[ASAP] Rationally Designed Nonapeptides with Great Skin Photoprotective Effect through Producing Type 1 Collagen and Blocking the mTOR Pathway
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00503 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 29, 2023 Category: Chemistry Authors: Xu Wang, Wenzhuang Shi, Kang Wang, Zifan Ye, Runying Wang, Hui Wang, Huaixin Yang, Zeping Xie, Haining Yu, and Yipeng Wang Source Type: research
[ASAP] Discovery of the First Subnanomolar PPAR α/δ Dual Agonist for the Treatment of Cholestatic Liver Diseases
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c02123 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 27, 2023 Category: Chemistry Authors: Zhiqi Feng, Jiehao Xiang, Gang Sun, Hui Liu, Yanyan Wang, Xin Liu, Jin Feng, Qinglong Xu, Xiaoan Wen, Haoliang Yuan, Hongbin Sun, and Liang Dai Source Type: research
[ASAP] Discovery of 2 ‑(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase‑3 (GSK-3) Inhibitors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00364 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 26, 2023 Category: Chemistry Authors: Richard A. Hartz, Vijay T. Ahuja, Guanglin Luo, Ling Chen, Prasanna Sivaprakasam, Hong Xiao, Carol M. Krause, Wendy J. Clarke, Songmei Xu, John S. Tokarski, Kevin Kish, Hal Lewis, Nicolas Szapiel, Ramu Ravirala, Sayali Mutalik, Deepa Nakmode, Devang Shah, Source Type: research
[ASAP] Novel Medicinal Chemistry Strategies Targeting CDK5 for Drug Discovery
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00566 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 26, 2023 Category: Chemistry Authors: Wentao Tang, Congcong Lin, Quanwei Yu, Dan Zhang, Yun Liu, Lele Zhang, Zhilan Zhou, Jifa Zhang, and Liang Ouyang Source Type: research
[ASAP] Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00398 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 26, 2023 Category: Chemistry Authors: Satish R. Malwal, Ben Mazurek, Jihee Ko, Pujun Xie, Chikako Barnes, Christine Varvitsiotis, Matthew D. Zimmerman, Samir Olatunji, Jaeyong Lee, Min Xie, Jansy Sarathy, Martin Caffrey, Natalie C. J. Strynadka, Ve ́ronique Dartois, Thomas Dick, Bom Nae Rin Source Type: research
[ASAP] Anti-cocaine Vaccine Development: Where Are We Now and Where Are We Going?
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00366 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 25, 2023 Category: Chemistry Authors: Rachel J. Stephenson and Istvan Toth Source Type: research
[ASAP] Antagonistic Insulin Derivative Suppresses Insulin-Induced Hypoglycemia
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00280 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 25, 2023 Category: Chemistry Authors: Claire Park, Yanxian Zhang, Jae Un Jung, Line Due Buron, Nai-Pin Lin, Thomas Hoeg-Jensen, and Danny Hung-Chieh Chou Source Type: research
[ASAP] Correction to “Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction”
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00892 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 25, 2023 Category: Chemistry Authors: Hailing Chen, Meimiao Zhan, Jianbo Liu, Zhihong Liu, Minhong Shen, Fenfang Yang, Yibin Kang, Feng Yin, and Zigang Li Source Type: research
[ASAP] Carbohydrate Strengthens the Immunotherapeutic Effect of Small-Molecule PD-L1 Inhibitors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01347 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 25, 2023 Category: Chemistry Authors: Qian Dong, Mengya Tong, Xiaolu Yu, Lei Wang, Jiwei Ao, Dongliang Guan, Yubo Tang, Junjie Liu, Li Long, Yongliang Tong, Shanhua Fang, Hu Zhou, Yongzhuo Huang, Likun Gong, Liguang Lou, and Wei Huang Source Type: research
[ASAP] To Fold or Not to Fold: Diastereomeric Optimization of an α‑Helical Antimicrobial Peptide
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00460 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 25, 2023 Category: Chemistry Authors: Hippolyte Personne, Thierry Paschoud, Sofia Fulgencio, Ste ́phane Baeriswyl, Thilo Köhler, Christian van Delden, Achim Stocker, Sacha Javor, and Jean-Louis Reymond Source Type: research
[ASAP] Design and Optimization of Novel Benzimidazole- and Imidazo[4,5 ‑ < italic toggle="yes" > b < /italic > ]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c02104 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 25, 2023 Category: Chemistry Authors: Teodor Dimitrov, Athina Anastasia Moschopoulou, Lennart Seidel, Thales Kronenberger, Mark Kudolo, Antti Poso, Christian Geibel, Pascal Wo ̈lffing, Daniel Dauch, Lars Zender, Dieter Schollmeyer, Jürgen Bajorath, Michael Forster, and Stefan Laufer Source Type: research
[ASAP] Design and Evaluation of a Low Hydrogen Bond Donor Count Fragment Screening Set to Aid Hit Generation of PROTACs Intended for Oral Delivery
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00493 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 24, 2023 Category: Chemistry Authors: Benjamin C. Whitehurst, Matthias R. Bauer, Fredrik Edfeldt, Anders Gunnarsson, Christian Margreitter, Philip B. Rawlins, and R. Ian Storer Source Type: research
[ASAP] An Analysis of Successful Hit-to-Clinical Candidate Pairs
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00521 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 24, 2023 Category: Chemistry Authors: Dean G. Brown Source Type: research
[ASAP] Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00150 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 23, 2023 Category: Chemistry Authors: Lin Ma, Yingying Li, Ruixiang Luo, Yuhan Wang, Jiaqi Cao, Weitao Fu, Bolan Qian, Lei Zheng, Longguang Tang, Xinting Lv, Lulu Zheng, Guang Liang, and Lingfeng Chen Source Type: research
[ASAP] Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00088 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - May 23, 2023 Category: Chemistry Authors: Yang Zhou, Hang Yu, Anna Constance Vind, Lulu Kong, Yiling Liu, Xiaojuan Song, Zhengchao Tu, Caihong Yun, Jeff B. Smaill, Qing-Wen Zhang, Ke Ding, Simon Bekker-Jensen, and Xiaoyun Lu Source Type: research
