[ASAP] New Generation of sGC Stimulators: Discovery of Imidazo[1,2 ‑ < italic toggle="yes" > a < /italic > ]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c02082 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 11, 2023 Category: Chemistry Authors: Alexandros Vakalopoulos, Frank Wunder, Ingo V. Hartung, Gorden Redlich, Rolf Jautelat, Philipp Buchgraber, Jorma Hassfeld, Alexey V. Gromov, Niels Lindner, Donald Bierer, Jo ̈rg Gries, Walter Kroh, Holger Paulsen, Joachim Mittendorf, Dieter Lang, Eva Bec Source Type: research
[ASAP] 1 ‑ < italic toggle="yes" > O < /italic > ‑Octadecyl-2‑ < italic toggle="yes" > O < /italic > ‑benzyl- < italic toggle="yes" > sn < /italic > -glyceryl-3- < italic toggle="yes" > phospho < /italic > -GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV ‑2 Infection and Synthesis and Antiviral Evaluation of Additional Phospholipid Esters with Enhanced Anti-SARS-CoV‑2 Activity
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00046 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 11, 2023 Category: Chemistry Authors: Aaron F. Carlin, James R. Beadle, Alex E. Clark, Kendra L. Gully, Fernando R. Moreira, Ralph S. Baric, Rachel L. Graham, Nadejda Valiaeva, Sandra L. Leibel, William Bray, Rachel E. McMillan, Jonathan E. Freshman, Aaron F. Garretson, Rachael N. McVicar, Ta Source Type: research
[ASAP] Bioactivity-Driven Synthesis of the Marine Natural Product Naamidine J and Its Derivatives as Potential Tumor Immunological Agents by Inhibiting Programmed Death-Ligand 1
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01702 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 11, 2023 Category: Chemistry Authors: Pan-Pan Fu, Qun Wang, Qing Zhang, Yang Jin, Jin Liu, Kai-Xian Chen, Yue-Wei Guo, San-Hong Liu, and Xu-Wen Li Source Type: research
[ASAP] Discovery of BRD4 –HDAC Dual Inhibitors with Improved Fungal Selectivity and Potent Synergistic Antifungal Activity against Fluconazole-Resistant < named-content content-type="genus-species" xlink:type="simple" > Candida albicans < /named-content >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00165 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 10, 2023 Category: Chemistry Authors: Zhuang Li, Yahui Huang, Jie Tu, Wanzhen Yang, Na Liu, Wei Wang, and Chunquan Sheng Source Type: research
[ASAP] Development and Characterization of Benzoselenazole Derivatives as Potent and Selective < italic toggle="yes" > c ‑MYC < /italic > Transcription Inhibitors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01808 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 10, 2023 Category: Chemistry Authors: Tian-Ying Wu, Xiu-Cai Chen, Gui-Xue Tang, Wen Shao, Zhang-Chi Li, Shuo-Bin Chen, Zhi-Shu Huang, and Jia-Heng Tan Source Type: research
[ASAP] Factor XIa Inhibitors in Anticoagulation Therapy: Recent Advances and Perspectives
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c02130 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 10, 2023 Category: Chemistry Authors: Zhouling Xie, Zhiwei Meng, Xiaoxiao Yang, Yajun Duan, Qin Wang, and Chenzhong Liao Source Type: research
[ASAP] Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01864 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 10, 2023 Category: Chemistry Authors: Yang Gao, Baishan Jiang, Hellen Kim, Matthew J. Berberich, Jianwei Che, Katherine A. Donovan, John M. Hatcher, Fidel Huerta, Nicholas P. Kwiatkowski, Yingpeng Liu, Peter P. Liuni, Rebecca J. Metivier, Vineeth K. Murali, Radosaw P. Nowak, Tinghu Zhang, Eri Source Type: research
[ASAP] Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Inhibitors of CDK8 for the Treatment of Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01718 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 7, 2023 Category: Chemistry Authors: Yangguang Li, Yingtao Liu, Jianping Wu, Xiaosong Liu, Lin Wang, Ju Wang, Jiaojiao Yu, Hongyun Qi, Luoheng Qin, Xiao Ding, Feng Ren, and Alex Zhavoronkov Source Type: research
[ASAP] Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c02046 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 7, 2023 Category: Chemistry Authors: Nan-Nan Chen, Han Zhang, Qiang-Sheng Zhu, Ting Zeng, Wei Dai, Ye-Ling Zhou, Guo-Feng Xin, Bei-Duo Wu, Si-Jia Gong, Zheng-Yu Jiang, Qi-Dong You, and Xiao-Li Xu Source Type: research
[ASAP] Correction to “Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate”
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00494 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 7, 2023 Category: Chemistry Authors: Adrian D. Hobson, Michael J. McPherson, Martin E. Hayes, Christian Goess, Xiang Li, Jian Zhou, Zhongyuan Wang, Yajie Yu, Jindong Yang, Liang Sun, Qiang Zhang, Pei Qu, Shi Yang, Axel Hernandez, Jr., Shaughn H. Bryant, Suzanne L. Mathieu, Agnieszka K. Bisch Source Type: research
[ASAP] Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c02089 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 7, 2023 Category: Chemistry Authors: Hua-Lin Zhou, Alfred Hausladen, Puneet Anand, Malligarjunan Rajavel, Colin T. Stomberski, Rongli Zhang, Richard T. Premont, William J. Greenlee, Focco van den Akker, and Jonathan S. Stamler Source Type: research
[ASAP] Neurotherapeutic Potential of Water-Soluble pH-Responsive Prodrugs of EIDD-036 in Traumatic Brain Injury
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01484 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 7, 2023 Category: Chemistry Authors: Russell G. Fritzemeier, Aletta E. van der Westhuyzen, Michael D ’Erasmo, Savita K. Sharma, Perry Bartsch, Luke E. Hodson, Ken Liu, Bushra Wali, Iqbal Sayeed, and Dennis C. Liotta Source Type: research
[ASAP] Design, Synthesis, < italic toggle="yes" > In Vitro < /italic > and < italic toggle="yes" > In Vivo < /italic > Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00276 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 7, 2023 Category: Chemistry Authors: Nicoletta Brindani, Linh M. Vuong, Isabella Maria Acquistapace, Maria Antonietta La Serra, Jose ́ Antonio Ortega, Marina Veronesi, Sine Mandrup Bertozzi, Maria Summa, Stefania Girotto, Rosalia Bertorelli, Andrea Armirotti, Anand K. Ganesan, and Marco De Source Type: research
[ASAP] Discovery of an < italic toggle="yes" > In Vivo < /italic > Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00155 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 7, 2023 Category: Chemistry Authors: Alice C. Harnden, Owen A. Davis, Gary M. Box, Angela Hayes, Louise D. Johnson, Alan T. Henley, Alexis K. de Haven Brandon, Melanie Valenti, Kwai-Ming J. Cheung, Alfie Brennan, Rosemary Huckvale, Olivier A. Pierrat, Rachel Talbot, Michael D. Bright, Hafize Source Type: research
[ASAP] Acetyl-Click Screening Platform Identifies Small-Molecule Inhibitors of Histone Acetyltransferase 1 (HAT1)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00039 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - April 7, 2023 Category: Chemistry Authors: Jitender D. Gaddameedi, Tristan Chou, Benjamin S. Geller, Amithvikram Rangarajan, Tarun A. Swaminathan, Danielle Dixon, Katherine Long, Caiden J. Golder, Van A. Vuong, Selene Banuelos, Robert Greenhouse, Michael P. Snyder, Andrew M. Lipchik, and Joshua J. Source Type: research
