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Efficacy and safety of rituximab in myelin oligodendrocyte glycoprotein antibody-associated disorders compared with neuromyelitis optica spectrum disorder: a systematic review and meta-analysis
Conclusions RTX showed effective in MOGAD, although to a lesser extent than in AQP4-IgG+NMOSD, while the safety profile warrants some caution in its prescription. Randomised-controlled trials are needed to confirm these findings and provide robust evidence to improve treatment strategies in patients with MOGAD. PROSPERO registration number CRD42020175439. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2022 Category: Neurosurgery Authors: Spagni, G., Sun, B., Monte, G., Sechi, E., Iorio, R., Evoli, A., Damato, V. Tags: Neuro-inflammation Source Type: research

Association of obesity with disease outcome in multiple sclerosis
Conclusions Obesity in newly diagnosed patients with MS is associated with higher disease severity and poorer outcome. Obesity management could improve clinical outcome of MS. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2022 Category: Neurosurgery Authors: Lutfullin, I., Eveslage, M., Bittner, S., Antony, G., Flaskamp, M., Luessi, F., Salmen, A., Gisevius, B., Klotz, L., Korsukewitz, C., Berthele, A., Groppa, S., Then Bergh, F., Wildemann, B., Bayas, A., Tumani, H., Meuth, S. G., Trebst, C., Zettl, U. K., P Tags: Open access, Press releases Neuro-inflammation Source Type: research

Short-lasting unilateral neuralgiform headache attacks (SUNCT/SUNA): a narrative review of interventional therapies
Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache with autonomic symptoms (SUNA) are disabling primary headache disorders. The advent of advanced imaging technologies and surgical techniques has translated to a growing arsenal of interventional therapies capable of treating headache disorders. This literature review sheds light on the current evidence available for interventional therapies in medically intractable SUNCT/SUNA. PubMed and EMBASE were searched for publications between 1978 and 2022. Inclusion criteria were ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2022 Category: Neurosurgery Authors: Smit, R. D., Mouchtouris, N., Kang, K., Reyes, M., Sathe, A., Collopy, S., Prashant, G., Yuan, H., Evans, J. J. Tags: Neurosurgery Source Type: research

Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial
Conclusion The efficacy of LEV was similar to that of FPHT for adult SE following the administration of diazepam. LEV may be recommended as a second-line treatment for SE along with phenytoin/FPHT. Trial registration number jRCTs031190160. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2022 Category: Neurosurgery Authors: Nakamura, K., Marushima, A., Takahashi, Y., Mochizuki, M., Kimura, A., Fukuda, Y., Asami, M., Nakamoto, H., Egawa, S., Kaneko, J., Unemoto, K., Kondo, Y., Yonekawa, C., Uchida, M., Hoshiyama, E., Yamada, T., Maruo, K., Ishikawa, E., Matsumaru, Y., Inoue, Tags: Open access Epilepsy Source Type: research

Safety of breast feeding during rituximab treatment in multiple sclerosis
Conclusions We found minimal transfer of rituximab into breast milk and could not reliably detect levels of rituximab in infant serum. B cell counts in infants were unaffected. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2022 Category: Neurosurgery Authors: Rod, B. E., Torkildsen, O., Myhr, K.-M., Bo, L., Wergeland, S. Tags: JNNP Patients' choice, Open access Multiple sclerosis Source Type: research

Brain age gap in neuromyelitis optica spectrum disorders and multiple sclerosis
Conclusions There is a clear BAG in NMOSD, although smaller than in RRMS. The BAG is a clinically relevant MRI marker in NMOSD and RRMS. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2022 Category: Neurosurgery Authors: Wei, R., Xu, X., Duan, Y., Zhang, N., Sun, J., Li, H., Li, Y., Li, Y., Zeng, C., Han, X., Zhou, F., Huang, M., Li, R., Zhuo, Z., Barkhof, F., H Cole, J., Liu, Y. Tags: Multiple sclerosis Source Type: research

Heterogeneity on long-term disability trajectories in patients with secondary progressive MS: a latent class analysis from Big MS Data network
Conclusions Contrary to previous interpretations, patients with SPMS progress at greatly different rates. Our identification of distinct trajectories can guide better patient selection in future phase 3 SPMS clinical trials. Additionally, distinct trajectories could reflect heterogeneous pathological mechanisms of progression. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2022 Category: Neurosurgery Authors: Signori, A., Lorscheider, J., Vukusic, S., Trojano, M., Iaffaldano, P., Hillert, J., Hyde, R., Pellegrini, F., Magyari, M., Koch-Henriksen, N., Sorensen, P. S., Spelman, T., van der Walt, A., Horakova, D., Havrdova, E., Girard, M., Eichau, S., Grand'Maiso Tags: Multiple sclerosis Source Type: research

Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations
Conclusions Patients treated with fingolimod or rituximab should be informed about the risk of reduced humoral immunity and vaccinations should be timed carefully in rituximab patients. Our results identify the need for studies regarding the durability of vaccine responses, the role of cellular immunity and revaccinations. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2022 Category: Neurosurgery Authors: König, M., Lorentzen, A. R., Torgauten, H. M., Tran, T. T., Schikora-Rustad, S., Vaage, E. B., Mygland, A., Wergeland, S., Aarseth, J., Aaberge, I. A. S., Torkildsen, O., Holmoy, T., Berge, T., Myhr, K.-M., Harbo, H. F., Andersen, J. T., Munthe, L Tags: Open access, COVID-19 Multiple sclerosis Source Type: research

Spinal cord lesions and brain grey matter atrophy independently predict clinical worsening in definite multiple sclerosis: a 5-year, multicentre study
Conclusions Spinal cord damage and, to a lesser extent, cortical volume loss helped predicting worse 5-year clinical outcomes in MS. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2022 Category: Neurosurgery Authors: Rocca, M. A., Valsasina, P., Meani, A., Gobbi, C., Zecca, C., Barkhof, F., Schoonheim, M. M., Strijbis, E. M., Vrenken, H., Gallo, A., Bisecco, A., Ciccarelli, O., Yiannakas, M., Rovira, A., Sastre-Garriga, J., Palace, J., Matthews, L., Gass, A., Eisele, Tags: Multiple sclerosis Source Type: research

Characterisation of the safety profile of evobrutinib in over 1000 patients from phase II clinical trials in multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus: an integrated safety analysis
Conclusions This is the first BTKi-integrated safety analysis that includes patients with MS. Overall, evobrutinib treatment (all doses) was generally well tolerated across indications. Trial registration numbers NCT02975349, NCT03233230, NCT02975336. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2022 Category: Neurosurgery Authors: Montalban, X., Wallace, D., Genovese, M. C., Tomic, D., Parsons-Rich, D., Le Bolay, C., Kao, A. H., Guehring, H. Tags: Open access Multiple sclerosis Source Type: research

Brain neuronal and glial damage during acute COVID-19 infection in absence of clinical neurological manifestations
Conclusion The results of our study suggest that neuronal and glial degeneration can occur in patients with COVID-19 regardless of overt clinical neurological manifestations. With age, levels of sNfl and GFAp can predict in-hospital COVID-19-associated mortality and might be useful to assess COVID-19 patient prognostic profile. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2022 Category: Neurosurgery Authors: Plantone, D., Locci, S., Bergantini, L., Manco, C., Cortese, R., Meocci, M., Cavallaro, D., d'Alessandro, M., Bargagli, E., De Stefano, N. Tags: COVID-19 Neuro-inflammation Source Type: research

Can brain signals and anatomy refine contact choice for deep brain stimulation in Parkinsons disease?
Conclusion This work supports the development of probability-based algorithms using neuronal signals and anatomical data to assist programming of deep brain stimulation. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2022 Category: Neurosurgery Authors: Xu, S. S., Lee, W.-L., Perera, T., Sinclair, N. C., Bulluss, K. J., McDermott, H. J., Thevathasan, W. Tags: Movement disorders Source Type: research

Comparing switch to ocrelizumab, cladribine or natalizumab after fingolimod treatment cessation in multiple sclerosis
Conclusion After fingolimod cessation, ocrelizumab and natalizumab were more effective in reducing relapses than cladribine. Due to the low ARRs in all three treatment groups, additional observation time is required to determine if statistical difference in ARRs results in long-term disability differences. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2022 Category: Neurosurgery Authors: Zhu, C., Zhou, Z., Roos, I., Merlo, D., Kalincik, T., Ozakbas,, S., Skibina, O., Kuhle, J., Hodgkinson, S., Boz, C., Alroughani, R., Lechner-Scott, J., Barnett, M., Izquierdo, G., Prat, A., Horakova, D., Kubala Havrdova, E., Macdonell, R., Patti, F., Khou Tags: Multiple sclerosis Source Type: research

Early predictors of disability in paediatric multiple sclerosis: evidence from a multi-national registry
Conclusions A relatively later onset of MS in childhood, higher disability and pyramidal, visual or cerebellar symptoms during the first year predicted significant worsening in disability in patients with paediatric-onset MS. Persistent treatment with higher-efficacy DMTs was associated with a reduced rate of disability worsening. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2022 Category: Neurosurgery Authors: Sharmin, S., Malpas, C. B., Roos, I., Diouf, I., Alroughani, R., Ozakbas, S., Izquierdo, G., Eichau, S., Horakova, D., Havrdova, E. K., Patti, F., Terzi, M., Boz, C., Yamout, B., Khoury, S. J., Onofrj, M., Lugaresi, A., Altintas, A., Prat, A., Girard, M., Tags: Multiple sclerosis Source Type: research

Rebound of clinical disease activity after fingolimod discontinuation? A nationwide cohort study of patients in Denmark
Conclusions Based on average ARR levels, there was no evidence of clinical rebound after fingolimod discontinuation. In total, 12.5% of patients had clinical rebound. Only 3.6%, however, had clinical rebound without disease activity before discontinuation. Disease activity before discontinuation, female sex and younger age were statistically significantly associated with a higher relapse risk after discontinuation. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2022 Category: Neurosurgery Authors: Framke, E., Pontieri, L., Bramow, S., Sellebjerg, F., Magyari, M. Tags: Multiple sclerosis Source Type: research