Tissue damage from chronic liver injury inhibits peripheral NK cell abundance and proinflammatory function

J Leukoc Biol. 2024 Feb 5:qiae027. doi: 10.1093/jleuko/qiae027. Online ahead of print.ABSTRACTOne of the difficulties in the treatment of hepatocellular carcinoma is that it is impossible to eliminate the inhibitory effect of tumor microenvironment on immune response. Therefore, it is particularly important to understand the formation process of tumor microenvironment. Chronic inflammation is the core factor of cancer occurrence and the leading stage of inflammation-cancer transformation, and the NK cell subsets play an important role in it. Our study confirmed that in the stage of chronic liver injury, the local immunosuppressive microenvironment of the liver, that is, the damaged microenvironment, has been formed, but this inhibitory effect is only for peripheral NK cells and has no effect on tissue resident NK subsets. The markers of damage microenvironment are the same as those of tumor microenvironment.PMID:38315633 | DOI:10.1093/jleuko/qiae027
Source: Journal of Leukocyte Biology - Category: Hematology Authors: Source Type: research