The Role of Surgical Management in Chronic Pancreatitis in Children: A Position Paper From the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Pancreas Committee
Conclusions: The morphology of disease and the presence of genetic risk factors must be considered while determining the optimal surgical approach for children with CP. Surgical outcomes for CP are variable and depend on the type of intervention. A multidisciplinary team approach is needed to assure that the best possible operation is selected for each patient, their recovery is optimized, and their immediate and long-term postoperative needs are well-met. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Society Papers Source Type: research

A Practical Approach to Identifying Pediatric Disease-Associated Undernutrition: A Position Statement from the ESPGHAN Special Interest Group on Clinical Malnutrition
Disease-associated undernutrition (DAU) is still common in hospitalized children and is generally accepted to be associated with adverse effects on disease outcomes; hence making proper identification and assessment essential in the management of the sick child. There are however several barriers to routine screening, assessment, and treatment of sick children with poor nutritional status or DAU, including limited resources, lack of nutritional awareness, and lack of agreed nutrition policies. We recommend all pediatric facilities to 1) implement procedures for identification of children with (risk of) DAU, including nutri...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Society Papers Source Type: research

Colonic Function Investigations in Children: Review by the ESPGHAN Motility Working Group
Disorders of colonic motility, most often presenting as constipation, comprise one of the commonest causes of outpatient visits in pediatric gastroenterology. This review, discussed and created by the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Motility Working Group, is a practical guide, which highlights the recent advances in pediatric colonic motility testing including indications, technical principles of the tests, patient preparation, performance and basis of the results’ analysis of the tests. classical methods, such as colonic transit time (cTT) with radiopaque markers and ...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Society Papers Source Type: research

Anaemia in Children Receiving Home Parenteral Nutrition: A Common Problem?
Conclusions: Iron deficiency anaemia is common in children receiving HPN. A large proportion of patients still receive blood transfusions as first-line therapy but intravenous iron can be a suitable alternative. Treatment guidelines are required. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Five-Year Inpatient Management of Teenagers With Anorexia Nervosa: Focus on Nutritional Issues
Objectives: In patients with Anorexia Nervosa (AN) malnutrition can lead to life-long nutritional treatments. The refeeding process can combine natural feeding (NF) with specific nutritional strategies, including oral nutritional supplements (ONS) and nasogastric feeding (NGF). Aims of the present study were to assess the efficacy of hospital protocol and identify the most effective inpatient nutritional strategies for weight restoration. Methods: All patients hospitalized from April 2015 to April 2020 were enrolled. According to hospital protocol, NF was proposed to all patients; ONS were combined with NF if ca...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Nutritional and Safety Concerns of Infant Feeding Trends
Conclusion: The AAP has clear guidelines on infant nutrition and breastfeeding and when not possible, FDA reviewed infant formula or donor breast milk from an established milk bank as alternatives. Yet, our study found that at least 18% of the families across the united States were following at least one contemporary feeding practice with possible nutritional and safety concerns. it is important for pediatric gastroenterologists and dieticians to ask their patients how they are feeding their infants and be aware of these feeding practices that may pose significant health risks. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Training in Paediatric Clinical Nutrition Across Europe: A Survey of the National Societies Network (2016–2019) of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition
Objectives/Background: Disease-related malnutrition is common in patients with chronic diseases and has detrimental effects, therefore, skills in nutrition care are essential core competencies for paediatric digestive medicine. The aim of this survey, conducted as part of a global survey of paediatric gastroenterology, hepatology and nutrition (PGHN) training in Europe, was to assess nutrition care-related infrastructure, staff, and patient volumes in European PGHN training centres. Methods: Standardized questionnaires related to clinical nutrition (CN) care were completed by representatives of European PGHN tra...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Landscape of Pediatric Endoscopic Ultrasound in a United States Tertiary Care Medical Center
Conclusion: The diagnostic and therapeutic role for EUS in adults has expanded dramatically, however the role of EUS in pediatrics is not well-defined. In this, the largest pediatric EUS study to date, our data support the safety and utility of diagnostic and therapeutic EUS in pediatrics. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Original Articles: Endoscopy and Procedures Source Type: research

Colonoscope “Looping” During Ileo-Colonoscopy in Children is Significantly Different to that Observed in Adult Practice
Conclusions: This study represents the first attempt to describe loop formation according to patient characteristics in a large paediatric series. Further studies are needed in order to establish if these findings could be helpful in simplifying the execution of IC procedures in children and facilitate the learning curve during endoscopy training programs. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Original Articles: Endoscopy and Procedures Source Type: research

A Model for Early Endoscopic Detection of High-Risk Gastroesophageal Varices in Children With Biliary Atresia
Conclusion: The results suggest that the model reported may be a useful tool for the early detection of HRVs to allow primary prophylaxis of bleeding. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Original Articles: Endoscopy and Procedures Source Type: research

Health-Related Quality of Life in Pediatric Acute Recurrent or Chronic Pancreatitis: Association With Biopsychosocial Risk Factors
Objectives: Abdominal pain, emergency department visits, and hospitalizations impact lives of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Data on health-related quality of life (HRQOL) in this population, however, remains limited. We aimed to evaluate HRQOL in children with ARP or CP; and test biopsychosocial risk factors associated with low HRQOL. Methods: Data were acquired from the INternational Study Group of Pediatric Pancreatitis: In search for a cuRE registry. Baseline demographic and clinical questionnaires, the Child Health Questionnaire (measures HRQOL) and Child Beh...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Original Article: Pancreatology Source Type: research

Severe Hepatitis in Pediatric Coronavirus Disease 2019
We report a case series of four previously healthy children who presented with significant hepatitis as the primary manifestation of COVID-19 infection. Two of these patients met criteria for acute liver failure. None of the patients had respiratory symptoms. One patient was found to have complement dysfunction resulting in microangiopathic features and was treated successfully with eculizumab. This case is in line with adult post-mortem data showing that more severe cases of hepatic dysfunction secondary to COVID-19 infection may be associated with complement activation and microangiopathic features. Liver function should...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Short Communication: Hepatology Source Type: research

Ledipasvir-sofosbuvir in Adolescents With Chronic Hepatitis C and Hematological Malignancies Undergoing Chemotherapy
Conclusions: Ledipasvir-sofosbuvir was well-tolerated and efficacious in adolescents with chronic HCV genotype 4 and leukemia undergoing maintenance chemotherapy. These data support the use of this interferon and ribavirin-free regimen in adolescents with hematological malignancies. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

MYO5B Gene Mutations: A Not Negligible Cause of Intrahepatic Cholestasis of Infancy With Normal Gamma-Glutamyl Transferase Phenotype
Conclusions: We identified causative mutations in MYO5B in 18.7% of a selected cohort of patients with intrahepatic cholestasis confirming a relevant role for the MYO5B gene in low-GGT cholestasis. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Esophageal Microbiome in Healthy Children and Esophageal Eosinophilia
Conclusions: The pediatric esophagus has an abundant and diverse microbiome, both in the healthy and diseased states. The healthy group had a higher, but not significantly different, diversity and richness index compared to other groups. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - May 1, 2022 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Eosinophilic Gastrointestinal Disease Source Type: research