Real World Experience With Ustekinumab in Children and Young Adults at a Tertiary Care Pediatric Inflammatory Bowel Disease Center
Conclusions: Our results suggest that ustekinumab is efficacious and safe in pediatric patients with IBD. Controlled clinical trial data are needed to confirm these observations. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - June 23, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Avoidant/Restrictive Food Intake Disorder in Diet-treated Children With Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is an inflammatory condition of the esophagus with rising incidence in children. Owed to potential adverse effects and high costs of EoE medications, strict elimination diets are often employed as a mainstay of long-term EoE therapy in children. Currently, there are no effective tests to pinpoint food protein triggers in children with EoE. Therefore, EoE elimination diets are often broad (including milk, soy, wheat, egg, fish/shellfish, and nuts) and can greatly alter a child's baseline eating habits. Herein, we describe 2 cases of avoidant/restrictive food intake disorder (ARFID) in children...
Source: Journal of Pediatric Gastroenterology and Nutrition - June 23, 2019 Category: Gastroenterology Tags: Short Communication: Gastroenterology: Eosinophilic GI Disorders Source Type: research

Prevalence of Eosinophilic Esophagitis in Adolescents With Esophageal Atresia
Conclusion: In our series of 63 patients born with EA, mainly distal tracheoesophageal fistula, the prevalence of EoE is increased, and therefore should be considered in adolescents with EA. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - June 23, 2019 Category: Gastroenterology Tags: Original Article: Gastroenterology: Eosinophilic GI Disorders Source Type: research

Should Proton Pump Inhibitors be Systematically Prescribed in Patients With Esophageal Atresia After Surgical Repair?
Conclusions: PPI treatment does not prevent the formation of anastomotic strictures and appears to be over-prescribed in children with airway symptoms because of tracheomalacia. This suggests that PPI treatment could be prescribed more selectively. Close monitoring and long-term follow-up, however, of these vulnerable patients in specialized multidisciplinary clinics is imperative. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - June 23, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

HLA-DQ Genotyping, Duodenal Histology, and Response to Exclusion Diet in Autistic Children With Gastrointestinal Symptoms
Conclusions: Our data suggest that children with ASD with GI symptoms have a high prevalence of duodenal intraepithelial lymphocytic infiltration, which seems to be linked to a mechanism other than autoimmune response to gluten consumption. Alteration of duodenal histology, but not the HLA-DQ2/DQ8 status, was associated with clinical response to the diet. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - June 23, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Characterization of Esophageal Motility in Infants With Congenital Diaphragmatic Hernia Using High-resolution Manometry
Conclusions: Normal esophageal wave patterns are present in the investigated patients with iCDH. EGJ end-expiratory pressure seems lower in patients with iCDH without patch suggesting a decreased EGJ barrier function hence increased vulnerability to gastroesophageal reflux. Patch repair appears to increase end-expiratory pressure at the EGJ above that of controls suggesting that patch surgery tightens the EGJ, thereby increasing flow resistance. This is in line with the increased Pressure Flow Index. In infants with a patch, the inspiration-expiration pressure difference is lower, reflecting diminished activity of the cr...
Source: Journal of Pediatric Gastroenterology and Nutrition - June 23, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Pediatric Endoscopy Practice Patterns in the United States, Canada, and Mexico
Background and Aims: Endoscopic procedures are important for diagnosis and management of many gastrointestinal, liver, and biliary conditions in children. Therapeutic endoscopy procedures, including endoscopic retrograde cholangiopancreatography (ERCP), are performed less frequently in children relative to adults. A formal study to evaluate institutional volumes and practice patterns for advanced therapeutic pediatric endoscopy procedures has, however, not been previously undertaken. Methods: A self-administered 16-question (5-minute) online survey assessing practice patterns for performance of pediatric endoscopy pro...
Source: Journal of Pediatric Gastroenterology and Nutrition - June 23, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Paediatric Colonoscopy Direct Observation of Procedural Skills: Evidence of Validity and Competency Development
Introduction: The paediatric series of direct observation of procedural skills (DOPS) were introduced into the UK national endoscopy training curriculum in 2016, but lack validity evidence. We aimed to present validity evidence for paediatric colonoscopy DOPS and study competency development in a national trainee cohort. Methods: This prospective UK-wide study analysed formative paediatric colonoscopy DOPS which were submitted to the e-Portfolio between 2016 and 2018. Item, domain, and average DOPS scores were correlated with the overall DOPS rating to evidence internal structure validity. Overall DOPS ratings were co...
Source: Journal of Pediatric Gastroenterology and Nutrition - June 23, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Magnetically Controlled Capsule Endoscopy in Children: A Single-center, Retrospective Cohort Study
Conclusions: We showed that MCE is feasible and safe in children above 6 years. More studies are needed to further investigate the efficacy of MCE in children. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - June 23, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Sub-10-minute High-quality Diagnostic Colonoscopy With Terminal Ileum Intubation in Children Is Feasible and Safe
Conclusions: In conclusion, appropriately targeted IC in the management of children with GI symptoms is a safe, fast, and useful investigation. TI intubation rates of 100% are achievable and desirable and can be conducted quickly. Poor bowel preparation impacts negatively on this and IC duration may be faster in younger children. High diagnostic yields have been recorded in patients with a clinical suspicion of IBD. Diagnostic yield in isolated recurrent abdominal pain is low. Training to excellence in pediatric IC should be a persistent goal. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - June 23, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Sedation and the Food and Drug Administration Warning: What a Pediatric Gastroenterologist, Hepatologist, and Pancreatologist Should Know
Pediatric gastroenterologists recommend and perform a range of procedures requiring sedation and anesthesia in young children. A recent warning from the US Food and Drug Administration (FDA) states that “repeated or lengthy use of general anesthetics and sedation drugs during surgeries or procedures in children younger than 3 years or in pregnant women during their third trimester may affect the development of children's brains.” 1 As it relates to time, the FDA warning details risks of “procedures lasting longer than 3 hours or if multiple procedures are required.” Pediatric gastroenterologists a...
Source: Journal of Pediatric Gastroenterology and Nutrition - June 23, 2019 Category: Gastroenterology Tags: Topic of the Month Source Type: research

Commentary: Monitoring Thiopurine Efficacy Without Levels: Is It a Good Idea?
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - June 23, 2019 Category: Gastroenterology Tags: Invited Commentary Source Type: research

A Unified Treatment Algorithm and Admission Order Set for Pediatric Acute Pancreatitis
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Letter to the Editor Re: Serum Calprotectin in Adolescents With Inflammatory Bowel Disease
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Application of Whole Exome Sequencing in Congenital Secretory Diarrhea Diagnosis
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Case Report Source Type: research

Endoscopic Findings in Lysosomal Acid Lipase Deficiency
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Image of the Month Source Type: research

Neonatal Liver Failure With Hemophagocytosis and Skin Rash
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Image of the Month Source Type: research

Variables Impacting the Time Taken to Wean Children From Enteral Tube Feeding to Oral Intake
Conclusions: Biological factors usually considered to impact on successful weaning from tube feeding (volume of oral intake, oral skill, or mealtime behaviours) were not relevant; however, the type of feeding tube in combination with the degree of medical complexity and time tube fed were the strongest predictors. The impact of psychosocial factors should be investigated to identify if these mitigated the effects of the biological variables. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Zinc Absorption and Endogenous Fecal Zinc Losses in Bangladeshi Toddlers at Risk for Environmental Enteric Dysfunction
We examined zinc absorption from a standardized aqueous zinc dose, and habitual daily endogenous fecal zinc excretion (EFZ) and compared these outcomes between children grouped by the lactulose to mannitol ratio (L:M). Methods: Bangladeshi toddlers (18–24 months) with low ( (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Energy Balance in Critically Ill Children With Severe Sepsis Using Indirect Calorimetry: A Prospective Cohort Study
Conclusions: Persistent negative energy and nitrogen balance exist during acute phase of severe sepsis. Predictive equations are inaccurate compared with IC as the criterion standard. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Mixed Lipid, Fish Oil, and Soybean Oil Parenteral Lipids Impact Cholestasis, Hepatic Phytosterol, and Lipid Composition
Objectives: In parenteral nutrition-dependent infants and children, intestinal failure (IF)-associated liver disease (IFALD) remains an important problem. A comparative study was undertaken of parenteral mixed lipid (ML), ω-3 predominant fish oil (FO), and ω-6 predominant soybean oil (SO) emulsions in regards to hepatic phytosterol, neutral lipid, fatty acid (FA) content, and the relationship to cholestasis in piglets. Methods: Neonatal piglets received parenteral nutrition, varying in lipid dose (5 or 10 g· kg−1 · day−1) and formulation: SO5 (n = 5), SO10 (n = 5),...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Isolated Amylase Deficiency in Children and Its Clinical Implication
Conclusions: The prevalence of selective amylase deficiency was 10.1% in the 712 children who underwent ePFT with the suspicion of malabsorption. Low amylase activity is “physiologic” in infants (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Article: Pancreatology Source Type: research

Adequate Infliximab Exposure During Induction Predicts Remission in Paediatric Patients With Inflammatory Bowel Disease
Objectives: Therapeutic drug monitoring has been proposed as a useful tool in the management of infliximab (IFX) treated patients with inflammatory bowel disease. The aim of this retrospective study was to determine whether IFX trough levels after induction therapy are predictive for outcome at week 52. Methods: All pediatric patients with inflammatory bowel disease receiving maintenance IFX at our centre, with IFX trough level available at their first maintenance infusion and a follow-up of at least 52 weeks were included. IFX induction regimens could be intensified at the discretion of the treating physician. All ch...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Predictors of Long-term Clinical and Endoscopic Remission in Children With Crohn Disease Treated With Infliximab
Conclusions: Post induction FC combined with wPCDAI can predict 1-year clinical and endoscopic response to IFX in pediatric CD. FC shows a moderate correlation with SES-CD, whereas wPCDAI has a good concordance with endoscopic remission or severe disease, but not with mild and moderate disease. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Microscopic/“Backwash” Ileitis and Its Association With Colonic Disease in New Onset Pediatric Ulcerative Colitis
Conclusion: Patients with new onset UC may have microscopic ileal inflammation at time of diagnosis, even if the terminal ileum appears macroscopically normal. The presence of endoscopic pancolitis is associated with the presence of histologic ileitis. In contrast to existing studies in adults, an association between the presence of ileitis and the histologic severity or the histologic extent of colitis was not observed. Children with microscopic ileitis in the context of UC do not need to be reclassified as “indeterminate colitis” or Crohn disease. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Change in Prevalence of Family History During Long-term Follow-up of Patients With Pediatric-onset Inflammatory Bowel Disease
Objectives: The aim of the study was to prospectively study changes in prevalence of positive family history (FH+) in pediatric-onset inflammatory bowel disease (IBD) in contrast to previously published cross-sectional data. Methods: An observational cohort study was performed using a prospective pediatric-onset IBD database including 485 patients with disease duration ≥10 years as of December 2016. Proband characteristics and FH+ were obtained at diagnosis and subsequently from the database, medical records, and follow-up telephone interviews in 2006 and 2016. Results: Updated 2016 information was obtained from...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Clinical and Endoscopy Findings in Children With Accidental Exposure to Concentrated Detergent Pods
Conclusions: Our results suggest that oropharyngeal examination findings increase the likelihood of endoscopy findings; hence, we recommend endoscopic evaluation of patients who have examination findings secondary to exposure to CDPs. In other patients, it will be reasonable to evaluate the need for endoscopy on a case-by-case basis. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Insights Into Pediatric Autoimmune Gastritis: Is There a Role for: Helicobacter pylori: Infection?
Conclusions: Our findings highlight that AIG may have an age-dependent presentation; thus, we can consider a pediatric phenotype that in contrast to adults, is manifested by refractory iron-deficient anemia and associated with parietal cell autoantibody positivity, but not intrinsic factor autoantibodies. A correlation between H pylori and AIG was not evident in the current study and it is still unclear whether H pylori is a trigger for AIG. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Impact of Breast Milk, Respiratory Insufficiency, and Gastroesophageal Reflux Disease on Enteral Feeding in Infants With Omphalocele
Objectives: The aim of this study was to document the process of achieving full enteral feeding in infants with omphalocele and to identify factors that affect feeding success. Methods: After institutional review board approval (study no. 5100169), 123 infants with omphalocele, born between 1993 and 2011 were reviewed. Mortalities were excluded. All survivors had complete follow-up. Variables suspected to impact enteral feeding in infants with non-giant versus giant omphalocele were compared. Independent t test, Mann-Whitney, and χ2 test were used. Regression evaluated for variable independence. Results: Of 123...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Psychologic Distress and Anxiety in Mothers of Children With Gastroesophageal Reflux Undergoing Antireflux Surgery
Conclusions: Mothers of children undergoing antireflux surgery reported reduced levels of psychological distress and state anxiety 12 months after the operation. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Prevalence of Gastroesophageal Reflux Disease Symptoms in Infants and Children: A Systematic Review
Conclusions: This systematic review demonstrates that the reported prevalence of GERD symptoms varies considerably, depending on method of data collection and criteria used to define symptoms. Nevertheless, the high reported prevalence rates support better investment of resources and educational campaigns focused on prevention. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Barriers in Neurogastroenterology and Motility Training Experience for Pediatric Gastroenterology Fellows
Conclusions: Although most pediatric gastroenterology fellows expressed interest in NGM, the lack of exposure and dedicated training in motility during fellowship were identified as barriers to pursuing motility-focused careers. Furthermore, most fellows reported limited comfort with performing and/or interpreting motility studies. Changes are needed to encourage fellows to develop their interest and expertise in NGM. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Biliary Tract Disease in Girls and Young Women With Rett Syndrome
Objective: We reviewed medical records and conducted a nationwide survey to characterize the clinical features and determine the prevalence of biliary tract disease in girls and women with Rett syndrome (RTT). Methods: Sixty-two individuals with RTT and biliary tract disease were identified from the membership of Rett Syndrome Organization and patient files of the principal investigator. Medical records of 46 individuals were reviewed for presenting features, diagnostic tests, and treatment outcomes of biliary tract disease. We designed a questionnaire that probed the frequency of risk factors and treatment outcomes o...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Gallbladder Polyps: Rare Lesions in Childhood
Conclusion: In this study, GPs could be seen in young children as young as 16 months of age and ultrasonography is sufficient for follow-up in stable and asymptomatic patients. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Partial Splenic Embolization Is a Safe and Effective Alternative in the Management of Portal Hypertension in Children
Conclusions: PSE is a safe and effective alternative in the management of pediatric PHTN in select populations. PSE may be a favorable alternative to splenectomy and portal systemic shunting because it preserves functional spleen mass and avoids postprocedure accelerated liver disease or encephalopathy. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Hepatic Venous Pressure Gradient Measurements in Children: Correlation With Hepatic Histology and Clinical Indicators of Portal Hypertension
Conclusions: HVPG measurements do not correlate significantly with the degree of hepatic fibrosis on biopsy. Furthermore, HVPG measurements are not associated with the presence of varices or history of variceal bleeding, suggesting the possibility of intrahepatic shunting in children with advanced liver disease. Therefore, unlike in adults, HVPG measurements may not accurately predict children who are at risk of complications from portal hypertension. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Free-breathing Magnetic Resonance Imaging Assessment of Body Composition in Healthy and Overweight Children: An Observational Study
This study's objective was to use free-breathing MRI to quantify visceral and subcutaneous fat volumes and PDFFs and correlate these measurements with hepatic PDFF. Methods: This was an observational, hypothesis-forming study that enrolled 2 groups of children (ages 6–17 years), healthy children and overweight children with presumed nonalcoholic fatty liver disease. Free-breathing MRI was used to measure visceral and subcutaneous fat volumes and PDFFs, and hepatic PDFF. Imaging biomarkers were compared between groups, and correlations coefficients (r) and coefficients of determination (R2) were calculated. Result...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Magnetic Resonance Imaging: A Personalized Approach to Understanding Fatty Liver Disease
Conclusions: Personalized images of fatty liver were effective visualization tools for parents/caretakers to comprehend NAFLD and comprehension was not compromised by health literacy. Clear visual instruments may improve parent/caretaker comprehension of these conditions and may help to address deficiencies in health literacy. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Assessment of Exocrine Pancreatic Function During Endoscopy in Children
This article will review briefly the physiology of pancreatic enzyme secretion and the role of stimulated endoscopic testing for assessing exocrine pancreatic function. Published studies in both the pediatric and adult literature are reviewed. The technique and utility of endoscopic pancreatic function testing as the method of choice in the differential diagnosis of pancreatic disorders in childhood is described. Finally, emerging, clinically useful markers that can be measured in the pancreatic fluid will be described. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Review Article Source Type: research

Clinically Evident Portal Hypertension: An Operational Research Definition for Future Investigations in the Pediatric Population
Portal hypertension (PHT) is a major cause of morbidity and mortality in pediatric liver diseases. Thus, research into causes and disease modifiers in PHT in these conditions is vitally important. PHT is rarely directly or indirectly measured in the assessment of children with chronic liver disease. A straightforward, reproducible definition of PHT could be invaluable for consistently identifying patients with PHT and for grouping these patients according to their risk of complications from their disease. We propose the term Clinically Evident Portal Hypertension (CEPH) to denote clinical findings that demonstrate evidence...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Special Feature Source Type: research

A Path to Consensus on Endoscopic Pancreatic Function Testing
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Invited Commentaries Source Type: research

Deepening the Understanding of Functional and Motility Disorders
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Invited Commentaries Source Type: research

Efficacy of Vedolizumab for Inflammatory Bowel Disease in the Setting of DiGeorge Syndrome
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - April 26, 2019 Category: Gastroenterology Tags: Letter to the Editor Source Type: research

Multiorgan Transplantation as a Viable Treatment Option in Infantile Juvenile Polyposis Syndrome
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - April 26, 2019 Category: Gastroenterology Tags: Case Report Source Type: research

Hepatocarcinoma and Cholestasis Associated to Germline Hemizygous Deletion of Gene HNF1B
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - April 26, 2019 Category: Gastroenterology Tags: Image of the Month Source Type: research

Ileal Obstruction Secondary to Strangulation of the Ventriculoperitoneal Shunt Catheter
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - April 26, 2019 Category: Gastroenterology Tags: Image of the Month Source Type: research

Palm Oil and Beta-palmitate in Infant Formula: A Position Paper by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Committee on Nutrition
Conclusions: There is insufficient evidence to suggest that PO should be avoided as a source of fat in infant formulas for health reasons. Inclusion of high SN-2-palmitate fat blend in infant formulas may have short-term effects on stool consistency but cannot be considered essential. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - April 26, 2019 Category: Gastroenterology Tags: Society Paper Source Type: research

Docosahexaenoic Acid in Mature Breast Milk of Low-income Mothers
Docosahexaenoic acid (DHA) is among the main components of synaptosomal membranes and myelin sheaths. Because DHA is essential for child neurodevelopment, breast milk DHA levels should be improved by optimizing maternal nutrition. We determined DHA percentage levels in breast milk of low-income mothers receiving care at the public healthcare sector. We performed a descriptive, cross-sectional study in breast milk samples from 39 exclusively breast-feeding adult mothers with normal fetal and neonatal history. Samples were collected 90 ± 7 days after delivery. Breast milk fatty acid composition was determined by g...
Source: Journal of Pediatric Gastroenterology and Nutrition - April 26, 2019 Category: Gastroenterology Tags: Short Communications: Nutrition Source Type: research

Development of Acute Malnutrition Despite Nutritional Supplementation in Malawi
Malnutrition in children is most often attributed to inadequate nutrient intake. Utilizing data from 2 prospective, randomized controlled trials of complimentary feeding with supplemental legumes (n = 693, ages 6–24 months) in 2 Malawian villages, Masenjere, and Limera, we document a high rate 70/693 (10.1%) of acute malnutrition (AM). Risks for AM in this setting, as determined by Cox regression analysis, include study village (hazard ratio [HR] 3.0), prior malnutrition (HR 4.12), stunting (HR 2.87), and a marker of food insecurity (HR 1.89). Comparison of Masenjere to Limera demonstrate adequate and similar nut...
Source: Journal of Pediatric Gastroenterology and Nutrition - April 26, 2019 Category: Gastroenterology Tags: Short Communications: Nutrition Source Type: research

Preterm Birth Has Effects on Gut Colonization in Piglets Within the First 4 Weeks of Life
Conclusions: Preterm and term piglets, born and reared in similar ways, show differences in GM colonization during the first 4 weeks of life, which may play a role for early and later gut dysfunction resulting from preterm birth. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - April 26, 2019 Category: Gastroenterology Tags: Original Article: Nutrition Source Type: research