Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF- κB pathway
Impaired osteo-/angiogenesis, excessive inflammation, and imbalance of the osteoimmune homeostasis are involved in the pathogenesis of the alveolar bone defect caused by periodontitis. Unfortunately, there is ... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 6, 2024 Category: Nanotechnology Authors: Shi-Yuan Yang, Yue Hu, Ran Zhao, Yu-Ning Zhou, Yu Zhuang, Yan Zhu, Xiao-Li Ge, Ting-Wei Lu, Kai-Li Lin and Yuan-Jin Xu Tags: Research Source Type: research
Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation
The prognosis for hepatocellular carcinoma (HCC) remains suboptimal, characterized by high recurrence and metastasis rates. Although metalloimmunotherapy has shown potential in combat... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 6, 2024 Category: Nanotechnology Authors: Qianying Du, Ying Luo, Lian Xu, Chier Du, Wenli Zhang, Jie Xu, Yun Liu, Bo Liu, Sijin Chen, Yi Wang, Zhigang Wang, Haitao Ran, Junrui Wang and Dajing Guo Tags: Research Source Type: research
Nanoplastics causes heart aging/myocardial cell senescence through the Ca2+/mtDNA/cGAS-STING signaling cascade
Nanoplastics (NPs) are now a new class of pollutants widely present in the soil, atmosphere, freshwater and marine environments. Nanoplastics can rapidly penetrate cell membranes and accumulate in human tissue... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 6, 2024 Category: Nanotechnology Authors: Kaihao Wang, Yipeng Du, Peixin Li, Chang Guan, Min Zhou, Lanlan Wu, Zengfu Liu and Zheng Huang Tags: Research Source Type: research
Nano-enabled agrochemicals: mitigating heavy metal toxicity and enhancing crop adaptability for sustainable crop production
The primary factors that restrict agricultural productivity and jeopardize human and food safety are heavy metals (HMs), including arsenic, cadmium, lead, and aluminum, which adversely impact crop yields and q... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 5, 2024 Category: Nanotechnology Authors: Abazar Ghorbani, Abolghassem Emamverdian, Necla Pehlivan, Meisam Zargar, Seyed Mehdi Razavi and Moxian Chen Tags: Review Source Type: research
Spike structure of gold nanobranches induces hepatotoxicity in mouse hepatocyte organoid models
Gold nanoparticles (GNPs) have been extensively recognized as an active candidate for a large variety of biomedical applications. However, the clinical conversion of specific types of GNPs has been hindered du... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 5, 2024 Category: Nanotechnology Authors: Rui Zhang, Dan Li, Ruibo Zhao, Dandan Luo, Yeting Hu, Shengyan Wang, Xiaolu Zhuo, M. Zubair Iqbal, Han Zhang, Qianqian Han and Xiangdong Kong Tags: Research Source Type: research
Glioma-targeted oxaliplatin/ferritin clathrate reversing the immunosuppressive microenvironment through hijacking Fe2+ and boosting Fenton reaction
Glioma is easy to develop resistance to temozolomide (TMZ). TMZ-resistant glioma secretes interleukin-10 (IL-10) and transforming growth factor- β (TGF-β), recruiting regulatory T cell (Treg) and inhibiting the ac... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 5, 2024 Category: Nanotechnology Authors: Xue Li, Ying Cheng, Zhifu Yang, Qifeng Ji, Menglei Huan, Weiliang Ye, Miao Liu, Bangle Zhang, Daozhou Liu and Siyuan Zhou Tags: Research Source Type: research
Microfluidics-enabled fluorinated assembly of EGCG-ligands-siTOX nanoparticles for synergetic tumor cells and exhausted t cells regulation in cancer immunotherapy
Immune checkpoint inhibitor (ICI)-derived evolution offers a versatile means of developing novel immunotherapies that targets programmed death-ligand 1 (PD-L1)/programmed death-1 (PD-1) axis. However, one majo... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 4, 2024 Category: Nanotechnology Authors: Xiaowei Han, Guozheng Zhang, Xiaozhen Wu, Shufeng Xu, Jiahuan Liu, Kaikai Wang, Tianqing Liu and Pengkai Wu Tags: Research Source Type: research
EphA2-specific microvesicles derived from tumor cells facilitate the targeted delivery of chemotherapeutic drugs for osteosarcoma therapy
Despite advances in surgery and chemotherapy, the survival of patients with osteosarcoma (OS) has not been fundamentally improved over the last two decades. Microvesicles (MVs) have a high cargo-loading capaci... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 3, 2024 Category: Nanotechnology Authors: Zhenggang Wang, Zhiyi He, Junlai Wan, Anmin Chen, Peng Cheng and Wentao Zhu Tags: Research Source Type: research
Facile synthesis of Gd/Ru-doped fluorescent carbon dots for fluorescent/MR bimodal imaging and tumor therapy
Functional metal doping endows fluorescent carbon dots with richer physical and chemical properties, greatly expanding their potential in the biomedical field. Nonetheless, fabricating carbon dots with integra... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 2, 2024 Category: Nanotechnology Authors: Yupeng Shi, Yaning Xia, Mengyang Zhou, Yifei Wang, Jianfeng Bao, Yong Zhang and Jingliang Cheng Tags: Research Source Type: research
Correction: Natural ursolic acid based self-therapeutic polymer as nanocarrier to deliver natural resveratrol for natural therapy of acute kidney injury
(Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 1, 2024 Category: Nanotechnology Authors: Yuanpeng Nie, Liying Wang, Shengbo Liu, Chunlei Dai, Tianjiao Cui, Yan Lei, Xinru You, Xiaohua Wang, Jun Wu and Zhihua Zheng Tags: Correction Source Type: research
Promoting collateral formation in type 2 diabetes mellitus using ultra-small nanodots with autophagy activation and ROS scavenging
Impaired collateral formation is a major factor contributing to poor prognosis in type 2 diabetes mellitus (T2DM) patients with atherosclerotic cardiovascular disease. However, the current pharmacological trea... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 1, 2024 Category: Nanotechnology Authors: Yixuan Wang, Feifei Li, Linshuang Mao, Yu Liu, Shuai Chen, Jingmeng Liu, Ke Huang, Qiujing Chen, Jianrong Wu, Lin Lu, Yuanyi Zheng, Weifeng Shen, Tao Ying, Yang Dai and Ying Shen Tags: Research Source Type: research
An overview on mRNA-based vaccines to prevent monkeypox infection
The human monkeypox virus (Mpox) is classified as a member of the Poxviridae family and belongs to the Orthopoxvirus genus. Mpox possesses double-stranded DNA, and there are two known genetic clades: those ori... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 1, 2024 Category: Nanotechnology Authors: Mohammad Natami, Amirsasan Gorgzadeh, Arsalan Gholipour, Seyedeh Narges Fatemi, Nima Firouzeh, Maryam Zokaei, Saad Hasan Mohammed Ali, Hadis Kheradjoo, Somayeh Sedighi, Omid Gholizadeh and Shaylan Kalavi Tags: Review Source Type: research
Macrophage membrane (MMs) camouflaged near-infrared (NIR) responsive bone defect area targeting nanocarrier delivery system (BTNDS) for rapid repair: promoting osteogenesis via phototherapy and modulating immunity
Bone defects remain a significant challenge in clinical orthopedics, but no targeted medication can solve these problems. Inspired by inflammatory targeting properties of macrophages, inflammatory microenviron... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 1, 2024 Category: Nanotechnology Authors: Peng Xue, Zhiyong Chang, Hao Chen, Hongzhong Xi, Xiaoxue Tan, Shuai He, Haishi Qiao, Xiaohong Jiang, Xin Liu and Bin Du Tags: Research Source Type: research
Development of finely tuned liposome nanoplatform for macrophage depletion
Immunotherapy with clodronate-encapsulated liposomes, which induce macrophage depletion, has been studied extensively. However, previously reported liposomal formulation-based drugs (Clodrosome ® and m-Clodrosome® (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - February 29, 2024 Category: Nanotechnology Authors: Tae Hyeon Choi, Ran Ji Yoo, Ji Yong Park, Ji Yoon Kim, Young Chan Ann, Jeongbin Park, Jin Sil Kim, Kyuwan Kim, Yu Jin Shin, Yong Jin Lee, Kyo Chul Lee, Jisu Park, Hyewon Chung, Seung Hyeok Seok, Hyung-Jun Im and Yun-Sang Lee Tags: Research Source Type: research
A novel extracellular vesicles production system harnessing matrix homeostasis and macrophage reprogramming mitigates osteoarthritis
Osteoarthritis (OA) is a degenerative disease that significantly impairs quality of life. There is a pressing need for innovative OA therapies. While small extracellular vesicles (sEVs) show promising therapeu... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - February 28, 2024 Category: Nanotechnology Authors: Tianqi Wang, Hongqi Zhao, Yi Zhang, Yanshi Liu, Jialin Liu, Ge Chen, Ke Duan, Zhong Li, Hoi Po James Hui and Jiyuan Yan Tags: Research Source Type: research
