Journal of Pediatric Gastroenterology and Nutrition This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Role of the Urban Exposome in the Increasing Global Rates of Pediatric Inflammatory Bowel Disease
Pediatric inflammatory bowel disease (IBD) is becoming increasingly common around the world, rapidly accelerating in regions undergoing rapid economic development. IBD is more common among those living in cities, and the association between the urban environment and IBD incidence is strongest in children. The “urban exposome” is defined as the totality of environmental exposures associated with urban living: air pollution, water contamination, green and blue space, nighttime light, noise, and availability of pre-processed and packaged foods. Investigation of the role of the urban exposome and IBD is in its infancy. Exi...
Source: Journal of Pediatric Gastroenterology and Nutrition - July 28, 2022 Category: Gastroenterology Tags: Topic of the Month Source Type: research

Managing the Impact of Cronobacter sakazakii, the Nemesis of Powdered Formula
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - July 28, 2022 Category: Gastroenterology Tags: Invited Commentary Source Type: research

Pumpkin Man
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2022 Category: Gastroenterology Tags: Image of the Month Source Type: research

Late Diagnosis of a Congenital Diaphragmatic Defect With a Large Enterothorax in a 7-Year-Old-Child
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2022 Category: Gastroenterology Tags: Image of the Month Source Type: research

Stir, Shake or Blend: A Comparison of Methods Used to Reduce Viscosity of Blenderized Tube Feedings
This study compared changes in viscosity of commercially available BTF s when stirred, shaken, or blenderized. The International Dysphagia Diet Standardisation Initiative flow test was used to provide an objective level of viscosity. Our results indicate that the method chosen to thin BTFs results in significant differences in viscosity and varies depending on the percent of water by volume added to the formula as well as the presence of additional non-food ingredients such as synthetic supplements. We conclude that the method used to thin BTFs should be taken into account when a consistent viscosity level is desired. (Sou...
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2022 Category: Gastroenterology Tags: Short Communication: Nutrition Source Type: research

Outcomes of the First 54 Pediatric Patients on Long-Term Home Parenteral Nutrition from a Single Brazilian Center
Conclusion: The treatment of pediatric patients with IF followed by a multidisciplinary pediatric intestinal rehabilitation program with HPN is feasible and safe in the Brazilian public health system. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Impact of Surfactant Protein-A on Immunomodulatory Properties of Murine and Human Breast Milk
Conclusions: SP-A is present in human and murine milk and plays a role in lowering inflammation in murine pup terminal ileum. Both baseline inflammation and induced inflammatory responses are reduced via exposure to SP-A in milk with the effect amplified in inflammatory conditions. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Insight Into the Adolescent Patient Experience With Nonalcoholic Fatty Liver Disease
Conclusions: Adolescents with NAFLD may benefit from personalized treatment. Care could be enhanced by ensuring comprehension of diagnosis, problem-solving personal, and family barriers and increasing family support. Harnessing adolescents’ desire for weight loss may be a more salient driver for change in disease status. Interventions should also address systemic barriers such as food insecurity to ensure equitable care. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2022 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Presentation, Management, and Outcome of Congenital Portosystemic Shunts in Children: The Boston Children’s Hospital Experience
We describe presentations, complications, associations, and outcomes of CPSS at Boston Children’s Hospital (BCH). Methods: This was a retrospective review of children with CPSS at BCH from 2000 to 2020. Results: Twenty-nine patients had CPSS (17 girls): 14 extrahepatic (EH) and 15 intrahepatic (IH). At diagnosis, 15 were ≤5 days, 7 1 year (range 1–19). Median follow-up duration was 5.2 years (interquartile range [IQR] 1.6–10.9) in EH and 2.2 years (0.2–4.2) in IH CPSS. The most common presentation was antenatal ultrasound 13 (45%) followed by hyperammonemia 10 (34%), whereas 6 (21%) were asymptomati...
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2022 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Differences in Clinical Presentation of Eosinophilic Esophagitis in Pediatric Patients With Ulcerative Colitis and Crohn Disease
Conclusion: A higher percentage of UC than CD patients had EoE. EoE was more likely to be present at the initial diagnosis of UC than CD. EoE was more likely after diagnosis and treatment of CD with anti-TNF, when CD activity was mild or in remission. The difference in presentation suggests that anti-TNF or it’s impact on inflammation may differentially impact the association of EoE with CD and UC. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2022 Category: Gastroenterology Tags: Original Article: Gastroenterology: Eosinophilic Gastrointestinal Disease Source Type: research

6- and 12-Month Outcomes after 90:10 Enteral Nutrition Induction Therapy in Pediatric Crohn’s Disease
Conclusions: In this retrospective study of short and longer-term outcomes after 90:10 EN induction, the need for an alternate induction therapy was common, most frequently to anti-TNF or corticosteroid therapy. Future studies are needed to evaluate for predictors of long-term success after EN induction. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2022 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Utilization of Antitumor Necrosis Factor Biologics in Very Early Onset Inflammatory Bowel Disease: A Multicenter Retrospective Cohort Study From North America
Background: Research on the utilization and effectiveness of antitumor necrosis factor (TNF) biologics in children with very early onset inflammatory bowel disease (VEOIBD) is urgently needed. Here we describe anti-TNF use and durability in a multicenter cohort. Methods: We performed a retrospective cohort study of patients diagnosed with VEOIBD ( (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2022 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Patient and Caregivers’ Perspectives on Biosimilar Use in Pediatric Inflammatory Bowel Disease
The objective of this study was to evaluate the perspectives of pediatric patients with IBD and their caregivers regarding biosimilar use and non-medical switches. Methods: A survey was given to a cross section of patients with IBD ages 11–21 years receiving the intravenous anti-tumor necrosis factor originator and caregivers of patients with IBD ages 3–21 years receiving the originator. Recruitment occurred via mail, during clinic visits, and infusions. Fisher exact tests were used to test for statistically significant differences. Results: Response rate amongst caregivers was 49% (n = 98) and among pati...
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2022 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

FOCAD Indel in a Family With Juvenile Polyposis Syndrome
Juvenile polyposis syndrome (JPS) is a childhood polyposis syndrome with up to a 50% lifetime risk of gastrointestinal cancer. Germline pathogenic variants in BMPR1A and SMAD4 are responsible for around 40% of cases of JPS, but for the majority of individuals, the underlying genetic cause is unknown. We identified a family for which polyposis spanned four generations, and the proband had a clinical diagnosis of JPS. Next-generation sequencing was conducted, followed by Sanger sequencing confirmation. We identified an internal deletion of the FOCAD gene in all family members tested that altered the reading frame and is pred...
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2022 Category: Gastroenterology Tags: Short Communications: Gastroenterology Source Type: research

Utilization of Pediatric Psychology Services in Outpatient Pediatric Gastroenterology Within a Rural Health System
Increased utilization of pediatric psychology services has been demonstrated following integration into urban pediatric gastroenterology clinics; however, examination within rural health systems is lacking. Utilization of pediatric psychology services was assessed through a retrospective analysis of Electronic Health Record data contrasting referrals occurring six months pre- and post-integration of pediatric psychology in an outpatient pediatric gastroenterology clinic within a rural setting. Significant increases in the number of referrals to pediatric psychology and number of billed initial visits were observed after in...
Source: Journal of Pediatric Gastroenterology and Nutrition - July 1, 2022 Category: Gastroenterology Tags: Short Communications: Gastroenterology Source Type: research