[ASAP] Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2 ′)-Orn-NH < sub > 2 < /sub > ] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2 ′)-Arg-NH < sub > 2 < /sub > ]
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00432 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 12, 2023 Category: Chemistry Authors: Mark D. Ericson, Linh T. Tran, Sarah S. Mathre, Katie T. Freeman, Kelsey Holdaway, Kristen John, Mary M. Lunzer, Jacob L. Bouchard, and Carrie Haskell-Luevano Source Type: research
[ASAP] Discovery of Platinum < sup > IV < /sup > –Artesunate Multiaction Prodrugs as Potent Antitumor and Antimalarial Agents
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00396 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 12, 2023 Category: Chemistry Authors: Wei Liu, Chuyi Yu, Miaomiao Wang, Youyou He, Zhongjie Guo, Jin He, Ru Jiang, Qin Xu, Jianming Liang, and Shengzheng Wang Source Type: research
[ASAP] Hypsochromic Shift Donor –Acceptor NIR-II Dye for High-Efficiency Tumor Imaging
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00253 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 9, 2023 Category: Chemistry Authors: Jiafeng Li, Aiyan Ji, Meiling Lei, Liwen Xuan, Ruihu Song, Xin Feng, Haixia Lin, and Hao Chen Source Type: research
[ASAP] Reaction Behavior of [1,3-Diethyl-4,5-diphenyl ‑1 < italic toggle="yes" > H < /italic > ‑imidazol-2-ylidene] Containing Gold(I/III) Complexes against Ingredients of the Cell Culture Medium and the Meaning on the Potential Use for Cancer Eradication Therapy
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00589 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 9, 2023 Category: Chemistry Authors: Paul Kapitza, Amelie Scherfler, Stefan Salcher, Sieghart Sopper, Monika Cziferszky, Klaus Wurst, and Ronald Gust Source Type: research
[ASAP] Evolution and Discovery of Matrine Derivatives as a New Class of Anti-Hepatic Fibrosis Agents Targeting Ewing Sarcoma Breakpoint Region 1 (EWSR1)
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00286 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 9, 2023 Category: Chemistry Authors: Yunyang Bao, Tianyu Niu, Jingyang Zhu, Yuheng Mei, Yulong Shi, Runze Meng, Qionglu Duan, Na Zhang, Tianyun Fan, Yanxiang Wang, Yudong Pang, Yinghong Li, Hongwei He, and Danqing Song Source Type: research
[ASAP] Structure-Based Discovery of Inhibitors of the SARS-CoV ‑2 Nsp14 N7-Methyltransferase
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c02120 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 9, 2023 Category: Chemistry Authors: Isha Singh, Fengling Li, Elissa A. Fink, Irene Chau, Alice Li, Anni ́a Rodriguez-Hernández, Isabella Glenn, Francisco J. Zapatero-Belinchón, M. Luis Rodriguez, Kanchan Devkota, Zhijie Deng, Kris White, Xiaobo Wan, Nataliya A. Tolmachova⧫, Yurii S. Source Type: research
[ASAP] Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00229 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 9, 2023 Category: Chemistry Authors: Duncan E. Shaw, Nichola Smith, Rene Beerli, Simona Cotesta, Pier-Luca D ’Alessandro, Anne-Marie Edwards, Rene Lattmann, Dimitrios Lizos, Robert Pulz, Lisa Rooney, Bindi Sohal, Caroline Rynn, Jessica Taylor, Thomas Troxler, Gareth Williams, Sabine Guth, Source Type: research
[ASAP] NSAID –Au(I) Complexes Induce ROS-Driven DAMPs and Interpose Inflammation to Stimulate the Immune Response against Ovarian Cancer
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00063 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 9, 2023 Category: Chemistry Authors: Zhongren Xu, Qiuyue Lu, Min Shan, Guizhi Jiang, Yuanhao Liu, Zhibin Yang, Yunlong Lu, and Wukun Liu Source Type: research
[ASAP] Precise Conformational Control Yielding Highly Potent and Exceptionally Selective BRD4 Degraders with Strong Antitumor Activity
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00520 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 8, 2023 Category: Chemistry Authors: Jiantao Hu, Biao Hu, Fuming Xu, Mi Wang, Chong Qin, Donna McEachern, Jeanne Stuckey, and Shaomeng Wang Source Type: research
[ASAP] Design, Radiosynthesis, and Evaluation of New Fluorinated Analogs of MeDAS for Myelin PET Imaging
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00325 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 8, 2023 Category: Chemistry Authors: Se ́bastien Beuché, Marie-Anne Peyronneau, Benoit Jego, Caroline Denis, Paul Bourbon, Capucine Chauvière, Cyrille Santerre, Charles Truillet, Bertrand Kuhnast, and Fabien Caillé Source Type: research
[ASAP] Discovery of Novel 5,6-Dihydro-1,2,4-triazine Derivatives as Efficacious Glucagon-Like Peptide ‑1 Receptor Agonists
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00320 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 7, 2023 Category: Chemistry Authors: Lili Chen, Ying Yun, Shimeng Guo, Xiaoyan Wang, Muya Xiong, Tingting Zhao, Tifei Xu, Jianhua Shen, Xin Xie, and Kai Wang Source Type: research
[ASAP] Development of Novel < sup > 111 < /sup > In/ < sup > 225 < /sup > Ac-Labeled Agent Targeting PSMA for Highly Efficient Cancer Radiotheranostics
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00346 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 7, 2023 Category: Chemistry Authors: Shohei Tsuchihashi, Kazuma Nakashima, Yuta Tarumizu, Hiroaki Ichikawa, Hiroki Jinda, Hiroyuki Watanabe, and Masahiro Ono Source Type: research
[ASAP] Platinum(IV) Derivatives of [Pt(1 < italic toggle="yes" > S < /italic > ,2 < italic toggle="yes" > S < /italic > ‑diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00269 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 7, 2023 Category: Chemistry Authors: Hana Kostrhunova, Brondwyn S. McGhie, Lenka Markova, Olga Novakova, Jana Kasparkova, Janice R. Aldrich-Wright, and Viktor Brabec Source Type: research
[ASAP] The Role of Allylic Strain for Conformational Control in Medicinal Chemistry
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00446 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 7, 2023 Category: Chemistry Authors: Hongtao Zhao, Jonas Br ånalt, Matthew Perry, and Christian Tyrchan Source Type: research
[ASAP] Identification of a pH-Responsive Peptide –Paclitaxel Conjugate as a Novel Drug with Improved Therapeutic Potential
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00382 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 7, 2023 Category: Chemistry Authors: Syed Faheem Askari Rizvi, Nadir Abbas, Haixia Zhang, and Quan Fang Source Type: research
