Along with PaO2/FiO2 ratio and lymphopenia, low HLA-DR monocytes are the only additional parameter that independently predicts the clinical course of undifferentiated SARS-CoV-2 patients in Emergency Departments
J Leukoc Biol. 2024 Feb 15:qiae022. doi: 10.1093/jleuko/qiae022. Online ahead of print.ABSTRACTSince 1/3 of patients deteriorate after their admission to the emergency department (ED), assessing the prognosis of COVID-19 patients is of great importance. But to date, only lymphopenia and PaO2/FiO2 (P/F) ratio have been reported as partly predictive of COVID-19 further deterioration and their association has not been evaluated. We asked whether other key biomarkers of SARS-CoV2 immunologic defects - increase in circulating immature granulocytes (IGs), loss of monocyte HLA-DR (mHLA-DR) expression and monocyte differentiation ...
Source: Journal of Leukocyte Biology - February 17, 2024 Category: Hematology Authors: Thomas Lafon Nicolas Chapuis Estelle Guerin Thomas Daix Marcela Otranto Ahmed Boumediene Robin Jeannet Michaela Fontenay Henri Hani Karam Philippe Vignon Guillaume Monneret Bruno Fran çois Jean-Philippe Jais Jean Feuillard Source Type: research
6-Formylindolo[3,2-b]carbazole, a potent ligand for the aryl hydrocarbon receptor, attenuates concanavalin-induced hepatitis by limiting T-cell activation and infiltration of proinflammatory CD11b+ Kupffer cells
In this study, we investigated the effect of aryl hydrocarbon receptor activation by FICZ in a murine model of autoimmune hepatitis induced by concanavalin A. High-throughput sequencing techniques such as single-cell RNA sequencing and assay for transposase accessible chromatin sequencing were used to explore the mechanisms through which FICZ induces its effects. FICZ treatment attenuated concanavalin A-induced hepatitis, evidenced by decreased T-cell infiltration, decreased circulating alanine transaminase levels, and suppression of proinflammatory cytokines. Concanavalin A revealed an increase in natural killer T cells, ...
Source: Journal of Leukocyte Biology - February 17, 2024 Category: Hematology Authors: Alkeiver S Cannon Bryan L Holloman Kiesha Wilson Kathryn Miranda Prakash S Nagarkatti Mitzi Nagarkatti Source Type: research
Along with PaO2/FiO2 ratio and lymphopenia, low HLA-DR monocytes are the only additional parameter that independently predicts the clinical course of undifferentiated SARS-CoV-2 patients in Emergency Departments
J Leukoc Biol. 2024 Feb 15:qiae022. doi: 10.1093/jleuko/qiae022. Online ahead of print.ABSTRACTSince 1/3 of patients deteriorate after their admission to the emergency department (ED), assessing the prognosis of COVID-19 patients is of great importance. But to date, only lymphopenia and PaO2/FiO2 (P/F) ratio have been reported as partly predictive of COVID-19 further deterioration and their association has not been evaluated. We asked whether other key biomarkers of SARS-CoV2 immunologic defects - increase in circulating immature granulocytes (IGs), loss of monocyte HLA-DR (mHLA-DR) expression and monocyte differentiation ...
Source: Journal of Leukocyte Biology - February 17, 2024 Category: Hematology Authors: Thomas Lafon Nicolas Chapuis Estelle Guerin Thomas Daix Marcela Otranto Ahmed Boumediene Robin Jeannet Michaela Fontenay Henri Hani Karam Philippe Vignon Guillaume Monneret Bruno Fran çois Jean-Philippe Jais Jean Feuillard Source Type: research
6-Formylindolo[3,2-b]carbazole, a potent ligand for the aryl hydrocarbon receptor, attenuates concanavalin-induced hepatitis by limiting T-cell activation and infiltration of proinflammatory CD11b+ Kupffer cells
In this study, we investigated the effect of aryl hydrocarbon receptor activation by FICZ in a murine model of autoimmune hepatitis induced by concanavalin A. High-throughput sequencing techniques such as single-cell RNA sequencing and assay for transposase accessible chromatin sequencing were used to explore the mechanisms through which FICZ induces its effects. FICZ treatment attenuated concanavalin A-induced hepatitis, evidenced by decreased T-cell infiltration, decreased circulating alanine transaminase levels, and suppression of proinflammatory cytokines. Concanavalin A revealed an increase in natural killer T cells, ...
Source: Journal of Leukocyte Biology - February 17, 2024 Category: Hematology Authors: Alkeiver S Cannon Bryan L Holloman Kiesha Wilson Kathryn Miranda Prakash S Nagarkatti Mitzi Nagarkatti Source Type: research
Pharmacological evidences that the inhibitory effects of prostaglandin E2 are mediated by the EP2 and EP4 receptors in human neutrophils
J Leukoc Biol. 2024 Feb 12:qiae029. doi: 10.1093/jleuko/qiae029. Online ahead of print.ABSTRACTProstaglandin (PG) E2 is a recognized inhibitor of granulocyte functions. However, most of the data supporting this was obtained when available pharmacological tools mainly targeted the EP2 receptor. Herein, we revisited the inhibitory effect of PGE2 on reactive oxygen species production, leukotriene biosynthesis and migration in human neutrophils. Our data confirm the inhibitory effect of PGE2 on these functions and unravel that the effect of PGE2 on human neutrophils is obtained by the combined action of EP2 and EP4 agonism. Ac...
Source: Journal of Leukocyte Biology - February 12, 2024 Category: Hematology Authors: Jean-Philippe C Lavoie M élissa Simard Hilal Kalkan Volatiana Rakotoarivelo Sandrine Huot Vincenzo Di Marzo Andr éanne Côté Marc Pouliot Nicolas Flamand Source Type: research
Pharmacological evidences that the inhibitory effects of prostaglandin E2 are mediated by the EP2 and EP4 receptors in human neutrophils
J Leukoc Biol. 2024 Feb 12:qiae029. doi: 10.1093/jleuko/qiae029. Online ahead of print.ABSTRACTProstaglandin (PG) E2 is a recognized inhibitor of granulocyte functions. However, most of the data supporting this was obtained when available pharmacological tools mainly targeted the EP2 receptor. Herein, we revisited the inhibitory effect of PGE2 on reactive oxygen species production, leukotriene biosynthesis and migration in human neutrophils. Our data confirm the inhibitory effect of PGE2 on these functions and unravel that the effect of PGE2 on human neutrophils is obtained by the combined action of EP2 and EP4 agonism. Ac...
Source: Journal of Leukocyte Biology - February 12, 2024 Category: Hematology Authors: Jean-Philippe C Lavoie M élissa Simard Hilal Kalkan Volatiana Rakotoarivelo Sandrine Huot Vincenzo Di Marzo Andr éanne Côté Marc Pouliot Nicolas Flamand Source Type: research
Pharmacological evidences that the inhibitory effects of prostaglandin E2 are mediated by the EP2 and EP4 receptors in human neutrophils
J Leukoc Biol. 2024 Feb 12:qiae029. doi: 10.1093/jleuko/qiae029. Online ahead of print.ABSTRACTProstaglandin (PG) E2 is a recognized inhibitor of granulocyte functions. However, most of the data supporting this was obtained when available pharmacological tools mainly targeted the EP2 receptor. Herein, we revisited the inhibitory effect of PGE2 on reactive oxygen species production, leukotriene biosynthesis and migration in human neutrophils. Our data confirm the inhibitory effect of PGE2 on these functions and unravel that the effect of PGE2 on human neutrophils is obtained by the combined action of EP2 and EP4 agonism. Ac...
Source: Journal of Leukocyte Biology - February 12, 2024 Category: Hematology Authors: Jean-Philippe C Lavoie M élissa Simard Hilal Kalkan Volatiana Rakotoarivelo Sandrine Huot Vincenzo Di Marzo Andr éanne Côté Marc Pouliot Nicolas Flamand Source Type: research
A Comprehensively Prognostic and Immunological Analysis of PARP11 in Pan-cancer
In this study we used multiple databases to assess PARP11 expression, which associations with clinical outcomes, immune checkpoint factors, prognostic significance, genomic characteristics, and immunological aspects. The analysis revealed varying expression levels of PARP11 across different cancer types and a significant correlation between its expression and immune cell infiltration. Insights from the CellMiner database suggest a strong link between PARP11 expression and sensitivity to anticancer drugs, highlighting its potential as a therapeutic target. Moreover, PARP11 expression correlates with patient survival during ...
Source: Journal of Leukocyte Biology - February 9, 2024 Category: Hematology Authors: Shengli Wang Mingyue Zhang Tao Li Xinru Chen Qinhan Wu Dan Tian Zvi Granot Hongbiao Xu Jianlei Hao Hongru Zhang Source Type: research
Exploring risk factors and molecular targets in leukemia patients with COVID-19: a bioinformatics analysis of differential gene expression
J Leukoc Biol. 2024 Feb 7:qiae002. doi: 10.1093/jleuko/qiae002. Online ahead of print.ABSTRACTThe molecular mechanism of COVID-19's pathogenic effects in leukemia patients is still poorly known. Our study investigated the possible disease mechanism of COVID-19 and its associated risk factors in patients with leukemia utilizing differential gene expression analysis. We also employed network-based approaches to identify molecular targets that could potentially diagnose and treat COVID-19-infected leukemia patients. Our study demonstrated a shared set of 60 genes that are expressed differentially among patients with leukemia ...
Source: Journal of Leukocyte Biology - February 7, 2024 Category: Hematology Authors: Md Asad Ullah Abu Tayab Moin Jannatul Ferdous Nipa Nafisa Nawal Islam Fatema Tuz Johora Rahee Hasan Chowdhury Saiful Islam Source Type: research
Tumor-infiltrating γδ T cells as targets of immune checkpoint blockade in melanoma
This study offers critical insights into the dynamic interaction between γδ T cells, immune checkpoint receptors, and melanoma, providing valuable prospectives for potential therapeutic avenues and predictive markers in this intricate interplay.PMID:38324004 | DOI:10.1093/jleuko/qiae023 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - February 7, 2024 Category: Hematology Authors: Marta Di Simone Anna Maria Corsale Francesca Toia Mojtaba Shekarkar Azgomi Anna Barbara Di Stefano Elena Lo Presti Adriana Cordova Luigi Montesano Francesco Dieli Serena Meraviglia Source Type: research
Tissue damage from chronic liver injury inhibits peripheral NK cell abundance and proinflammatory function
J Leukoc Biol. 2024 Feb 5:qiae027. doi: 10.1093/jleuko/qiae027. Online ahead of print.ABSTRACTOne of the difficulties in the treatment of hepatocellular carcinoma is that it is impossible to eliminate the inhibitory effect of tumor microenvironment on immune response. Therefore, it is particularly important to understand the formation process of tumor microenvironment. Chronic inflammation is the core factor of cancer occurrence and the leading stage of inflammation-cancer transformation, and the NK cell subsets play an important role in it. Our study confirmed that in the stage of chronic liver injury, the local immunosup...
Source: Journal of Leukocyte Biology - February 5, 2024 Category: Hematology Authors: Zonghao You Shaoxue Ling Shuwu Zhao Haixing Han Yuhong Bian Yongzhi He Xi Chen Source Type: research
Abnormal expression of CUX1 influences autophagy activation in paroxysmal nocturnal hemoglobinuria
J Leukoc Biol. 2024 Feb 5:qiae008. doi: 10.1093/jleuko/qiae008. Online ahead of print.ABSTRACTThe mechanism underlying autophagy in paroxysmal nocturnal hemoglobinuria (PNH) remains largely unknown. We previously sequenced the entire genome exon of the CD59- cells from 13 patients with PNH and found genes such as CUX1 encoding Cut-like homeobox 1. Peripheral blood samples from nine patients with PNH and seven healthy controls were obtained to measure CUX1 expression. The correlation between CUX1 mRNA expression and PNH clinical indicators was analyzed. To simulate CUX1 expression in patients with PNH, we generated a panel ...
Source: Journal of Leukocyte Biology - February 5, 2024 Category: Hematology Authors: Junshu Wu Liyan Li Zhaoyun Liu Honglei Wang Yingying Chen Lijie Zeng Guanrou Wang Hui Liu Rong Fu Source Type: research
Cxcl17 is a proinflammatory chemokine and promotes neutrophil trafficking
J Leukoc Biol. 2024 Jan 31:qiae028. doi: 10.1093/jleuko/qiae028. Online ahead of print.ABSTRACTCXCL17, a novel member of the CXC chemokine class, has been implicated in several human pathologies, but its role in mediating immune response is not well understood. Characteristic features of immune response include resident macrophages orchestrating successive and structured recruitment of neutrophils and monocytes to the insult site. Here, we show that Cxcl17 knockout (KO) mice, compared to the littermate wildtype (WT) control, were significantly impaired in peritoneal neutrophil recruitment post-lipopolysaccharide (LPS) chal...
Source: Journal of Leukocyte Biology - February 1, 2024 Category: Hematology Authors: Emily Lowry Rani C Chellappa Brigith Penaranda Kirti V Sawant Maki Wakamiya Roberto P Garofalo Krishna Rajarathnam Source Type: research
Epigenetic regulation of innate immune dynamics during inflammation
J Leukoc Biol. 2024 Feb 1:qiae026. doi: 10.1093/jleuko/qiae026. Online ahead of print.ABSTRACTInnate immune cells play essential roles in modulating both immune defense and inflammation by expressing a diverse array of cytokines and inflammatory mediators, phagocytizing pathogens to promote immune clearance, and assisting with the adaptive immune processes through antigen presentation. Rudimentary innate immune "memory" states such as training, tolerance, and exhaustion develop based on the nature, strength, and duration of immune challenge, thereby enabling dynamic transcriptional reprogramming to alter present and future...
Source: Journal of Leukocyte Biology - February 1, 2024 Category: Hematology Authors: Blake A Caldwell Liwu Li Source Type: research
Ally, adversary, or arbitrator? The context-dependent role of eosinophils in vaccination for respiratory viruses and subsequent breakthrough infections
J Leukoc Biol. 2024 Jan 30:qiae010. doi: 10.1093/jleuko/qiae010. Online ahead of print.ABSTRACTEosinophils are a critical type of immune cell and central players in Type 2 immunity. Existing literature suggests that eosinophils also can play a role in host antiviral responses, typically Type 1 immune events, against multiple respiratory viruses, both directly through release of antiviral mediators and indirectly through activation of other effector cell types. One way to prime host immune responses towards effective antiviral responses is through vaccination, where typically a Type 1-skewed immunity is desirable in the con...
Source: Journal of Leukocyte Biology - January 30, 2024 Category: Hematology Authors: Lauren A Chang Michael Schotsaert Source Type: research
