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Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy
Conclusions Epileptiform and spectral characteristics enhance covariates identified on TBI admission and CT abnormalities in PTE1 prediction. Future trials should incorporate quantitative electroencephalography features to validate this enhancement of PTE risk stratification models. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2023 Category: Neurosurgery Authors: Chen, Y., Li, S., Ge, W., Jing, J., Chen, H. Y., Doherty, D., Herman, A., Kaleem, S., Ding, K., Osman, G., Swisher, C. B., Smith, C., Maciel, C. B., Alkhachroum, A., Lee, J. W., Dhakar, M. B., Gilmore, E. J., Sivaraju, A., Hirsch, L. J., Omay, S. B., Blum Tags: Epilepsy Source Type: research

STN-DBS electrode placement accuracy and motor improvement in Parkinsons disease: systematic review and individual patient meta-analysis
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective neurosurgical treatment for Parkinson’s disease. Surgical accuracy is a critical determinant to achieve an adequate DBS effect on motor performance. A two-millimetre surgical accuracy is commonly accepted, but scientific evidence is lacking. A systematic review and meta-analysis of study-level and individual patient data (IPD) was performed by a comprehensive search in MEDLINE, EMBASE and Cochrane Library. Primary outcome measures were (1) radial error between the implanted electrode and target; (2) DBS motor improvement on the Unified Park...
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2023 Category: Neurosurgery Authors: Kremer, N. I., van Laar, T., Lange, S. F., Statius Muller, S., la Bastide-van Gemert, S., Oterdoom, D. M., Drost, G., van Dijk, J. M. C. Tags: Movement disorders Source Type: research

Can quantitative susceptibility mapping help diagnose and predict recovery of concussion in children? An A-CAP study
Conclusion The findings suggest that QSM is a potential MRI biomarker that can help predict PPCS in children with concussion, over and above the current clinical benchmark, and thereby aid in clinical management. They also suggest a frontal lobe substrate for PPCS, highlighting the potential for QSM to clarify the neurophysiology of paediatric concussion. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2023 Category: Neurosurgery Authors: Sader, N., Gobbi, D., Goodyear, B., Frayne, R., Ware, A. L., Beauchamp, M. H., Craig, W. R., Doan, Q., Zemek, R., Riva-Cambrin, J., Yeates, K. O., On behalf of the Pediatric Emergency Research Canada A-CAP study team Tags: Neurosurgery Source Type: research

Trends and inequities in the diagnosis and treatment of poststroke depression: a retrospective cohort study of privately insured patients in the USA, 2003-2020
Conclusions In this insured population, we identify potential inequities in clinical management of poststroke depression by gender, race/ethnicity and age that may reflect barriers other than access to healthcare. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2023 Category: Neurosurgery Authors: Elser, H., Caunca, M., Rehkopf, D. H., Andres, W., Gottesman, R. F., Kasner, S. E., Yaffe, K., Schneider, A. L. C. Tags: JNNP Patients' choice Cerebrovascular disease Source Type: research

CSF ferritin in the clinicopathological progression of Alzheimers disease and associations with APOE and inflammation biomarkers
Conclusions CSF markers of iron and neuroinflammation have distinct associations with disease stages, while iron may be more intimately associated with apolipoprotein E and tau pathology. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2023 Category: Neurosurgery Authors: Ayton, S., Janelidze, S., Kalinowski, P., Palmqvist, S., Belaidi, A. A., Stomrud, E., Roberts, A., Roberts, B., Hansson, O., Bush, A. I. Tags: Editor's choice Cognition Source Type: research

Prognostic relevance of quantitative and longitudinal MOG antibody testing in patients with MOGAD: a multicentre retrospective study
Conclusions Persistent MOG-IgG positivity and high remission titres are associated with an increased relapse risk. Longitudinal MOG-IgG titres could be useful to stratify patients to be treated with long term immunosuppression. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2023 Category: Neurosurgery Authors: Gastaldi, M., Foiadelli, T., Greco, G., Scaranzin, S., Rigoni, E., Masciocchi, S., Ferrari, S., Mancinelli, C., Brambilla, L., Mancardi, M., Giacomini, T., Ferraro, D., Della Corte, M., Gallo, A., Di Filippo, M., Benedetti, L., Novi, G., Versino, M., Banf Tags: Neuro-inflammation Source Type: research

Motor cortex functional connectivity is associated with underlying neurochemistry in ALS
Conclusion In vivo neurochemistry may represent an effective imaging marker of impaired motor cortex functional connectivity in ALS. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2023 Category: Neurosurgery Authors: Dey, A., Luk, C. C., Ishaque, A., Ta, D., Srivastava, O., Krebs, D., Seres, P., Hanstock, C., Beaulieu, C., Korngut, L., Frayne, R., Zinman, L., Graham, S., Genge, A., Briemberg, H., Kalra, S., for the Canadian ALS Neuroimaging Consortium (CALSNIC) Tags: Open access Neurodegeneration Source Type: research

MRI lesions can often precede trigeminal neuralgia symptoms by years in multiple sclerosis
Conclusions TN lesions can be present years prior to symptom onset, suggestive of alternative explanations than typical relapses. This phenomenon may hint at alternative pathophysiology of progressive MS in comparison to relapsing-remitting MS. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2023 Category: Neurosurgery Authors: Dilwali, S., Mark, I., Waubant, E. Tags: Multiple sclerosis Source Type: research

Choroid plexus enlargement in paediatric multiple sclerosis: clinical relevance and effect of sex
Conclusions CP enlargement occurs in paediatric MS, suggesting its early involvement in the pathophysiology of the disease. The higher CP volume, which is found especially in female patients, supports the hypothesis of sex-related differences occurring already in paediatric MS. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2023 Category: Neurosurgery Authors: Margoni, M., Gueye, M., Meani, A., Pagani, E., Moiola, L., Preziosa, P., Filippi, M., Rocca, M. A. Tags: Multiple sclerosis Source Type: research

Increased cytomegalovirus immune responses at disease onset are protective in the long-term prognosis of patients with multiple sclerosis
Conclusions These results indicate that elevated immune responses against HCMV at disease onset have protective effects on long-term disability and inflammation disease outcomes. Our data also indicate that increased immune responses against EBV in early phases may influence long-term disease prognosis. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2023 Category: Neurosurgery Authors: Comabella, M., Tintore, M., Sao Aviles, A., Carbonell-Mirabent, P., Malhotra, S., Rovira, A., Fissolo, N., Lünemann, J. D., Montalban, X. Tags: Multiple sclerosis Source Type: research

Validation of MATCH score: a predictive tool for identification of patients with kelch-like protein-11 autoantibodies
Introduction Kelch-like protein 11 (KLHL11)-IgG is a high-risk paraneoplastic antibody associated with rhombencephalitis.1–3 Since its initial description, the clinical spectrum associated with KLHL11-IgG paraneoplastic autoimmunity has widened.2 However, some core neurological features are present in the majority of KLHL11-IgG seropositive cases. Using some of these core features, Vogrig et al proposed a MATCH score, which can be used to identify patients harbouring KLHL11-IgG.4 The MATCH score is composed of five elements: M (male sex, 1 point), A (ataxia or other cerebellar signs, 1 point), T and C (testicular tum...
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 11, 2023 Category: Neurosurgery Authors: Hammami, M. B., Rezk, M., Dubey, D. Tags: PostScript Source Type: research

Q351R MAPT mutation is associated with a mixed 3R/4R tauopathy and a slowly progressive cognitive, behavioural and parkinsonian syndrome
Introduction We have previously reported the initial clinical and imaging findings of a woman with a novel MAPT Q351R mutation.1 2 We continued to assess her following these case reports until she died and have now analysed her brain at postmortem. Her case was of unique interest due to the novelty of the mutation and its clinical features1 as well as the strong binding seen on flortaucipir positron emission tomography (PET) imaging,2 which was suggestive of a very specific pathological finding, that of a mixed 3R/4R tauopathy, similar to that seen in other MAPT mutations (V337M and R406W),3 4 and consistent with the same ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 11, 2023 Category: Neurosurgery Authors: Drazich-Taylor, E. H. S., Todd, E., Convery, R., Bocchetta, M., Clarke, M., Warren, J. D., Fox, N. C., Revesz, T., Rohrer, J. D. Tags: PostScript Source Type: research

Prescription opioid use in multiple sclerosis
Introduction Pain can be one of the worst symptoms of multiple sclerosis (MS).1 Modifiable factors, including depression and anxiety, may influence its severity and impact.2 Opioids used for chronic non-cancer pain may be prescribed to persons with MS when neuropathic pain therapies are ineffective. Given the potential harms of opioid use and limited data supporting their utility in MS, it is important to understand the extent of opioid prescribing for persons with MS. We estimated incidence, prevalence and patterns of opioid prescription in an MS population and a matched cohort without MS. We assessed whether comorbid moo...
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 11, 2023 Category: Neurosurgery Authors: Marrie, R. A., Fisk, J. D., Walld, R., Bolton, J. M., Sareen, J., Patten, S. B., Singer, A., Lix, L. M., Hitchon, C. A., El-Gabalawy, R., Katz, A., Marriott, J. J., Bernstein, C. N. Tags: PostScript Source Type: research

Postural misperception: a biomarker for persistent postural perceptual dizziness
Introduction Persistent postural perceptual dizziness (PPPD) describes a persistent sensation of dizziness and/or unsteadiness (without vertigo) aggravated by upright posture that generates increased postural sway.1 Here, we introduce a novel measure of perceived instability to investigate the relationship between observed sway and perceived instability in patients with PPPD compared with patients with persistent ‘objective’ instability due to bilateral vestibulopathy (BV). MethodsParticipants Overall, 19 individuals with PPPD, according to the diagnostic criteria of the International Classification of Vestibul...
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 11, 2023 Category: Neurosurgery Authors: San Pedro Murillo, E., Bancroft, M. J., Koohi, N., Castro, P., Kaski, D. Tags: PostScript Source Type: research

Reliable virtual clinical assessment in spino-bulbar muscular atrophy (SBMA)
Conclusions Our data show that telehealth is a valid tool to monitor patients with SBMA: AMAT and SBMA-FRS scales can be effectively, reliably and easily administered remotely. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 11, 2023 Category: Neurosurgery Authors: Fenu, S., Tramacere, I., De Giorgi, F., Pareyson, D. Tags: COVID-19 Neuromuscular Source Type: research