Journal of Mammary Gland Biology and Neoplasia This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Role of Phospholipid Flux during Milk Secretion in the Mammary Gland
AbstractLipids are a complex group of chemical compounds that are a significant component of the human diet and are one of the main constituents of milk. In mammals, lipids are produced in the milk-secreting cells in the form of milk fat globules. The chemical properties of these compounds necessitate developing separate processes for effective management of non-polar substances in the polar environment of the cell, not only during their biosynthesis and accumulation in the cell interior and secretion of intracytoplasmic lipid droplets outside the cell, but also during digestion in the offspring. Phospholipids play an impo...
Source: Journal of Mammary Gland Biology and Neoplasia - February 26, 2017 Category: Cancer & Oncology Source Type: research

The Terminal End Bud: the Little Engine that Could
AbstractThe mammary gland is one of the most regenerative organs in the body, with the majority of development occurring postnatally and in the adult mammal. Formation of the ductal tree is orchestrated by a specialized structure called the terminal end bud (TEB). The TEB is responsible for the production of mature cell types leading to the elongation of the subtending duct. The TEB is also the regulatory control point for basement membrane deposition, branching, angiogenesis, and pattern formation. While the hormonal control of TEB growth is well characterized, the local regulatory factors are less well understood. Recent...
Source: Journal of Mammary Gland Biology and Neoplasia - February 5, 2017 Category: Cancer & Oncology Source Type: research

Variation of Human Milk Glucocorticoids over 24  hour Period
This study shows that HM glucocorticoid concentrations exhibit a 24 hour pattern, with highest peak levels in the early morning, reflecting the c ircadian pattern as previously reported in plasma. Thus, HM glucocorticoid concentrations are likely to reflect those in the maternal circulation. (Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - January 30, 2017 Category: Cancer & Oncology Source Type: research

Reelin Deficiency Delays Mammary Tumor Growth and Metastatic Progression
AbstractReelin is a regulator of cell migration in the nervous system, and has other functions in the development of a number of non-neuronal tissues. In addition, alterations in reelin expression levels have been reported in breast, pancreatic, liver, gastric, and other cancers. Reelin is normally expressed in mammary gland stromal cells, but whether stromal reelin contributes to breast cancer progression is unknown. Herein, we used a syngeneic mouse mammary tumor transplantation model to examine the impact of host-derived reelin on breast cancer progression. We found that transplanted syngeneic tumors grew more slowly in...
Source: Journal of Mammary Gland Biology and Neoplasia - January 25, 2017 Category: Cancer & Oncology Source Type: research

Mouse Models of Breast Cancer Share Amplification and Deletion Events with Human Breast Cancer
AbstractBreast tumor heterogeneity has been well documented through the use of multiplatform –omic studies in human tumors. However, there is no integrative database to capture the heterogeneity within mouse models of breast cancer. This project identifies genomic copy number alterations (CNAs) in 600 tumors across 27 major mouse models of breast cancer through the application of a predic tive algorithm to publicly available gene expression data. It was found that despite the presence of strong oncogenic drivers in most mouse models, CNAs are extremely common but heterogeneous both between models and within models. Many ...
Source: Journal of Mammary Gland Biology and Neoplasia - January 25, 2017 Category: Cancer & Oncology Source Type: research