecular dynamics simulations are applied to not only probe conformational changes of targets but also revea...
Source: Mini Reviews in Medicinal Chemistry - January 24, 2024 Category: Chemistry Authors: Jianzhong Chen Wei Wang Haibo Sun Weikai He Source Type: research

Bioactivities and Structure-Activity Relationships of Usnic Acid Derivatives: A Review
Mini Rev Med Chem. 2024 Jan 23. doi: 10.2174/0113895575277085231123165546. Online ahead of print.ABSTRACTUsnic acid has a variety of biological activities, and has been widely studied in the fields of antibacterial, immune stimulation, antiviral, antifungal, anti-inflammatory and antiparasitic. Based on this, usnic acid is used as the lead compound for structural modification. In order to enhance the biological activity and solubility of usnic acid, scholars have carried out a large number of structural modifications, and found some usnic acid derivatives to be of more potential research value. In this paper, the structura...
Source: Mini Reviews in Medicinal Chemistry - January 24, 2024 Category: Chemistry Authors: Wen-Zhe Nie Qing-Kun Shen Zhe-Shan Quan Hong-Yan Guo Ya-Mei Li Source Type: research

Targeted Inhibition of the PI3K/Akt/mTOR Signaling Axis: Potential for Sarcoma Therapy
Mini Rev Med Chem. 2024 Jan 23. doi: 10.2174/0113895575270904231129062137. Online ahead of print.ABSTRACTSarcoma is a heterogeneous group of malignancies often resistant to conventional chemotherapy and radiation therapy. The phosphatidylinositol-3-kinase/ protein kinase B /mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway has emerged as a critical cancer target due to its central role in regulating key cellular processes such as cell growth, proliferation, survival, and metabolism. Dysregulation of this pathway has been implicated in the development and progression of bone sarcomas (BS) and soft tissue sarco...
Source: Mini Reviews in Medicinal Chemistry - January 24, 2024 Category: Chemistry Authors: Atif Khurshid Wani Reena Singh Nahid Akhtar Ajit Prakash Eugenie Nepovimova Patrik Oleksak Zofia Chrienova Suliman Alomar Chirag Chopra Kamil Kuca Source Type: research

Enhanced Sampling in Molecular Dynamics Simulations: How Many MD Snapshots can be Needed to Reproduce the Biological Behavior?
Mini Rev Med Chem. 2024 Jan 22. doi: 10.2174/0113895575250433231103063707. Online ahead of print.ABSTRACTSince its early days in the 19th century, medicinal chemistry has concentrated its efforts on the treatment of diseases, using tools from areas such as chemistry, pharmacology, and molecular biology. The understanding of biological mechanisms and signaling pathways is crucial information for the development of potential agents for the treatment of diseases mainly because they are such complex processes. Given the limitations that the experimental approach presents, computational chemistry is a valuable alternative for t...
Source: Mini Reviews in Medicinal Chemistry - January 23, 2024 Category: Chemistry Authors: Camila A Tavares Tain áh M R Santos Mateus A Gon çalves Elaine F F da Cunha Teodorico C Ramalho Source Type: research

Artificial Intelligence in Drug Discovery: A Bibliometric Analysis and Literature Review
Mini Rev Med Chem. 2024 Jan 12. doi: 10.2174/0113895575271267231123160503. Online ahead of print.ABSTRACTDrug discovery is a complex and iterative process, making it ideal for using artificial intelligence (AI). This paper uses a bibliometric approach to reveal AI's trend and underlying structure in drug discovery (AIDD). A total of 4310 journal articles and reviews indexed in Scopus were analyzed, revealing that AIDD has been rapidly growing over the past two decades, with a significant increase after 2017. The United States, China, and the United Kingdom were the leading countries in research output, with academic instit...
Source: Mini Reviews in Medicinal Chemistry - January 20, 2024 Category: Chemistry Authors: Baoyu He Jingjing Guo Henry H Y Tong Wai Ming To Source Type: research

An In Silico Approach to Exploring the Antinociceptive Biological Activities of Linalool and its Metabolites
Mini Rev Med Chem. 2024 Jan 15. doi: 10.2174/0113895575261945231122062659. Online ahead of print.ABSTRACTPain is characterized by the unpleasant sensory and emotional sensation associated with actual or potential tissue damage, whereas nociception refers to the mechanism by which noxious stimuli are transmitted from the periphery to the CNS. The main drugs used to treat pain are nonsteroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics, which have side effects that limit their use. Therefore, in the search for new drugs with potential antinociceptive effects, essential oils have been studied, whose constituents (...
Source: Mini Reviews in Medicinal Chemistry - January 20, 2024 Category: Chemistry Authors: Pablo Rayff da Silva Natalia Diniz Nunes Pazos J éssica Cabral de Andrade Nat ália Ferreira de Sousa Hugo Fernandes Oliveira Pires Jaisl ânia Lucena de Figueiredo Lima Arthur Lins Dias Mirian Graciela da Silva Stiebbe Salvadori Adriana Maria Fernandes Source Type: research

Ferroptosis is Involved in the Pharmacological Effect of Ginsenoside
This article examines the molecular mechanism of ferroptosis as well as the current advancement of ginsenoside in influencing disorders via ferroptosis.PMID:38213172 | DOI:10.2174/0113895575277359231210145922 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - January 12, 2024 Category: Chemistry Authors: Juling Feng Haodong Chen Yangbo Liu Qidi Ai Yantao Yang Wenbin He Lei Zhao Shifeng Chu Naihong Chen Source Type: research

Quinoline Derivatives as Promising Scaffolds for Antitubercular Activity: A Comprehensive Review
CONCLUSION: This review highlights quinoline derivatives' antitubercular potential, emphasizing recent research advancements. Utilizing IC50 values, the study underscores the efficacy of various quinoline substitutions, hybrids, and electron-withdrawing groups against MTB H37Rv. Continued research is essential for developing potent, low-toxicity quinoline derivatives to combat tuberculosis.PMID:38185891 | DOI:10.2174/0113895575281039231218112953 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - January 8, 2024 Category: Chemistry Authors: Mohammad Owais Arun Kumar Syed Misbahul Hasan Kuldeep Singh Iqbal Azad Arshad Hussain None Suvaiv Mohd Akil Source Type: research