Journal of Mammary Gland Biology and Neoplasia 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492
In this study, we demonstrate expression of PXDN in breast epithelium and stroma and apply the D492 cell line to investigate the role ofPXDN in cell differentiation and branching morphogenesis in the human breast. Overexpression ofPXDN induced basal phenotype in D492 cells, loss of plasticity and inhibition of epithelial-to-mesenchymal transition as is displayed by complete inhibition of branching morphogenesis in 3D culture. This is supported by results from RNA-sequencing which show significant enrichment in genes involved in epithelial differentiation along with significant negative enrichment of EMT factors. Taken toge...
Source: Journal of Mammary Gland Biology and Neoplasia - December 28, 2021 Category: Cancer & Oncology Source Type: research
Nfatc1 ’s Role in Mammary Epithelial Morphogenesis and Basal Stem/progenitor Cell Self-renewal
AbstractMammary gland is an outstanding system to study the regulatory mechanisms governing adult epithelial stem cell activity. Stem cells in the basal layer of the mammary gland fuel the morphogenesis and regeneration of a complex epithelial network during development and upon transplantation. The self-renewal of basal stem/progenitor cells is subjected to regulation by both cell-intrinsic and extrinsic mechanisms. Nfatc1 is a transcription factor that regulates breast tumorigenesis and metastasis, but its role in mammary epithelial development and stem cell function has not been investigated. Here we show thatNfatc1 is ...
Source: Journal of Mammary Gland Biology and Neoplasia - December 21, 2021 Category: Cancer & Oncology Source Type: research
Advances in Analyzing the Breast Cancer Lipidome and Its Relevance to Disease Progression and Treatment
AbstractAbnormal lipid metabolism is common in breast cancer with the three main subtypes, hormone receptor (HR) positive, human epidermal growth factor 2 (HER2) positive, and triple negative, showing common and distinct lipid dependencies. A growing body of studies identify altered lipid metabolism as impacting breast cancer cell growth and survival, plasticity, drug resistance, and metastasis. Lipids are a class of nonpolar or polar (amphipathic) biomolecules that can be produced in cells via de novo synthesis or acquired from the microenvironment. The three main functions of cellular lipids are as essential components o...
Source: Journal of Mammary Gland Biology and Neoplasia - December 16, 2021 Category: Cancer & Oncology Source Type: research
Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492
In this study, we demonstrate expression of PXDN in breast epithelium and stroma and apply the D492 cell line to investigate the role ofPXDN in cell differentiation and branching morphogenesis in the human breast. Overexpression ofPXDN induced basal phenotype in D492 cells, loss of plasticity and inhibition of epithelial-to-mesenchymal transition as is displayed by complete inhibition of branching morphogenesis in 3D culture. This is supported by results from RNA-sequencing which show significant enrichment in genes involved in epithelial differentiation along with significant negative enrichment of EMT factors. Taken toge...
Source: Journal of Mammary Gland Biology and Neoplasia - December 1, 2021 Category: Cancer & Oncology Source Type: research
Stromal Changes are Associated with High P4HA2 Expression in Ductal Carcinoma in Situ of the Breast
This study included 410 patients with DCIS. Stromal changes were scored on hematoxylin/eosin-stained whole slides. P4HA2 expression in DCIS-associated stroma was assessed by whole slide immunohistochemistry. One hundred DCIS lesions were evaluated by seven pathologists to study the interobserver v ariability in the assessment of stromal changes and stromal P4HA2 expression. High P4HA2 expression in stromal fibroblasts was present in 14.1% of the patients. High P4HA2 expression was associated with the presence of periductal stromal changes (P = 0.004). The interobserver variability was si milar for the assessment of st...
Source: Journal of Mammary Gland Biology and Neoplasia - December 1, 2021 Category: Cancer & Oncology Source Type: research
Local Heat Treatment of Goat Udders Influences Innate Immune Functions in Mammary Glands
In conclusion, a local rise in udder temperature enhanced the innate immune function in mammary glands by increasing antimicrobial components. (Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - December 1, 2021 Category: Cancer & Oncology Source Type: research
Colostrogenesis: Role and Mechanism of the Bovine Fc Receptor of the Neonate (FcRn)
AbstractColostrogenesis is a separate and unique phase of mammary epithelial cell activity occurring in the weeks before parturition and rather abruptly ending after birth in the bovine. It has been the focus of research to define what controls this process and how it produces high concentrations of specific biologically active components important for the neonate. In this review we consider colostrum composition and focus upon components that appear in first milked colostrum in concentrations exceeding that in blood serum. The Fc Receptor of the Neonate (FcRn) is recognized as the major immunoglobulin G (IgG) and albumin ...
Source: Journal of Mammary Gland Biology and Neoplasia - December 1, 2021 Category: Cancer & Oncology Source Type: research
Chloroquine Induces ROS-mediated Macrophage Migration Inhibitory Factor Secretion and Epithelial to Mesenchymal Transition in ER-positive Breast Cancer Cell Lines
In this study, we found that the genetic inhibition of autophagy primed cells for EMT by inducing a decrease in E-cadherin protein levels, while CQ treatment decreased E-cadherin levels, induced morphological changes related to EMT, increased EMT-related transcription factor (EMT-TF) expression and migration in estrogen receptor positive (ER +) BC cell lines. Importantly, CQ treatment increased intracellular reactive oxygen species (ROS) which induced the secretion of macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine related to malignancy. Both ROS production and MIF secretion were responsible fo...
Source: Journal of Mammary Gland Biology and Neoplasia - December 1, 2021 Category: Cancer & Oncology Source Type: research
Altered Epithelial-mesenchymal Plasticity as a Result of Ovol2 Deletion Minimally Impacts the Self-renewal of Adult Mammary Basal Epithelial Cells
AbstractStem-cell containing mammary basal epithelial cells exist in a quasi-mesenchymal transcriptional state characterized by simultaneous expression of typical epithelial genes and typical mesenchymal genes. Whether robust maintenance of such a transcriptional state is required for adult basal stem cells to fuel self-renewal and regeneration remains unclear. In this work, we utilizedSMA-CreER to direct efficient basal cell-specific deletion ofOvol2, which encodes a transcription factor that inhibits epithelial-to-mesenchymal transition (EMT), in adult mammary gland. We identified a basal cell-intrinsic role ofOvol2 in p...
Source: Journal of Mammary Gland Biology and Neoplasia - December 1, 2021 Category: Cancer & Oncology Source Type: research
Advances in Analyzing the Breast Cancer Lipidome and Its Relevance to Disease Progression and Treatment
AbstractAbnormal lipid metabolism is common in breast cancer with the three main subtypes, hormone receptor (HR) positive, human epidermal growth factor 2 (HER2) positive, and triple negative, showing common and distinct lipid dependencies. A growing body of studies identify altered lipid metabolism as impacting breast cancer cell growth and survival, plasticity, drug resistance, and metastasis. Lipids are a class of nonpolar or polar (amphipathic) biomolecules that can be produced in cells via de novo synthesis or acquired from the microenvironment. The three main functions of cellular lipids are as essential components o...
Source: Journal of Mammary Gland Biology and Neoplasia - December 1, 2021 Category: Cancer & Oncology Source Type: research
Nfatc1 ’s Role in Mammary Epithelial Morphogenesis and Basal Stem/progenitor Cell Self-renewal
AbstractMammary gland is an outstanding system to study the regulatory mechanisms governing adult epithelial stem cell activity. Stem cells in the basal layer of the mammary gland fuel the morphogenesis and regeneration of a complex epithelial network during development and upon transplantation. The self-renewal of basal stem/progenitor cells is subjected to regulation by both cell-intrinsic and extrinsic mechanisms. Nfatc1 is a transcription factor that regulates breast tumorigenesis and metastasis, but its role in mammary epithelial development and stem cell function has not been investigated. Here we show thatNfatc1 is ...
Source: Journal of Mammary Gland Biology and Neoplasia - December 1, 2021 Category: Cancer & Oncology Source Type: research
Correction to: Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492
(Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - December 1, 2021 Category: Cancer & Oncology Source Type: research
Chloroquine Induces ROS-mediated Macrophage Migration Inhibitory Factor Secretion and Epithelial to Mesenchymal Transition in ER-positive Breast Cancer Cell Lines
In this study, we found that the genetic inhibition of autophagy primed cells for EMT by inducing a decrease in E-cadherin protein levels, while CQ treatment decreased E-cadherin levels, induced morphological changes related to EMT, increased EMT-related transcription factor (EMT-TF) expression and migration in estrogen receptor positive (ER +) BC cell lines. Importantly, CQ treatment increased intracellular reactive oxygen species (ROS) which induced the secretion of macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine related to malignancy. Both ROS production and MIF secretion were responsible fo...
Source: Journal of Mammary Gland Biology and Neoplasia - November 23, 2021 Category: Cancer & Oncology Source Type: research
Evolution and Self-renewal of the Journal of Mammary Gland Biology and Neoplasia
(Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - October 14, 2021 Category: Cancer & Oncology Source Type: research
