Journal of Mammary Gland Biology and Neoplasia This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

May Their Lineages Live on – an Editorial Board Tribute to Zena Werb and Gil Smith
(Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - October 23, 2020 Category: Cancer & Oncology Source Type: research

Studying Lymphatic Metastasis in Breast Cancer: Current Models, Strategies, and Clinical Perspectives
AbstractBreast cancer is the most commonly diagnosed cancer in women and the second most common cause of cancer-related deaths in the United States. Although early detection has significantly decreased breast cancer mortality, patients diagnosed with distant metastasis still have a very poor prognosis. The most common site that breast cancer spreads to are local lymph nodes. Therefore, the presence of lymph node metastasis remains one of most important prognostic factors in breast cancer patients. Given its significant clinical implications, increased efforts have been dedicated to better understand the molecular mechanism...
Source: Journal of Mammary Gland Biology and Neoplasia - October 9, 2020 Category: Cancer & Oncology Source Type: research

In Memoriam - Gilbert Howlett Smith 1938-2020
(Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - October 5, 2020 Category: Cancer & Oncology Source Type: research

Protocol: Adeno-Associated Virus-Mediated Gene Transfer in Ex Vivo Cultured Embryonic Mammary Gland
AbstractBranching morphogenesis of the murine mammary gland starts during late embryogenesis. It is regulated by the signals emanating both from the epithelium and the mesenchyme, yet the molecular mechanisms regulating this process remain poorly understood. We have previously developed a unique whole organ culture technique for embryonic mammary glands, which provides a powerful tool to monitor and manipulate branching morphogenesis ex vivo. Nowadays, RNA sequencing and other transcriptional profiling techniques provide robust methods to identify components of gene regulatory networks driving branching morphogenesis. Howe...
Source: Journal of Mammary Gland Biology and Neoplasia - October 1, 2020 Category: Cancer & Oncology Source Type: research

In Memoriam - Zena Werb 1945 –2020
(Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - September 29, 2020 Category: Cancer & Oncology Source Type: research

Distinct Expression Patterns of Fibrillar Collagen Types I, III, and V in Association with Mammary Gland Remodeling during Pregnancy, Lactation and Weaning
In this study, we investigated their expression patterns during pregnancy, parturition, lactation and involution. Type I collagen showed a well-developed fibril structure during pregnancy, but the fibrillar structure of type I collagen then became sparse at parturition and during lactation, which was concurrent with the downregulation of its mRNA and protein levels. The well-developed fibrillar structure of type I collagen reappeared after weaning. On the other hand, type V collagen showed a well-developed fibrillar structure and upregulation in the lactation period but not in the periods of pregnancy and involution. Type ...
Source: Journal of Mammary Gland Biology and Neoplasia - September 10, 2020 Category: Cancer & Oncology Source Type: research

The Multi-Faced Role of PAPP-A in Post-Partum Breast Cancer: IGF-Signaling is Only the Beginning
AbstractInsulin-like growth factor (IGF) signaling and control of local bioavailability of free IGF by the IGF binding proteins (IGFBP) are important regulators of both mammary development and breast cancer. A recent genome-wide association study (GWAS) identified small nucleotide polymorphisms that reduce the expression of IGFBP-5 as a risk factor of developing breast cancer. This observation suggests that genetic alterations leading to a decreased level of IGFBP-5 may also contribute to breast cancer. In the current review, we focus onPregnancy-AssociatedPlasmaProteinA (PAPP-A), a protease involved in the degradation of ...
Source: Journal of Mammary Gland Biology and Neoplasia - September 7, 2020 Category: Cancer & Oncology Source Type: research

H2AX Promoter Demethylation at Specific Sites Plays a Role in STAT5-Induced Tumorigenesis
AbstractDeregulated STAT5 activity in the mammary gland of transgenic mice results in parity-dependent latent tumorigenesis. The trigger for cell transformation was previously associated with hyperactivation of the H2AX proximal promoter in a small basal cell population during pregnancy. The current study focuses on the latent activation of tumor development. H2AX was highly expressed in carcinoma and adenocarcinoma as compared to the multiparous mammary gland, whereas pSTAT5 expression decreased in a tumor type-dependent manner. In contrast to the pregnant gland, no positive correlation between H2AX and pSTAT5 expression ...
Source: Journal of Mammary Gland Biology and Neoplasia - August 2, 2020 Category: Cancer & Oncology Source Type: research

Hoxd10 Is Required Systemically for Secretory Activation in Lactation and Interacts Genetically with Hoxd9
AbstractTargeted disruption of the murineHoxd10 gene( ΔHoxd10) leads to a high frequency of localized (gland-to-gland or regionally within a gland) lactation impairment in homozygous mutant mice as a single gene mutation. The effect ofHoxd10 disruption was enhanced by simultaneous disruption ofHoxd9 ( ΔHoxd9/d10), a mutation shown previously to have no effect on mammary function as a single gene alteration. Mammary glands of homozygousΔHoxd10 andΔHoxd9/d10 females were indistinguishable from those of wild type littermate and age-matched control mice in late pregnancy. However, in lactation, 47% of homozygousΔHoxd10 fe...
Source: Journal of Mammary Gland Biology and Neoplasia - July 22, 2020 Category: Cancer & Oncology Source Type: research

Intraductal Therapy in Breast Cancer: Current Status and Future Prospective
This article reviews the current status and future prospects of intraductal therapy in breast cancer, with emphasis on ductal carcinoma in situ. (Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - June 22, 2020 Category: Cancer & Oncology Source Type: research

Macphatics and PoEMs in Postpartum Mammary Development and Tumor Progression
In this report, we describe a subset of postpartum macrophages that express lymphatic proteins (PoEMs) and directly interact with lymphatic vessels to form chimeric vessels or “macphatics”. Additionally, th ese PoEMs are very similar to tumor-associated macrophages that also express lymphatic proteins and are present at the sites of lymphatic vessels where tumors escape the tissue and enter the lymphatic vasculature. Further characterizing these PoEMs may offer insight in preventing lymphatic metastasi s of breast cancer, as well as provide information for how developmental programming of lymphatic endothelial cells an...
Source: Journal of Mammary Gland Biology and Neoplasia - June 12, 2020 Category: Cancer & Oncology Source Type: research

Weighing the Risk: effects of Obesity on the Mammary Gland and Breast Cancer Risk
AbstractObesity is a preventable risk factor for breast cancer following menopause. Regardless of menopausal status, obese women who develop breast cancer have a worsened prognosis. Breast tissue is comprised of mammary epithelial cells organized into ducts and lobules and surrounded by adipose-rich connective tissue. Studies utilizing multiplein vivo models of obesity as well as human breast tissue have contributed to our understanding of how obesity alters mammary tissue. Localized changes in mammary epithelial cell populations, elevated secretion of adipokines and angiogenic mediators, inflammation within mammary adipos...
Source: Journal of Mammary Gland Biology and Neoplasia - June 8, 2020 Category: Cancer & Oncology Source Type: research

Breast Pathology That Contributes to Dysfunction of Human Lactation: a Spotlight on Nipple Blebs
AbstractNipple blebs are blister-like fibrinous lesions that form on the surface of the nipple during lactation, and can result in orifice obstruction and mastitis. They likely result from superficial extension of underlying ductal plugging, and can present concurrently with hyperlactation and mammary dysbiosis. Despite their prevalence, few formal reports on nipple blebs exist. In this perspective, we review the experience of a breastfeeding medicine practice that receives referrals for patients with nipple blebs, and provide preliminary insight into etiology, management, and outcomes of these lesions. (Source: Journal of...
Source: Journal of Mammary Gland Biology and Neoplasia - June 2, 2020 Category: Cancer & Oncology Source Type: research

Two Sides of the Same Coin: The Role of Developmental pathways and pluripotency factors in normal mammary stem cells and breast cancer metastasis
AbstractBreast cancer initiation and progression are often observed as the result of dysregulation of normal developmental processes and pathways. Studies focused on normal mammary stem/progenitor cell activity have led to an understanding of how breast cancer cells acquire stemness-associated properties including tumor initiation, survival and multi-lineage differentiation into heterogeneous tumors that become difficult to target therapeutically. Importantly, more recent investigations have provided valuable insight into how key developmental regulators can impact multiple phases of metastasis, where they are repurposed t...
Source: Journal of Mammary Gland Biology and Neoplasia - April 21, 2020 Category: Cancer & Oncology Source Type: research

Identification of an AP1-ZFP36 Regulatory Network Associated with Breast Cancer Prognosis
AbstractIt has been established that ZFP36 (also known as Tristetraprolin or TTP) promotes mRNA degradation of proteins involved in inflammation, proliferation and tumor invasiveness. In mammary epithelial cellsZFP36 expression is induced by STAT5 activation during lactogenesis, while in breast cancerZFP36 expression is associated with lower grade and better prognosis. Here, we show that the AP-1 transcription factor components, i.e.JUN, JUNB, FOS, FOSB, in addition toDUSP1, EGR1, NR4A1,IER2 andBTG2, behave as a conserved co-regulated group of genes whose expression is associated toZFP36 in cancer cells. In fact, a signifi...
Source: Journal of Mammary Gland Biology and Neoplasia - April 3, 2020 Category: Cancer & Oncology Source Type: research