[ASAP] The Importance of PK –PD
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00514 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 29, 2023 Category: Chemistry Authors: James C. Barrow(Associate Editor) and Craig W. Lindsley(Editor-in-Chief) Source Type: research

[ASAP] Development of Son of Sevenless Homologue 1 (SOS1) Modulators To Treat Cancers by Regulating RAS Signaling
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01729 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 29, 2023 Category: Chemistry Authors: Guangmei Luo, Bingrui Wang, Qiangqiang Hou, and Xiaoxing Wu Source Type: research

[ASAP] Discovery and Binding Mechanism of Pyrazoloisoquinoline-Based Novel β‑Arrestin Inverse Agonists of the Kappa-Opioid Receptor
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00064 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 29, 2023 Category: Chemistry Authors: Jae-Hoon Jung, In Hee Jang, Moon Young Yang, Sunhong Kim, Soo-Kyung Kim, William A. Goddard, III, and Yong-Chul Kim Source Type: research

[ASAP] Design and Pharmacological Characterization of α < sub > 4 < /sub > β < sub > 1 < /sub > Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Antagonism
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c02098 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 28, 2023 Category: Chemistry Authors: Michele Anselmi, Monica Baiula, Santi Spampinato, Roberto Artali, Tingting He, and Luca Gentilucci ¥ Source Type: research

[ASAP] Synthesis and Evaluation of < sup > 99m < /sup > Tc-Labeled FAP Inhibitors with Different Linkers for Imaging of Fibroblast Activation Proteins in Tumors
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c02062 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 27, 2023 Category: Chemistry Authors: Qing Ruan, Qianna Wang, Yuhao Jiang, Junhong Feng, Guangxing Yin, and Junbo Zhang Source Type: research

[ASAP] Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00175 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 27, 2023 Category: Chemistry Authors: Valentina Albanese, Sonia Missiroli, Mariasole Perrone, Martina Fabbri, Caterina Boncompagni, Salvatore Pacifico, Tiziano De Ventura, Antonella Ciancetta, Giulio Dondio, Franz Kricek, Paolo Pinton, Remo Guerrini, Delia Preti, and Carlotta Giorgi Source Type: research

[ASAP] Perspective for Discovery of Small Molecule IL ‑6 Inhibitors through Study of Structure–Activity Relationships and Molecular Docking
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01957 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 27, 2023 Category: Chemistry Authors: Hossam Nada, Aneesh Sivaraman, Qili Lu, Kyoungho Min, Sungdo Kim, Ja-Il Goo, Yongseok Choi, and Kyeong Lee Source Type: research

[ASAP] Structure –Activity Relationships of Truncated 1′-Homologated Carbaadenosine Derivatives as New PPARγ/δ Ligands: A Study on Sugar Puckering Affecting Binding to PPARs
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c02071 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 27, 2023 Category: Chemistry Authors: Young Eum Hyun, Seungchan An, Minjae Kim, In Guk Park, Sanghee Yoon, Hafiz Muhammad Ahmad Javaid, Thi Ngoc Lan Vu, Gyudong Kim, Hongseok Choi, Hyuk Woo Lee, Minsoo Noh, Joo Young Huh, Sun Choi, Hong-Rae Kim, and Lak Shin Jeong Source Type: research

[ASAP] Photoacidolysis-Mediated Iridium(III) Complex for Photoactive Antibacterial Therapy
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c02000 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 26, 2023 Category: Chemistry Authors: Yue Li, Shuangling Luo, Haobing Wang, Yidan Lai, Dan Li, Qianling Zhang, Huaiyi Huang, and Pingyu Zhang Source Type: research

[ASAP] Discovery of Clinically Used Octenidine as < italic toggle="yes" > NRAS < /italic > Repressor That Effectively Inhibits < italic toggle="yes" > NRAS < /italic > -Mutant Melanoma
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00094 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 24, 2023 Category: Chemistry Authors: Xiu-Cai Chen, Gui-Xue Tang, Jing Dai, Le-Tian Dai, Tian-Ying Wu, Wen-Wei Li, Tian-Miao Ou, Zhi-Shu Huang, Jia-Heng Tan, and Shuo-Bin Chen Source Type: research

[ASAP] An Overview of Antivirals against Monkeypox Virus and Other Orthopoxviruses
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00069 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 24, 2023 Category: Chemistry Authors: Jun Wang, Md Shahed-AI-Mahmud, Angelo Chen, Kan Li, Haozhou Tan, and Ryan Joyce Source Type: research

[ASAP] Design and Structural Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High In Vivo Potency and Oral Bioavailability
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c02006 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 24, 2023 Category: Chemistry Authors: Silong Zhang, Luolong Qing, Ziwei Wang, Yu Zhang, Yuanyuan Li, Huaxiang Fang, Yi Liu, and Huan He Source Type: research

[ASAP] Design, Synthesis, and Biological Evaluation of Androgen Receptor (AR) Antagonist-Heat Shock Protein 90 (Hsp90) Inhibitor Conjugates for Targeted Therapy of Castration-Resistant Prostate Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01970 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 24, 2023 Category: Chemistry Authors: Siqi Zhang, Xiaolei Meng, Sai Zhang, Baohu Li, Wencong Jin, Chengwei Zhang, Zhaojuan Liu, Xiaolin Hu, Ling Ge, Zhonghao Yu, Zhuoyue Li, Shumin Ma, Xiao Wang, Liming Li, and Chong Qin Source Type: research

[ASAP] Serine-/Cysteine-Based sp < sup > 2 < /sup > ‑Iminoglycolipids as Novel TLR4 Agonists: Evaluation of Their Adjuvancy and Immunotherapeutic Properties in a Murine Model of Asthma
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01948 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 23, 2023 Category: Chemistry Authors: Manuel Gonza ́lez-Cuesta, Alan Chuan-Ying Lai, Po-Yu Chi, I-Ling Hsu, Nien-Tzu Liu, Ko-Chien Wu, José M. García Fernández, Ya-Jen Chang, and Carmen Ortiz Mellet Source Type: research

[ASAP] Discovery of Potent and Highly Selective Interleukin-2-Inducible T ‑Cell Kinase Degraders with < italic toggle="yes" > In Vivo < /italic > Activity
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c02078 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - March 23, 2023 Category: Chemistry Authors: Danli Zhou, Yingying Zuo, and Zhengying Pan Source Type: research