Journal of Mammary Gland Biology and Neoplasia 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Does the Mouse Mammary Gland Arise from Unipotent or Multipotent Mammary Stem/Progenitor Cells?
AbstractThe presence of long-lived lineage restricted progenitor and multipotent progenitor cells in adult mouse mammary gland for cancer development is compelling. Mammary cancers are phenotypically diverse This might be explained by transformation of long-lived, lineage-limited progenitor subpopulations. Mammary multipotent epithelial stem cells and their environmental niches must be considered, since their niche(s), once empty might be occupied by lineage-limited progenitors that are proximal. The existence of premalignant mammary populationst that manifest characteristics of lineage limitation argues strongly for this ...
Source: Journal of Mammary Gland Biology and Neoplasia - April 11, 2018 Category: Cancer & Oncology Source Type: research
Moderate High Temperature Condition Induces the Lactation Capacity of Mammary Epithelial Cells Through Control of STAT3 and STAT5 Signaling
In this study, we investigated whether temperature changes influence milk production ability and TJ barriers in MECs by using two lactating culture models. The results showed that 39 °C treatment activated milk production and enhanced the formation of less-permeable TJs. In contrast, 41 °C treatment caused adverse effects on the TJ barrier and cell viability, although the milk production ability of MECs was temporarily up-regulated. MECs cultured at 37 °C showed relativel y low milk production ability and high proliferation activity. Furthermore, we investigated three kinds of transcription factors relating to lacto...
Source: Journal of Mammary Gland Biology and Neoplasia - April 9, 2018 Category: Cancer & Oncology Source Type: research
Could use of Selective Serotonin Reuptake Inhibitors During Lactation Cause Persistent Effects on Maternal Bone?
AbstractThe lactating mammary gland elegantly coordinates maternal homeostasis to provide calcium for milk. During lactation, the monoamine serotonin regulates the synthesis and release of various mammary gland-derived factors, such as parathyroid hormone-related protein (PTHrP), to stimulate bone resorption. Recent evidence suggests that bone mineral lost during prolonged lactation is not fully recovered following weaning, possibly putting women at increased risk of fracture or osteoporosis. Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants have also been associated with reduced bone mineral density and increa...
Source: Journal of Mammary Gland Biology and Neoplasia - March 30, 2018 Category: Cancer & Oncology Source Type: research
Long-Chain Omega-3 Polyunsaturated Fatty Acids Modulate Mammary Gland Composition and Inflammation
This study investigated morphological alterations and inflammatory microenvironments in the MGs of adult mice fed isocaloric and isolipidic liquid diets with varying compositions of omega ( ω)-6 and long-chain (Lc)-ω3FA that were pair-fed. Despite similar consumption levels of the diets, mice fed the ω-3 diet had significantly lower body-weight gains, and abdominal-fat and mammary fat pad (MFP) weights. Fatty acid analysis showed significantly higher levels of Lc-ω-3FAs in the MFPs of mice on the ω-3 diet, while in the MFPs from the ω-6 group, Lc-ω-3FAs were undetectable. Our study revealed that MGs from ω-3 group ...
Source: Journal of Mammary Gland Biology and Neoplasia - March 25, 2018 Category: Cancer & Oncology Source Type: research
Milk Proteins Are Predigested Within the Human Mammary Gland
AbstractPrevious work demonstrates that proteases present in human milk release hundreds of peptides derived from milk proteins. However, the question of whether human milk protein digestion begins within the mammary gland remains incompletely answered. The primary objective of this study was to determine whether proteolytic degradation of human milk proteins into peptides begins within the mammary gland. The secondary objectives were to determine which milk proteases participate in the proteolysis and to predict which released peptides have bioactivity. Lactating mothers (n = 4) expressed their milk directly into a mi...
Source: Journal of Mammary Gland Biology and Neoplasia - February 20, 2018 Category: Cancer & Oncology Source Type: research
See One, Do One, Teach One: A Practical Course on Methods in Mammary Gland Biology
(Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - February 14, 2018 Category: Cancer & Oncology Source Type: research
Lipid Droplet Fusion in Mammary Epithelial Cells is Regulated by Phosphatidylethanolamine Metabolism
AbstractMammary epithelial cells (MEC) secrete fat in the form of milk fat globules (MFG) which are found in milk in diverse sizes. MFG originate from intracellular lipid droplets, and the mechanism underlying their size regulation is still elusive. Two main mechanisms have been suggested to control lipid droplet size. The first is a well-documented pathway, which involves regulation of cellular triglyceride content. The second is the fusion pathway, which is less-documented, especially in mammalian cells, and its importance in the regulation of droplet size is still unclear. Using biochemical and molecular inhibitors, we ...
Source: Journal of Mammary Gland Biology and Neoplasia - November 29, 2017 Category: Cancer & Oncology Source Type: research
Menin Modulates Mammary Epithelial Cell Numbers in Bovine Mammary Glands Through Cyclin D1
AbstractMenin, the protein encoded by theMEN1 gene, is abundantly expressed in the epithelial cells of mammary glands. Here, we foundMEN1/menin expression slowly decreased with advancing lactation but increased by the end of lactation. It happened that the number of bovine mammary epithelial cells decreases since lactation, suggesting a role of menin in the control of mammary epithelial cell growth. Indeed, reduction of menin expression throughMEN1-specific siRNA transfection in the bovine mammary epithelial cells caused cell growth arrest in G1/S phase. Decreased mRNA and protein expression of Cyclin D1 was observed uponM...
Source: Journal of Mammary Gland Biology and Neoplasia - November 29, 2017 Category: Cancer & Oncology Source Type: research
In Vitro Validation of the Hippo Pathway as a Pharmacological Target for Canine Mammary Gland Tumors
AbstractCanine mammary tumors (CMTs) are the most common neoplasms in intact female dogs. Some clinical and molecular similarities between certain CMT subtypes and breast cancer make them a potential model for the study of the human disease. As misregulated Hippo signaling is thought to play an important role in breast cancer development and also occurs in CMTs, we sought to determine if Hippo represents a valid pharmacological target for the treatment of CMTs. Six CMT cell lines were assessed for their expression of the Hippo pathway effectors YAP and TAZ and for their sensitivity to verteporfin, an inhibitor of YAP-media...
Source: Journal of Mammary Gland Biology and Neoplasia - August 18, 2017 Category: Cancer & Oncology Source Type: research
Monitoring In-Vivo the Mammary Gland Microstructure during Morphogenesis from Lactation to Post-Weaning Using Diffusion Tensor MRI
This study provides a basis for further in-vivo monitoring of changes during the mammary developmental stages, as well as identifying changes due to malignant transformation in patients with pregnancy associated breast cancer (PABC). (Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - July 13, 2017 Category: Cancer & Oncology Source Type: research
The Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis
AbstractSmoking cigarettes is one of the most concerning issues that leads to tobacco-related cancers and can even result in death. Therefore, these issues should be addressed with a great sense of urgency with low-cost and simple approaches. Over the past several years, the scientific community has attempted to find solutions to overcome this issue. Thus, a large number of excellent studies have been reported in this field, and summarizing these results and providing important roadmaps for future studies is currently of great importance. Finding an outstanding solution to address aforementioned issue would be of great val...
Source: Journal of Mammary Gland Biology and Neoplasia - June 29, 2017 Category: Cancer & Oncology Source Type: research
Impact of Metabolic Hormones Secreted in Human Breast Milk on Nutritional Programming in Childhood Obesity
AbstractObesity is the most common metabolic disease whose prevalence is increasing worldwide. This condition is considered a serious public health problem due to associated comorbidities such as diabetes mellitus and hypertension. Perinatal morbidity related to obesity does not end with birth; this continues affecting the mother/infant binomial and could negatively impact on metabolism during early infant nutrition. Nutrition in early stages of growth may be essential in the development of obesity in adulthood, supporting the concept of “nutritional programming”. For this reason, breastfeeding may play an important ro...
Source: Journal of Mammary Gland Biology and Neoplasia - June 27, 2017 Category: Cancer & Oncology Source Type: research
Innervation of the Male Breast: Psychological and Physiological Consequences
AbstractBreasts, including the nipple and areola, have two functions: lactation and as an erogenous area. Male breasts are much less studied that those of women. In men, breasts have only an erotic function. Because there is dense and very well organized innervation of the nipple-areola complex in men, nipple erection occurs frequently and via different mechanisms from penile erection. Although it seems to be less important for men than for women and it is poorly studied, the erotic value of breast stimulation is notable. Consequently, there is a need to include this aspect in sexological and andrological studies and to pr...
Source: Journal of Mammary Gland Biology and Neoplasia - May 27, 2017 Category: Cancer & Oncology Source Type: research
Developmental Expression of Claudins in the Mammary Gland
AbstractClaudins are a large family of membrane proteins whose classic function is to regulate the permeability of tight junctions in epithelia. They are tetraspanins, with four alpha-helices crossing the membrane, two extracellular loops, a short cytoplasmic N-terminus and a longer and more variable C-terminus. The extracellular ends of the helices are known to undergo side-to-side (cis) interactions that allow the formation of claudin polymers in the plane of the membrane. The extracellular loops also engage in head-to-head (trans) interactions thought to mediate the formation of tight junctions. However, claudins are al...
Source: Journal of Mammary Gland Biology and Neoplasia - April 28, 2017 Category: Cancer & Oncology Source Type: research
Current Update of Patient-Derived Xenograft Model for Translational Breast Cancer Research
AbstractDespite recent advances in the treatment of patients with breast cancer (BrCa), BrCa remains the third leading cause of cancer death for women in the US due to intrinsic or acquired resistance to therapy. Continued understanding of gene expression profiling and genomic sequencing has clarified underlying intratumoral molecular heterogeneity. Recently, the patient-derived xenograft (PDX) models have emerged as a novel tool to address the issues of BrCa genomics and tumor heterogeneity, and to critically transform translational BrCa research in the preclinical setting. PDX models are generated by xenografting cancer ...
Source: Journal of Mammary Gland Biology and Neoplasia - April 27, 2017 Category: Cancer & Oncology Source Type: research
