[ASAP] Hydrogel-Encapsulated Biofilm Inhibitors Abrogate the Cariogenic Activity of < named-content content-type="genus-species" xlink:type="simple" > Streptococcus mutans < /named-content >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00272 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 7, 2023 Category: Chemistry Authors: Parmanand Ahirwar, Veronika Kozlovskaya, Bhavitavya Nijampatnam, Edwin M. Rojas, Piyasuda Pukkanasut, Daniel Inman, Maksim Dolmat, Anna C. Law, Norbert Schormann, Champion Deivanayagam, Gregory J. Harber, Suzanne M. Michalek, Hui Wu, Eugenia Kharlampieva, Source Type: research
[ASAP] 6 ‑Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: < italic toggle="yes" > In Silico < /italic > Design, Synthesis, and X ‑ray Crystallography
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00433 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 7, 2023 Category: Chemistry Authors: Alessio Nocentini, Alessandro Bonardi, Carla Bazzicalupi, Vincenzo Alterio, Davide Esposito, Simona Maria Monti, Michael Smietana, Giuseppina De Simone, Claudiu T. Supuran, Paola Gratteri, and Jean-Yves Winum Source Type: research
[ASAP] Tuning the Metabolic Stability of Visual Cycle Modulators through Modification of an RPE65 Recognition Motif
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00461 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 6, 2023 Category: Chemistry Authors: Marco Bassetto, Jordan Zaluski, Bowen Li, Jianye Zhang, Mohsen Badiee, Philip D. Kiser, and Gregory P. Tochtrop Source Type: research
[ASAP] Discovery and Design of Novel Cyclic Peptides as Specific Inhibitors Targeting CCN2 and Disrupting CCN2/EGFR Interaction for Kidney Fibrosis Treatment
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00594 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 6, 2023 Category: Chemistry Authors: Jiale Dong, Jing Xiao, Jianyi Li, Huan Yu, Qian Zhao, Qinglin Tang, Hui Chen, Han Liu, Kejue Wu, Jinping Lei, Rui Wang, and Xianxing Jiang Source Type: research
[ASAP] Discovery of the First Potent, Selective, and < italic toggle="yes" > In Vivo < /italic > Efficacious Polo-like Kinase 4 Proteolysis Targeting Chimera Degrader for the Treatment of < italic toggle="yes" > TRIM37 < /italic > -Amplified Breast Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00505 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 6, 2023 Category: Chemistry Authors: Yin Sun, Yanli Xue, Pengkun Sun, Shuyi Mu, Hongbing Liu, Yu Sun, Lin Wang, Jingkai Wang, Tianxiao Wu, Wenbo Yin, Qiaohua Qin, Yixiang Sun, Nian Liu, Hanxun Wang, Huali Yang, Dongmei Zhao, and Maosheng Cheng Source Type: research
[ASAP] Near-Infrared-Activatable PROTAC Nanocages for Controllable Target Protein Degradation and On-Demand Antitumor Therapy
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00587 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 6, 2023 Category: Chemistry Authors: Qi He, Liming Zhou, Daxin Yu, Ren Zhu, Yue Chen, Mingbo Song, Xintong Liu, Yixian Liao, Tong Ding, Wenpei Fan, and Wenying Yu Source Type: research
[ASAP] Physicochemical Property Determinants of Oral Absorption for PROTAC Protein Degraders
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00740 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 6, 2023 Category: Chemistry Authors: Keith R. Hornberger and Erika M. V. Araujo Source Type: research
[ASAP] Serum-Stable Gold(III) Bisphosphine Complex Induces Mild Mitochondrial Uncoupling and In Vivo Antitumor Potency in Triple Negative Breast Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00238 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 6, 2023 Category: Chemistry Authors: Adedamola S. Arojojoye, Chibuzor Olelewe, Sailajah Gukathasan, Jong H. Kim, Hemendra Vekaria, Sean Parkin, Patrick G. Sullivan, and Samuel G. Awuah Source Type: research
[ASAP] Discovery of Exceptionally Potent, Selective, and Efficacious PROTAC Degraders of CBP and p300 Proteins
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00492 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 5, 2023 Category: Chemistry Authors: Junius Eugene Thomas, II, Mi Wang, Wei Jiang, Meilin Wang, Lu Wang, Bo Wen, Duxin Sun, and Shaomeng Wang Source Type: research
[ASAP] Discovery of Dimethyl Shikonin Oxime 5a, a Potent, Selective Bombesin Receptor Subtype ‑3 Agonist for the Treatment of Type 2 Diabetes Mellitus
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00323 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 5, 2023 Category: Chemistry Authors: Lehao Wu, Jiahua Cui, Chunxiao Zhao, Zeyuan Wang, Jihong Lu, Shaoshun Li, Jinping Jia, Hua Xiao, and Yan Zhang Source Type: research
[ASAP] The Zinc-Binding Group Effect: Lessons from Non-Hydroxamic Acid Vorinostat Analogs
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00226 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 5, 2023 Category: Chemistry Authors: Silke Geurs, Dorien Clarisse, Karolien De Bosscher, and Matthias D ’hooghe Source Type: research
[ASAP] Structure-Based Design and Characterization of the Highly Potent and Selective Covalent Inhibitors Targeting the Lysine Methyltransferases G9a/GLP
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00411 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 2, 2023 Category: Chemistry Authors: Zongbo Feng, Chunju Yang, Yi Zhang, Huaxuan Li, Wei Fang, Junhua Wang, Yichu Nie, Chang-Yun Wang, Zhiqing Liu, Zhimin Jiang, Junjian Wang, and Yuanxiang Wang Source Type: research
[ASAP] Structure –Activity Relationship Studies of the Aryl Acetamide Triazolopyridazines against < italic toggle="yes" > Cryptosporidium < /italic > Reveals Remarkable Role of Fluorine
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00110 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 2, 2023 Category: Chemistry Authors: Tanner J. Schubert, Edmund Oboh, Hannah Peek, Emily Philo, Jose ́ E. Teixeira, Erin E. Stebbins, Peter Miller, Jonathan Oliva, Francis M. Sverdrup, David W. Griggs, Christopher D. Huston, and Marvin J. Meyers Source Type: research
[ASAP] Discovery of Small-Molecule Degraders for Alpha-Synuclein Aggregates
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00274 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 2, 2023 Category: Chemistry Authors: Yichen Tong, Wentao Zhu, Jian Chen, Tianzhi Wen, Fang Xu, and Jiyan Pang Source Type: research
[ASAP] Exploring Structure –Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00189 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 2, 2023 Category: Chemistry Authors: Anna Rovira, Enrique Ortega-Forte, Cormac Hally, Mireia Jorda ̀-Redondo, Diego Abad-Montero, Gloria Vigueras, Jesús I. Martínez, Manel Bosch, Santi Nonell, José Ruiz, and Vicente Marchán Source Type: research
