Journal of Mammary Gland Biology and Neoplasia This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Correction to: In Vivo Modeling of Human Breast Cancer Using Cell Line and Patient-Derived Xenografts
(Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - July 26, 2022 Category: Cancer & Oncology Source Type: research

Protein Tyrosine Phosphatase SHP2 Controls Interleukin-8 Expression in Breast Cancer Cells
In this study, we investigated cytokines affected by SHP2 that could be relevant for its pro-tumorigenic properties. We used a cytokine array to investigate differentially released cytokines in the supernatant of SHP2 inhibitor-treated breast cancer cells. Expression ofCXCL8 transcripts and protein abundance were assessed in human breast cancer cell lines in which we blocked SHP2 using shRNA constructs or an allosteric inhibitor. The impact of SHP2 inhibition on the phospho-tyrosine-proteome and signaling was determined using mass spectrometry. From previously published RNAseq data (Aceto et al. in Nat. Med. 18:529 –37,2...
Source: Journal of Mammary Gland Biology and Neoplasia - June 23, 2022 Category: Cancer & Oncology Source Type: research

In Vivo Modeling of Human Breast Cancer Using Cell Line and Patient-Derived Xenografts
AbstractHistorically, human breast cancer has been modeled largely in vitro using long-established cell lines primarily in two-dimensional culture, but also in three-dimensional cultures of varying cellular and molecular complexities. A subset of cell line models has also been used in vivo as cell line-derived xenografts (CDX). While outstanding for conducting detailed molecular analysis of regulatory mechanisms that may function in vivo, results of drug response studies using long-established cell lines have largely failed to translate clinically. In an attempt to address this shortcoming, many laboratories have succeeded...
Source: Journal of Mammary Gland Biology and Neoplasia - June 13, 2022 Category: Cancer & Oncology Source Type: research

Sodium Acetate and Sodium Butyrate Differentially Upregulate Antimicrobial Component Production in Mammary Glands of Lactating Goats
AbstractShort-chain fatty acids activate antimicrobial component production in the intestine. However, their effects on mammary glands remain unclear. We investigated the effects of acetate and butyrate on antimicrobial component production in mammary epithelial cells (MECs) or leukocytes cultured in vitro and in mammary glands of lactating Tokara goats in vivo. Our results showed that butyrate enhanced the production of β-defensin-1 and S100A7 in MECs. Additionally, the infusion of butyrate into mammary glands through the teats enhanced β-defensin-1 and S100A7 concentrations in milk. The infusion of acetate also increas...
Source: Journal of Mammary Gland Biology and Neoplasia - June 9, 2022 Category: Cancer & Oncology Source Type: research

Adverse Effects of High Temperature On Mammary Alveolar Development In Vitro
In this study, we investigated the effects of high temperature on this mammary alveolar development process using two types of culture models including embedded organoids of MECs in Matrigel; these models reproduced mammary alveolar bud induction and alveolar luminal formation. Results showed that a culture temperature of 41  °C repressed alveolar bud induction and inhibited alveolar luminal formation. In addition, the treatment at 41 °C decreased the number of proliferating mammary epithelial cells but did not affect cell migration. Levels of phosphorylated Akt, -ERK1/2, -HSP90, and -HSP27 were increased in organoi ds...
Source: Journal of Mammary Gland Biology and Neoplasia - May 17, 2022 Category: Cancer & Oncology Source Type: research

Ductal Carcinoma in Situ: Molecular Changes Accompanying Disease Progression
AbstractDuctal carcinoma in situ (DCIS) is a non-obligate precursor of invasive ductal carcinoma  (IDC), whereby if left untreated, approximately 12% of patients develop invasive disease. The current standard of care is surgical removal of the lesion, to prevent potential progression, and radiotherapy to reduce risk of recurrence. There is substantial overtreatment of DCIS patients, considerin g not all DCIS lesions progress to invasive disease. Hence, there is a critical imperative to better predict which DCIS lesions are destined for poor outcome and which are not, allowing for tailored treatment. Active surveillance is...
Source: Journal of Mammary Gland Biology and Neoplasia - May 14, 2022 Category: Cancer & Oncology Source Type: research

CCND1 Amplification in Breast Cancer -associations With Proliferation, Histopathological Grade, Molecular Subtype and Prognosis
In this study ofCCND1 in primary BCs and corresponding axillary lymph node metastases (LNM),we examine associations betweenCCND1 CN in primary BCs and proliferation status, molecular subtype, and prognosis. Furthermore, we studied associations betweenCCND1 CN and CNs ofFGFR1 andZNF703, both of which are located on 8p12.  Fluorescence in situ hybridization probes forCCND1 and chromosome 11 centromere were used on tissue microarrays comprising 526 BCs and 123 LNM. We assessed associations betweenCCND1 CN and tumour characteristics using Pearson ’s χ2 test, and estimated cumulative risks of death from BC and hazard rati...
Source: Journal of Mammary Gland Biology and Neoplasia - April 22, 2022 Category: Cancer & Oncology Source Type: research

Circ_0008500 Knockdown Improves Radiosensitivity and Inhibits Tumorigenesis in Breast Cancer Through the miR-758-3p/PFN2 Axis
In conclusion, circ_0008500 inhibition promoted the radiosensitivity and restrained the development of breast cancer by downregulating PFN2 expression via targeting miR-758-3p. (Source: Journal of Mammary Gland Biology and Neoplasia)
Source: Journal of Mammary Gland Biology and Neoplasia - March 3, 2022 Category: Cancer & Oncology Source Type: research