Heterogeneity on long-term disability trajectories in patients with secondary progressive MS: a latent class analysis from Big MS Data network

Conclusions Contrary to previous interpretations, patients with SPMS progress at greatly different rates. Our identification of distinct trajectories can guide better patient selection in future phase 3 SPMS clinical trials. Additionally, distinct trajectories could reflect heterogeneous pathological mechanisms of progression.

http://jnnp.bmj.com/cgi/content/short/94/1/23?rss=1

Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2022 Category: Neurosurgery Authors: Signori, A., Lorscheider, J., Vukusic, S., Trojano, M., Iaffaldano, P., Hillert, J., Hyde, R., Pellegrini, F., Magyari, M., Koch-Henriksen, N., Sorensen, P. S., Spelman, T., van der Walt, A., Horakova, D., Havrdova, E., Girard, M., Eichau, S., Grand'Maiso Tags: Multiple sclerosis Source Type: research