Protocolized Intervention for Children and Adolescents With Phagophobia
We aimed to prospectively evaluate the effectiveness of a protocolized shaping intervention in children with phagophobia, which occurs when an aversive oral experience causes fear of swallowing and can result in restricted oral intake and weight loss. Twenty-one children (12 males) diagnosed with phagophobia (mean age 8.5 years) underwent initial medical workup and a pediatric psychologist driven shaping protocol. The outpatient protocol involved graduated food exposure with anxiety reduction strategies to eliminate anxiety and expand participants’ diet. The participants completed an average of 6 treatment sessions. Post...
Source: Journal of Pediatric Gastroenterology and Nutrition - November 24, 2022 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Relationship of Functional Constipation and Growth Status: A Systematic Review and Meta-Analysis
Objectives: Functional constipation (FC) and malnutrition are 2 of the most common diseases affecting children worldwide with long-term consequences. We hereby performed a systematic review and meta-analysis to analyze the relationship between these 2 entities. Methods: We searched PubMed, American Academics of Pediatrics (AAP), Cochrane, ClinicalTrials.gov (from inception to December 11, 2021) using “constipation,” “growth,” and “children” as the keywords. Newcastle-Ottawa Scale was used as the risk of bias assessment tool. Meta-analysis using the random-effects model was done. Results: Eight...
Source: Journal of Pediatric Gastroenterology and Nutrition - November 24, 2022 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Intra- and Inter-observer Agreement of High Resolution Antroduodenal Manometry in Pediatric Patients Among Single Center Experts
Conclusions: Our study demonstrated higher diagnostic accuracy for high-resolution ADM compared to the low-resolution recordings. However, although it is well established for other motility investigations, PTP is not yet reliable in assessing foregut motor patterns. Advanced and more sophisticated software are clearly required for analyzing PTP display. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - November 24, 2022 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

The rs12532734 Polymorphism Near the Solute Carrier 26A3 Gene Locus Is Associated With Gallstone Disease in Children
Gallstones are increasingly frequent in children. In this candidate gene study, we genotyped 5 gene variants (ANO1, SPTLC3, TMEM147, TNRC6B, rs12532734) from a recent gallstone genome-wide association study (GWAS) in a cohort of 214 children with gallstones and 172 gallstone-free adult controls. In total, 138 genotyped children presented with symptomatic gallstone disease, 47 underwent cholecystectomy, and 126 received ursodeoxycholic acid (UDCA) as therapy for stones. Among 5 tested variants, the rs12532734 polymorphism modulated the gallstone risk in the studied cohort. Its genotype distribution significantly (P = 0.025)...
Source: Journal of Pediatric Gastroenterology and Nutrition - November 24, 2022 Category: Gastroenterology Tags: Short Communication: Hepatology Source Type: research

Health Care Disparities in Gastroenterology: The Pediatric Gastroenterology Perspective
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - November 24, 2022 Category: Gastroenterology Tags: Invited Commentary Source Type: research

Journal of Pediatric Gastroenterology and Nutrition 2022 Reviewer Acknowledgement
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - November 24, 2022 Category: Gastroenterology Tags: Award Source Type: research

Pediatric Gastrointestinal Bleed: A Novel Vascular Malformation
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - November 1, 2022 Category: Gastroenterology Tags: Images of the Month Source Type: research

Gastric Duplication Cyst
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - November 1, 2022 Category: Gastroenterology Tags: Images of the Month Source Type: research

Outcomes Analyses of Pediatric Acute Liver Failure Subjects Listed for Liver Transplantation: Erratum
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - November 1, 2022 Category: Gastroenterology Tags: Erratum Source Type: research

Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Nutritional Status and Intake in Children
Conclusions: Combined EN and PN providing 115% of BMR and 1.5 g/kg protein ensured stable weight by day +28 and covered RI, except for trace elements and minerals. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - November 1, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

The Role of Manganese in Very Low Birth Weight Infants
Objectives: High manganese (Mn) levels during fetal growth or prolonged parenteral nutrition (PN) may have adverse effects on neurodevelopment. We aim to report on Mn levels and their short-term impact on clinical course in very low birth weight infants. Methods: An observational study including newborns with a gestational age (GA) ≤32 weeks and/or ≤1500 g of birth weight (BW). Newborns received intravenous supplementation of Mn at 1 µg/kg/day (Peditrace®) in PN and continued with fortified breast milk. Mothers answered surveys about dietary and other habits and blood levels of Mn in newborns were analyz...
Source: Journal of Pediatric Gastroenterology and Nutrition - November 1, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Macronutrient and Micronutrient Intake in Adolescents With Non-alcoholic Fatty Liver Disease: The Association With Disease Severity
The objective of this study is to (1) assess the macronutrient and micronutrient intake in adolescents with liver biopsy proven NAFLD [with and without non-alcoholic steatohepatitis (NASH)] and lean controls; (2) determine nutritional predictors of disease severity amongst these groups. Methods: Adolescents with biopsy-proven NAFLD and lean controls completed the Harvard Food Frequency Questionnaire. Results: Twenty-eight NAFLD and 15 lean controls were studied. NAFLD with (n = 20) and without NASH (n = 8) had similar total calorie, protein, fat, and carbohydrate intake. Subjects with NASH had higher total su...
Source: Journal of Pediatric Gastroenterology and Nutrition - November 1, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Effect of Helicobacter pylori Infection on Macromineral and Trace Element Status—Systematic Review and Meta-Analysis
Conclusions: The study demonstrated a lack of evidence of an effect of Hp infection on serum zinc, copper, and calcium status. Studies concerning magnesium, phosphorus, and iodine status are warranted. Furthermore, larger and well-controlled studies are recommended. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - November 1, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Pre-endoscopy Symptoms and Age, But Not Esophageal Biopsy Number Are Associated With Post-endoscopy Adverse Events
Esophagogastroduodenoscopy (EGD) is a frequently utilized investigative tool in the management of gastrointestinal conditions in children. Biopsies obtained during EGD may pose risk for post-operative adverse events (AEs), and further understanding of risk is imperative to provide informed consent to families and safe patient care. In particular, the impact of biopsy number and location on the development of AEs has not been studied in pediatric patients. We prospectively assessed for AEs by telephone survey 3–7 days after 209 EGDs performed on patients ages 1–21 years over a 1-year period. Demographic, endoscopic, and...
Source: Journal of Pediatric Gastroenterology and Nutrition - November 1, 2022 Category: Gastroenterology Tags: Short Communication: Endoscopy and Procedures Source Type: research

Community Perspective on Pancreatic Enzyme Replacement Therapy in Cystic Fibrosis
People with cystic fibrosis (CF) and exocrine pancreatic insufficiency must take pancreatic enzyme replacement therapy (PERT) to prevent malnutrition and gastrointestinal (GI) symptoms. Finding better ways to manage GI complaints is a high priority for the CF community. We fielded a survey to assess the perspective of people affected by CF regarding symptoms attributed to and challenges associated with current PERT, to identify factors that affect participation in PERT studies, and to understand attitudes toward an outcome measure that could be an alternative to the coefficient of fat absorption test. Persistent GI symptom...
Source: Journal of Pediatric Gastroenterology and Nutrition - November 1, 2022 Category: Gastroenterology Tags: Short Communication: Pancreatology Source Type: research