Journal of Mammary Gland Biology and Neoplasia Journal of Mammary Gland Biology and Neoplasia RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

CCND1 Amplification in Breast Cancer -associations With Proliferation, Histopathological Grade, Molecular Subtype and Prognosis
In this study ofCCND1 in primary BCs and corresponding axillary lymph node metastases (LNM),we examine associations betweenCCND1 CN in primary BCs and proliferation status, molecular subtype, and prognosis. Furthermore, we studied associations betweenCCND1 CN and CNs ofFGFR1 andZNF703, both of which are located on 8p12.  Fluorescence in situ hybridization probes forCCND1 and chromosome 11 centromere were used on tissue microarrays comprising 526 BCs and 123 LNM. We assessed associations betweenCCND1 CN and tumour characteristics using Pearson ’s χ2 test, and estimated cumulative risks of death from BC and hazard rati...
Source: Journal of Mammary Gland Biology and Neoplasia - March 1, 2022 Category: Cancer & Oncology Source Type: research

Ductal Carcinoma in Situ: Molecular Changes Accompanying Disease Progression
AbstractDuctal carcinoma in situ (DCIS) is a non-obligate precursor of invasive ductal carcinoma  (IDC), whereby if left untreated, approximately 12% of patients develop invasive disease. The current standard of care is surgical removal of the lesion, to prevent potential progression, and radiotherapy to reduce risk of recurrence. There is substantial overtreatment of DCIS patients, considerin g not all DCIS lesions progress to invasive disease. Hence, there is a critical imperative to better predict which DCIS lesions are destined for poor outcome and which are not, allowing for tailored treatment. Active surveillance is...
Source: Journal of Mammary Gland Biology and Neoplasia - March 1, 2022 Category: Cancer & Oncology Source Type: research

Chronic Leptin Treatment Induces Epithelial-Mesenchymal Transition in MCF10A Mammary Epithelial Cells
This study aimed to evaluate the effect of chronic leptin treatment on the induction of EMT in MCF10A cells. We found that chronic leptin treatment induces a switch from an epithelial to a mesenchymal morphology, partial loss of E-cadherin and gain of vimentin expression. Immunolocalization experiments showed a partial loss of E-cadherin at cell junctions and increased cytoplasmic localization of vimentin in leptin-treated cells. Moreover, chronic leptin treatment increased collective cell migration and invasion. Furthermore, when cultured in non-adherent conditions leptin treated cells exhibited reduced cell aggregation, ...
Source: Journal of Mammary Gland Biology and Neoplasia - February 23, 2022 Category: Cancer & Oncology Source Type: research

Correction to: Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492
(Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - February 12, 2022 Category: Cancer & Oncology Source Type: research

Decoding Insulin-Like Growth Factor Signaling Pathway From a Non-coding RNAs Perspective: A Step Towards Precision Oncology in Breast Cancer
AbstractBreast cancer (BC) is a highly complex and heterogenous disease. Several oncogenic signaling pathways drive BC oncogenic activity, thus hindering scientists to unravel the exact molecular pathogenesis of such multifaceted disease. This highlights the urgent need to find a key regulator that tunes up such intertwined oncogenic drivers to trim the malignant transformation process within the breast tissue. The Insulin-like growth factor (IGF) signaling pathway is a tenacious axis that is heavily intertwined with BC where it modulates the amplitude and activity of vital downstream oncogenic signaling pathways. Yet, the...
Source: Journal of Mammary Gland Biology and Neoplasia - February 10, 2022 Category: Cancer & Oncology Source Type: research

Short Term Changes in Dietary Fat Content and Metformin Treatment During Lactation Impact Milk Composition and Mammary Gland Morphology
In this study we designed experiments to probe the mother-milk-infant triad in the condition of normal maternal health and upon exposure to high fat diet (HFD) with or without concurrent metformin exposure. We examined maternal characteristics, milk composition and offspring metabolic parameters on postnatal day 16, prior to offspring weaning. We found that lactational HFD increased maternal adipose tissue weight, mammary gland adipocyte size, and altered milk lipid composition causing a higher amount of omega-6 (n6) long chain fatty acids and lower omega-3 (n3). Offspring of HFD dams were heavier with more body fat during...
Source: Journal of Mammary Gland Biology and Neoplasia - February 9, 2022 Category: Cancer & Oncology Source Type: research

A CD8+ T Cell-Related Genes Expression Signature Predicts Prognosis and the Efficacy of Immunotherapy in Breast Cancer
This study aimed to establish a CD8+ T cell-related gene expression signature for prediction of breast cancer prognostic and immunotherapy efficacy. RNA-seq transcriptomic data was the basics of this research. Weighted gene co-expression network analysis (WGCNA) and the least absolute shrinkage and selection operator (LASSO) Cox regression analysis established the prognostic signature. We identified 290 CD8+ T cell-related genes in the training set and established a risk-score model based on 8-genes panel (SOCS1,IL10,CAMK4,CXCL13,KIR2DS4,TESPA1,CD70 andICAM4). Subsequently, univariate Cox regression analysis suggested that...
Source: Journal of Mammary Gland Biology and Neoplasia - January 27, 2022 Category: Cancer & Oncology Source Type: research

Colostrogenesis: Role and Mechanism of the Bovine Fc Receptor of the Neonate (FcRn)
AbstractColostrogenesis is a separate and unique phase of mammary epithelial cell activity occurring in the weeks before parturition and rather abruptly ending after birth in the bovine. It has been the focus of research to define what controls this process and how it produces high concentrations of specific biologically active components important for the neonate. In this review we consider colostrum composition and focus upon components that appear in first milked colostrum in concentrations exceeding that in blood serum. The Fc Receptor of the Neonate (FcRn) is recognized as the major immunoglobulin G (IgG) and albumin ...
Source: Journal of Mammary Gland Biology and Neoplasia - January 26, 2022 Category: Cancer & Oncology Source Type: research

Stromal Changes are Associated with High P4HA2 Expression in Ductal Carcinoma in Situ of the Breast
This study included 410 patients with DCIS. Stromal changes were scored on hematoxylin/eosin-stained whole slides. P4HA2 expression in DCIS-associated stroma was assessed by whole slide immunohistochemistry. One hundred DCIS lesions were evaluated by seven pathologists to study the interobserver v ariability in the assessment of stromal changes and stromal P4HA2 expression. High P4HA2 expression in stromal fibroblasts was present in 14.1% of the patients. High P4HA2 expression was associated with the presence of periductal stromal changes (P = 0.004). The interobserver variability was si milar for the assessment of st...
Source: Journal of Mammary Gland Biology and Neoplasia - January 25, 2022 Category: Cancer & Oncology Source Type: research

Local Heat Treatment of Goat Udders Influences Innate Immune Functions in Mammary Glands
In conclusion, a local rise in udder temperature enhanced the innate immune function in mammary glands by increasing antimicrobial components. (Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - January 11, 2022 Category: Cancer & Oncology Source Type: research

Altered Epithelial-mesenchymal Plasticity as a Result of Ovol2 Deletion Minimally Impacts the Self-renewal of Adult Mammary Basal Epithelial Cells
AbstractStem-cell containing mammary basal epithelial cells exist in a quasi-mesenchymal transcriptional state characterized by simultaneous expression of typical epithelial genes and typical mesenchymal genes. Whether robust maintenance of such a transcriptional state is required for adult basal stem cells to fuel self-renewal and regeneration remains unclear. In this work, we utilizedSMA-CreER to direct efficient basal cell-specific deletion ofOvol2, which encodes a transcription factor that inhibits epithelial-to-mesenchymal transition (EMT), in adult mammary gland. We identified a basal cell-intrinsic role ofOvol2 in p...
Source: Journal of Mammary Gland Biology and Neoplasia - January 4, 2022 Category: Cancer & Oncology Source Type: research