[ASAP] Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00822 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 30, 2023 Category: Chemistry Authors: Mingming Qi, Hui Zhong, Zhaoyan Cheng, Shujie Chen, Han Xiao, Jing Shang, Li Chen, and Jianbo Sun Source Type: research
[ASAP] Discovery of 1 < italic toggle="yes" > H < /italic > ‑Imidazo[4,5‑ < italic toggle="yes" > b < /italic > ]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00372 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 29, 2023 Category: Chemistry Authors: Xuetao Chen, Danyan Cao, Chihong Liu, Fanying Meng, Zijian Zhang, Rujun Xu, Yuanyuan Tong, Yabing Xin, Weikun Zhang, Wenjing Kang, Qichao Bao, Jingkang Shen, Bing Xiong, Qidong You, and Zhengyu Jiang Source Type: research
[ASAP] Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00405 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 29, 2023 Category: Chemistry Authors: Xin Han, Lijie Zhao, Weiguo Xiang, Bukeyan Miao, Chong Qin □, Mi Wang, Tianfeng Xu, Donna McEachern, Jianfeng Lu, Yu Wang, Hoda Metwally, Chao-Yie Yang△, Paul D. Kirchhoff, Lu Wang, Aleksas Matvekas, John Takyi-Williams, Bo Wen, Duxin Sun, Mark Ator, Source Type: research
[ASAP] Alicyclic Ring Size Variation of 4 ‑Phenyl-2-naphthoic Acid Derivatives as P2Y < sub > 14 < /sub > Receptor Antagonists
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00664 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 29, 2023 Category: Chemistry Authors: Zhiwei Wen, Asmita Pramanik, Sarah A. Lewicki, Young-Hwan Jung, Zhan-Guo Gao, John C. R. Randle, Chunxia Cronin, Zhoumou Chen, Luigino A. Giancotti, Gregory S. Whitehead, Bruce T. Liang, Sylvie Breton, Daniela Salvemini, Donald N. Cook, and Kenneth A. Jac Source Type: research
[ASAP] Design, Synthesis, Molecular Docking, and Biological Evaluation of Novel Pimavanserin-Based Analogues as Potential Serotonin 5 ‑HT < sub > 2A < /sub > Receptor Inverse Agonists
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00662 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 28, 2023 Category: Chemistry Authors: Nader R. Albujuq, J. Javier Meana, Rebeca Diez-Alarcia, Itziar Muneta-Arrate, Arshi Naqvi, Khalid Althumayri, and Mosa Alsehli Source Type: research
[ASAP] Correction to “Recent Update on the Development of PCSK9 Inhibitors for Hypercholesterolemia Treatment”
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c01112 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 28, 2023 Category: Chemistry Authors: Shakir Ahamad and Shahnawaz A. Bhat Source Type: research
[ASAP] Optimization of Drug-Linker to Enable Long-term Storage of Antibody –Drug Conjugate for Subcutaneous Dosing
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00794 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 28, 2023 Category: Chemistry Authors: Adrian D. Hobson, Jianwen Xu, Christopher C. Marvin, Michael J. McPherson, Markus Hollmann, Michael Gattner, Kristina Dzeyk, Margaret M. Fettis, Agnieszka K. Bischoff, Lu Wang, Julia Fitzgibbons, Lu Wang, Paulin Salomon, Axel Hernandez, Jr., Ying Jia, Het Source Type: research
[ASAP] Targeting the Estrogen Receptor for the Treatment of Breast Cancer: Recent Advances and Challenges
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00136 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 28, 2023 Category: Chemistry Authors: Rohan Kalyan Rej, Junius Eugene Thomas II, Ranjan Kumar Acharyya, James Michael Rae, and Shaomeng Wang Source Type: research
[ASAP] Degradation of Hexokinase 2 Blocks Glycolysis and Induces GSDME-Dependent Pyroptosis to Amplify Immunogenic Cell Death for Breast Cancer Therapy
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00118 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 28, 2023 Category: Chemistry Authors: Ruoxi Sang, Renming Fan, Aohua Deng, Jiakui Gou, Ruizhuo Lin, Ting Zhao, Yongrui Hai, Junke Song, Yang Liu, Bing Qi, Guanhua Du, Maosheng Cheng, and Gaofei Wei Source Type: research
[ASAP] Rational Design of Gd-DOTA-Type Contrast Agents for Hepatobiliary Magnetic Resonance Imaging
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00579 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 28, 2023 Category: Chemistry Authors: Weiyuan Xu, Yi Lu, Jiao Xu, Huaping Li, Rongfeng Lan, Ruonan Gao, Yinghui Ding, Xinjian Ye, Kun Shu, Fangfu Ye, Zhihan Yan, and Lixiong Dai Source Type: research
[ASAP] Correction to “An Analysis of Successful Hit-to-Clinical Candidate Pairs”
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c01063 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 27, 2023 Category: Chemistry Authors: Dean G. Brown Source Type: research
[ASAP] Potent Dual Inhibitors of Steroid Sulfatase and 17 β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for < italic toggle="yes" > In Vivo < /italic > Proof-of-Principle Studies in an Endometriosis Mouse Model
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00571 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 27, 2023 Category: Chemistry Authors: Mohamed Salah, Mariam Tahoun, Jeannette Rudzitis-Auth, Lisa Stotz, Chris J. van Koppen, Matthias W. Laschke, Ahmed S. Abdelsamie, and Martin Frotscher Source Type: research
[ASAP] Structure –Activity Relationship Study of Antimicrobial Peptide PE2 Delivered Novel Linear Derivatives with Potential of Eradicating Biofilms and Low Incidence of Drug Resistance
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00181 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 27, 2023 Category: Chemistry Authors: Jingying Zhang, Xu Ouyang, Fangyan Zhang, Beibei Li, Linlin Chang, Ping Yang, Wenbo Mao, Sanhu Gou, Yun Zhang, Hui Liu, Jia Yao, and Jingman Ni Source Type: research
[ASAP] Targeting Arginine Methyltransferase PRMT5 for Cancer Therapy: Updated Progress and Novel Strategies
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00250 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 27, 2023 Category: Chemistry Authors: Jiahong Zheng, Bang Li, Yingqi Wu, Xiaoshuang Wu, and Yuanxiang Wang Source Type: research
[ASAP] Preferred Conformation-Guided Discovery of Potent and Orally Active HIF Prolyl Hydroxylase 2 Inhibitors for the Treatment of Anemia
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00231 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 27, 2023 Category: Chemistry Authors: Yue Wu, Linjian Zhang, Zhuoli Sun, Xusheng Qiu, Yafen Chen, Kaijun Su, Le Yang, Zhongqiu Du, Ying Dong, Fulai Yang, Xiang Li, and Xiaojin Zhang Source Type: research
