Journal of Neurology, Neurosurgery and Psychiatry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures
Conclusions The presence of gene–environment interactions with household toxins supports their possible causal role in paediatric-onset multiple sclerosis. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 14, 2023 Category: Neurosurgery Authors: Nasr, Z., Schoeps, V. A., Ziaei, A., Virupakshaiah, A., Adams, C., Casper, T. C., Waltz, M., Rose, J., Rodriguez, M., Tillema, J.-M., Chitnis, T., Graves, J. S., Benson, L., Rensel, M., Krupp, L., Waldman, A. T., Weinstock-Guttman, B., Lotze, T., Greenber Tags: Multiple sclerosis Source Type: research

Multiple sclerosis mortality in New Zealand: a nationwide prospective study
Conclusions New Zealanders with MS have a median survival age 7.2 years lower than the general population and twice the mortality risk. The survival gap was greater for progressive-onset disease and for those with an early age of onset. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 14, 2023 Category: Neurosurgery Authors: Leadbetter, R., MacAskill, M., Myall, D. J., Taylor, B. V., Joshi, P., NZMSPS group, Mason, D. F., Pearson, Clarke, Abernethy, Willoughby, Sabel Tags: JNNP Patients' choice Multiple sclerosis Source Type: research

Spinal cord reserve in multiple sclerosis
Conclusions A larger SCaA may be protective against disability in MS, possibly supporting the existence of SC reserve. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 14, 2023 Category: Neurosurgery Authors: Sastre-Garriga, J., Rovira, A., Garcia-Vidal, A., Carbonell-Mirabent, P., Alberich, M., Vidal-Jordana, A., Auger, C., Tintore, M., Montalban, X., Pareto, D. Tags: Multiple sclerosis Source Type: research

Immersive medical virtual reality: still a novelty or already a necessity?
Virtual reality (VR) technologies have been explored for medical applications for over half a century. With major tech companies such as Meta (formerly Facebook), HTC and Microsoft investing heavily in the development of VR technologies, significant advancements have recently been made in hardware (eg, standalone headsets), ease of use (eg, gesture tracking) and equipment cost. These advancements helped spur research in the medical field, with over 2700 VR-related articles indexed in PubMed alone in 2022, and the number of VR articles more than tripling in the last 6 years. Recently, the US Food and Drug Administration (FD...
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 14, 2023 Category: Neurosurgery Authors: Loetscher, T., Barrett, A. M., Billinghurst, M., Lange, B. Tags: Editorial Source Type: research

Evidence of a third branch in the uncinate fasciculus and possible implications
The uncinate fasciculus (UF) is a ventral, anterior, associative C-shaped white matter bundle that connects the temporo-amygdala-orbitofrontal network, which is functionally dedicated to the integration of visceral and emotional states, cognition and behaviour.1 Issues in that network are shown with cognitive and behavioural symptoms characteristic of temporal lobe epilepsy, mood disorders and neurodegenerative dementias, including Alzheimer’s disease and semantic dementia. In animal studies, the disconnection of the UF causes impairment of object–reward association and learning temporally complex visual inform...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 15, 2023 Category: Neurosurgery Authors: di Giacomo, E., Leone, B. E., Clerici, M., Grassia, F. Tags: PostScript Source Type: research

Humoral and cellular responses to SARS-CoV-2 vaccination in patients with autoantibody-mediated neuroimmunology
Introduction COVID-19 caused by SARS-CoV-2 is still prevalent worldwide. In Japan, two types of mRNA vaccines, BNT162b2 and mRNA-1273, have been widely administered. Neuromyelitis optica spectrum disorder (NMOSD) and myasthenia gravis (MG) are representative autoantibody-mediated neuroimmunological diseases. Majority of the patients are required to take immunosuppressive medication. In this regard, there is an urgent need to clarify the immune responses elicited by SARS-CoV-2 mRNA vaccination to elucidate its efficacy and the potential immune flare in these patients. Insufficient humoral immune responses and potent SARS-Co...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 15, 2023 Category: Neurosurgery Authors: Kihara, K., Kinoshita, M., Sugimoto, T., Okazaki, S., Murata, H., Beppu, S., Shiraishi, N., Sugiyama, Y., Koda, T., Okuno, T., Mochizuki, H. Tags: COVID-19 PostScript Source Type: research

Prevalence, incidence and clinical features of neuromyelitis optica spectrum disorders in northern Japan
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disorder of the central nervous system that predominantly targets the optic nerve and spinal cord. In 2001, we began conducting epidemiological surveys on multiple sclerosis (MS) and NMOSD in the Tokachi area of Hokkaido Island in Japan, and have since reported the data every 5 years. In the last survey in 2016, we first applied the 2015 criteria and reported that the prevalence of NMOSD in the Japanese population was similar to that in Caucasians.1 We conducted an epidemiological survey of NMOSD in 2021 to determine the prevalence and clinical ch...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 15, 2023 Category: Neurosurgery Authors: Houzen, H., Kano, T., Kondo, K., Takahashi, T., Niino, M. Tags: PostScript Source Type: research

Ocrelizumab concentration and antidrug antibodies are associated with B-cell count in multiple sclerosis
Conclusions Serum ocrelizumab concentration was strongly associated with B-cell count. Measurement of ocrelizumab drug concentrations and ADAs could play an important role to further personalise treatment and predict the start of B-cell repopulation. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 15, 2023 Category: Neurosurgery Authors: Toorop, A. A., Hogenboom, L., Bloem, K., Kocyigit, M., Commandeur, N. W. M., Wijnants, A., Lissenberg-Witte, B. I., Strijbis, E. M. M., Uitdehaag, B. M. J., Rispens, T., Killestein, J., van Kempen, Z. L. E. Tags: Multiple sclerosis Source Type: research

Decrease of natalizumab drug levels after switching from intravenous to subcutaneous administration in patients with multiple sclerosis
Conclusions Natalizumab trough drug levels can decrease after switching from natalizumab intravenous to SC administration. We advise to monitor trough drug levels in patients with low natalizumab drug levels during intravenous treatment, patients with higher body mass index or patients on extended treatment intervals who switch to SC administration of natalizumab. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 15, 2023 Category: Neurosurgery Authors: Toorop, A. A., van Kempen, Z. L. E., Steenhuis, M., Nielsen, J., Sinnige, L. G. F., van Dijk, G., Roosendaal, C. M., Arnoldus, E. P. J., Hoitsma, E., Lissenberg-Witte, B. I., de Jong, B. A., Oosten, B. W. v., Strijbis, E. M. M., Uitdehaag, B. M. J., Rispe Tags: JNNP Patients' choice Multiple sclerosis Source Type: research

Effectiveness of an outpatient rehabilitation programme in patients with neuralgic amyotrophy and scapular dyskinesia: a randomised controlled trial
Conclusion This RCT shows that an MR programme focused on motor relearning to improve scapular dyskinesia, combined with self-management strategies for reducing pain and fatigue, shows more beneficial effects on shoulder, arm and hand functional capability than UC in patients with NA. Trial registration number NCT03441347. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 15, 2023 Category: Neurosurgery Authors: Janssen, R. M. J., Lustenhouwer, R., Cup, E. H. C., van Alfen, N., Ijspeert, J., Helmich, R. C., Cameron, I. G. M., Geurts, A. C. H., van Engelen, B. G. M., Graff, M. J. L., Groothuis, J. T. Tags: Neuromuscular Source Type: research

Effectiveness of early cycles of fast-acting treatment in generalised myasthenia gravis
Conclusion Early cycles of intervention with EFT and early use of calcineurin inhibitors provides long-term benefits in terms of achieving therapeutic targets for generalised MG, regardless of clinical subtype. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 15, 2023 Category: Neurosurgery Authors: Uzawa, A., Suzuki, S., Kuwabara, S., Akamine, H., Onishi, Y., Yasuda, M., Ozawa, Y., Kawaguchi, N., Kubota, T., Takahashi, M. P., Suzuki, Y., Watanabe, G., Kimura, T., Sugimoto, T., Samukawa, M., Minami, N., Masuda, M., Konno, S., Nagane, Y., Utsugisawa, Tags: Neuromuscular Source Type: research

Cognitive performance is associated with glomerular filtration rate in patients with chronic kidney disease: results from the CKD-REIN cohort
Conclusions In patients with CKD, lower eGFR was associated with worse cognitive performance and incident cognitive events, independently of demographics, CV risk factors and depression. Trial registration number NCT03381950. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 15, 2023 Category: Neurosurgery Authors: Pepin, M., Levassort, H., Boucquemont, J., Lambert, O., Alencar de Pinho, N., Turinici, M., Helmer, C., Metzger, M., Cheddani, L., Frimat, L., Combe, C., Fouque, D., Laville, M., Ayav, C., Liabeuf, S., Jacquelinet, C., Teillet, L., Stengel, B., Massy, Z. Tags: Cognitive neurology Source Type: research

Structural and functional changes in the retina in Parkinsons disease
Parkinson’s disease is caused by degeneration of dopaminergic neurons, originating in the substantia nigra pars compacta and characterised by bradykinesia, rest tremor and rigidity. In addition, visual disorders and retinal abnormalities are often present and can be identified by decreased visual acuity, abnormal spatial contrast sensitivity or even difficulty in complex visual task completion. Because of their early onset in patients with de novo Parkinson’s disease, the anatomical retinal changes and electrophysiological modification could be valuable markers even at early stages of the disease. However, due ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 15, 2023 Category: Neurosurgery Authors: Alves, J. N., Westner, B. U., Hojlund, A., Weil, R. S., Dalal, S. S. Tags: Neurodegeneration Source Type: research

GSN gene frameshift mutations in Alzheimers disease
Conclusions GSN frameshift mutations may be associated with AD. An increase in plasma GSN is probably a compensatory reaction in AD, which is a potential biomarker for early AD. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 15, 2023 Category: Neurosurgery Authors: Jiang, Y., Wan, M., Xiao, X., Lin, Z., Liu, X., Zhou, Y., Liao, X., Lin, J., Zhou, H., Zhou, L., Weng, L., Wang, J., Guo, J., Jiang, H., Zhang, Z., Xia, K., Li, J., Tang, B., Jiao, B., Shen, L. Tags: Open access Neurodegeneration Source Type: research

Elevated plasma p-tau181 levels unrelated to Alzheimers disease pathology in amyotrophic lateral sclerosis
Conclusions Plasma p-tau181 is elevated in patients with ALS, independently from CSF levels, and is firmly associated with LMN dysfunction. The finding indicates that p-tau181 of putative peripheral origin might represent a confounding factor in using plasma p-tau181 for AD pathology screening, which deserves further investigation. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 15, 2023 Category: Neurosurgery Authors: Vacchiano, V., Mastrangelo, A., Zenesini, C., Baiardi, S., Avoni, P., Polischi, B., Capellari, S., Salvi, F., Liguori, R., Parchi, P., on behalf of the BoReALS group, Cinelli, Stasi, Plasmati, Pastorelli, Quarta, Milletti, Nasca, Rizzi, Santoro, Valeriani Tags: Editor's choice Neurodegeneration Source Type: research